Microarray-based detection and expression analysis of new genes associated with drug resistance in ovarian cancer cell lines

Purpose The present study is to discover a new genes associated with drug resistance development in ovarian cancer. Methods We used microarray analysis to determine alterations in the level of expression of genes in cisplatin- (CisPt), doxorubicin- (Dox), topotecan- (Top), and paclitaxel- (Pac) resistant variants of W1 and A2780 ovarian cancer cell lines. Immunohistochemistry assay was used to determine protein expression in ovarian cancer patients. Results We observed alterations in the expression of 22 genes that were common to all three cell lines that were resistant to the same cytostatic drug. The level of expression of 13 genes was upregulated and that of nine genes was downregulated. In the CisPt-resistant cell line, we observed downregulated expression of ABCC6, BST2, ERAP2 and MCTP1; in the Pac-resistant cell line, we observe upregulated expression of ABCB1, EPHA7 and RUNDC3B and downregulated expression of LIPG, MCTP1, NSBP1, PCDH9, PTPRK and SEMA3A. The expression levels of three genes, ABCB1, ABCB4 and IFI16, were upregulated in the Dox-resistant cell lines. In the Top-resistant cell lines, we observed increased expression levels of ABCG2, HERC5, IFIH1, MYOT, S100A3, SAMD4A, SPP1 and TGFBI and decreased expression levels of MCTP1 and PTPRK. The expression of EPHA7, IFI16, SPP1 and TGFBI was confirmed at protein level in analyzed ovarian cancer patients.. Conclusions The expression profiles of the investigated cell lines indicated that new candidate genes are related to the development of resistance to the cytostatic drugs that are used in first- and second-line chemotherapy of ovarian cancer.

• Publication year

  2017

• Venue

  OncoTarget

• Publication date

  2017-05-29

• Fields of study

  Medicine

• Identifiers
  DOI 10.18632/oncotarget.18278PMID 28611294PMCID 5564819
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• DNA damage response--a double-edged sword in cancer prevention and cancer therapy.

  2015cited by this paper
• S100A3 suppression inhibits in vitro and in vivo tumor growth and invasion of human castration-resistant prostate cancer cells.

  2015cited by this paper
• Identification of HERC5 and its potential role in NSCLC progression

  2015cited by this paper
• POSTN/TGFBI-associated stromal signature predicts poor prognosis in serous epithelial ovarian cancer.

  2014cited by this paper
• Decreased expression of SEMA3A is associated with poor prognosis in gastric carcinoma.

  2014cited by this paper
• Protocadherin 9 inhibits epithelial-mesenchymal transition and cell migration through activating GSK-3β in hepatocellular carcinoma.

  2014cited by this paper
• Expression of MDR1 and MDR3 gene products in paclitaxel-, doxorubicin- and vincristine-resistant cell lines.

  2014cited by this paper
• Drug transporter expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line.

  2014cited by this paper
• Extracellular Matrix Proteins Expression Profiling in Chemoresistant Variants of the A2780 Ovarian Cancer Cell Line

  2014cited by this paper
• A Role for Naturally Occurring Alleles of Endoplasmic Reticulum Aminopeptidases in Tumor Immunity and Cancer Pre-Disposition

  2014cited by this paper
• Significance of semaphorin-3A and MMP-14 protein expression in non-small cell lung cancer

  2014cited by this paper
• Microarray-based detection and expression analysis of extracellular matrix proteins in drug‑resistant ovarian cancer cell lines.

  2014cited by this paper
• Smaug/SAMD4A Restores Translational Activity of CUGBP1 and Suppresses CUG-Induced Myopathy

  2013cited by this paper
• MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma

  2013cited by this paper
• Nonclassical Activation of Hedgehog Signaling Enhances Multidrug Resistance and Makes Cancer Cells Refractory to Smoothened-targeting Hedgehog Inhibition*

  2013cited by this paper
• Tumor Derived Mutations of Protein Tyrosine Phosphatase Receptor Type K Affect Its Function and Alter Sensitivity to Chemotherapeutics in Glioma

  2013cited by this paper
• Microarray-based detection and expression analysis of ABC and SLC transporters in drug-resistant ovarian cancer cell lines.

  2013cited by this paper
• Protein tyrosine phosphatase kappa (PTPRK) is a negative regulator of adhesion and invasion of breast cancer cells, and associates with poor prognosis of breast cancer

  2013cited by this paper
• Identification of Novel AR-Targeted MicroRNAs Mediating Androgen Signalling through Critical Pathways to Regulate Cell Viability in Prostate Cancer

  2013cited by this paper
• Antigenic peptide trimming by ER aminopeptidases--insights from structural studies.

  2013cited by this paper
• BST-2 is a potential activator of invasion and migration in tamoxifen-resistant breast cancer cells.

  2013cited by this paper
• Upregulation of Drug Transporter Expression by Osteopontin in Prostate Cancer Cells

  2013cited by this paper
• Role of S100A3 in human colorectal cancer and the anticancer effect of cantharidinate

  2013cited by this paper
• ß3 integrin modulates transforming growth factor beta induced (TGFBI) function and paclitaxel response in ovarian cancer cells

  2012cited by this paper
• Downregulation of PCDH9 predicts prognosis for patients with glioma.

  2012cited by this paper
• TGFBI promoter hypermethylation correlating with paclitaxel chemoresistance in ovarian cancer

  2012cited by this paper
• Transforming Growth Factor-Beta-Induced Protein (TGFBI)/(βig-H3): A Matrix Protein with Dual Functions in Ovarian Cancer

  2012cited by this paper
• MDR Gene Expression Analysis of Six Drug-Resistant Ovarian Cancer Cell Lines

  2012influential reference
• Functional validation of new pathways in lipoprotein metabolism identified by human genetics

  2011cited by this paper
• Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag

  2011cited by this paper
• Non-clustered protocadherin

  2011cited by this paper
• Frequent promoter hypermethylation of TGFBI in epithelial ovarian cancer.

  2010cited by this paper
• Secreted form of EphA7 in lung cancer.

  2010cited by this paper
• [Expression of EphA7 protein in primary hepatocellular carcinoma and its clinical significance].

  2010cited by this paper
• HMGN5/NSBP1: a new member of the HMGN protein family that affects chromatin structure and function.

  2010cited by this paper
• Osteopontin is involved in the formation of malignant pleural effusion in lung cancer.

  2009cited by this paper
• Up-regulation of bone marrow stromal protein 2 (BST2) in breast cancer with bone metastasis

  2009cited by this paper
• DNA Topoisomerases

  2009cited by this paper
• Aberrant methylation of EphA7 in human prostate cancer and its relation to clinicopathologic features

  2009cited by this paper
• Ovarian cancer

  2009cited by this paper
• A Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer

  2009cited by this paper
• Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

  2008cited by this paper
• [Effect of nucleosomal binding protein 1 in androgen-independent prostatic carcinoma].

  2008cited by this paper
• Role of IFI16 in DNA damage and checkpoint.

  2008cited by this paper
• The CRMP family of proteins and their role in Sema3A signaling.

  2007cited by this paper
• ABCG2: determining its relevance in clinical drug resistance

  2007cited by this paper
• Osteopontin in metastatic lesions as a prognostic marker in ovarian cancers.

  2007cited by this paper
• Randomized phase III trial of gemcitabine compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer.

  2007cited by this paper
• Mechanisms of resistance to cisplatin and carboplatin.

  2007cited by this paper
• Identification of genes with differential expression in chemoresistant epithelial ovarian cancer using high-density oligonucleotide microarrays.

  2006cited by this paper
• Genomewide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells.

  2006cited by this paper
• Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours

  2006cited by this paper
• Gene expression profile analysis of an isogenic tumour metastasis model reveals a functional role for oncogene AF1Q in breast cancer metastasis.

  2006cited by this paper
• Distinct gene expression patterns in a tamoxifen-sensitive human mammary carcinoma xenograft and its tamoxifen-resistant subline MaCa 3366/TAM.

  2005cited by this paper
• Augmented expression of metallothionein and glutathione S-transferase pi as unfavourable prognostic factors in cisplatin-treated ovarian cancer patients

  2005influential reference
• Microtubule targeting agents: basic mechanisms of multidrug resistance (MDR).

  2005influential reference
• Downregulation of EphA7 by hypermethylation in colorectal cancer

  2005cited by this paper
• Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy

  2005cited by this paper
• Expression of RPIP9 (Rap2 interacting protein 9) is activated in breast carcinoma and correlates with a poor prognosis

  2005cited by this paper
• Evolutionarily Conserved Multiple C2 Domain Proteins with Two Transmembrane Regions (MCTPs) and Unusual Ca2+ Binding Properties*

  2005cited by this paper
• ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal

  2005cited by this paper
• Requirement of IFI16 for the Maximal Activation of p53 Induced by Ionizing Radiation*

  2004cited by this paper
• Long-term survival advantage for women treated with pegylated liposomal doxorubicin compared with topotecan in a phase 3 randomized study of recurrent and refractory epithelial ovarian cancer.

  2004cited by this paper
• Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence

  2003cited by this paper
• Paclitaxel plus platinum-based chemotherapy versus conventional platinum-based chemotherapy in women with relapsed ovarian cancer: the ICON4/AGO-OVAR-2.2 trial.

  2003cited by this paper
• Blaustein’s Pathology of the Female Genital Tract

  2003cited by this paper
• The role of ABC transporters in clinical practice.

  2003cited by this paper
• Mechanisms of cancer drug resistance.

  2002influential reference
• Osteopontin as a potential diagnostic biomarker for ovarian cancer.

  2002cited by this paper
• Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6).

  2002cited by this paper
• Multidrug resistance in cancer: role of ATP–dependent transporters

  2002cited by this paper
• Mechanisms of resistance to cisplatin.

  2001influential reference
• Protein tyrosine phosphatase genes downregulated in melanoma.

  2001cited by this paper
• Cancer statistics, 2000

  2000cited by this paper
• A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins.

  1999cited by this paper
• Rapid activation of MDR1 gene expression in human metastatic sarcoma after in vivo exposure to doxorubicin.

  1999cited by this paper
• Overexpression of class I, II or IVb beta-tubulin isotypes in CHO cells is insufficient to confer resistance to paclitaxel.

  1999cited by this paper
• Myotilin, a novel sarcomeric protein with two Ig-like domains, is encoded by a candidate gene for limb-girdle muscular dystrophy.

  1999cited by this paper
• Cytogenetical assignment and physical mapping of the human R-PTP-kappa gene (PTPRK) to the putative tumor suppressor gene region 6q22.2-q22.3.

  1998cited by this paper
• The EnVision++ system: a new immunohistochemical method for diagnostics and research. Critical comparison with the APAAP, ChemMate, CSA, LABC, and SABC techniques.

  1998cited by this paper
• The Eph family receptors and ligands.

  1998cited by this paper
• Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle

  1998cited by this paper
• Paclitaxel-resistant Human Ovarian Cancer Cells Have Mutant β-Tubulins That Exhibit Impaired Paclitaxel-driven Polymerization*

  1997cited by this paper
• The S100 family of EF-hand calcium-binding proteins: functions and pathology.

  1996cited by this paper
• Cellular resistance to topoisomerase poisons.

  1996cited by this paper
• A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.

  1996influential reference
• DNA topoisomerases.

  1996cited by this paper
• Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth.

  1995cited by this paper
• Molecular genetics for the clinician

  1993cited by this paper
• Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance.

  1993influential reference
• In vitro prediction of cytostatic drug resistance in primary cell cultures of solid malignant tumours.

  1993cited by this paper
• cDNA cloning, mRNA distribution and heterogeneity, chromosomal location, and RFLP analysis of human osteopontin (OPN).

  1990cited by this paper
• Cancer statistics

  1989cited by this paper
• DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe.

  1987cited by this paper
• Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA

  1987cited by this paper

• JAK/STAT1-interferon-ISGylation networks in breast cancer resistance to inhibitors of FOXM1 and CDK4/6.

  2026cites this paper
• SAMD4B: a novel prognostic biomarker of endometrial carcinoma

  2025cites this paper
• A calcium-sensing MCTP1/FYN/MEF2C circuit drives therapy-induced neuroendocrine prostate cancer

  2025cites this paper
• Exploratory Gene Expression Profiling of Cisplatin-Induced Neurotoxicity in Rat Brain

  2025cites this paper
• Oncogenic Role of SAMD4B in Breast Cancer Progression by Activating Wnt/β-Catenin Pathway

  2025cites this paper
• The dual role of PCDH9 in tumors, neurological and developmental diseases

  2025cites this paper
• Genome‐Wide CRISPR‐Cas9 Knockout Screening Identifies Genes Modulating Cisplatin‐Induced Cytotoxicity in Renal Proximal Tubule Epithelial Cells

  2025cites this paper
• Doxorubicin and topotecan resistance in ovarian cancer: Gene expression and microenvironment analysis in 2D and 3D models.

  2025cites this paper
• Advances in S100 protein family for gynecological malignancies

  2025cites this paper
• Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review)

  2024cites this paper
• Colocalization of cancer-associated biomarkers on single extracellular vesicles for early detection of cancer.

  2024cites this paper
• Sorcin in Cancer Development and Chemotherapeutic Drug Resistance

  2024cites this paper
• Therapy-induced secretion of spliceosomal components mediates pro-survival crosstalk between ovarian cancer cells

  2024cites this paper
• MCTP1 increases the malignancy of androgen-deprived prostate cancer cells by inducing neuroendocrine differentiation and EMT

  2024cites this paper
• Interferon-Gamma-Inducible Protein 16 Inhibits Hepatocellular Carcinoma via Interferon Regulatory Factor 3 on Chemosensitivity

  2024cites this paper
• RNA binding protein SAMD4: current knowledge and future perspectives

  2023influential citation
• The high-grade serous ovarian cancer metastasis and chemoresistance in 3D models.

  2023cites this paper
• A Regulator Role for the ATP-Binding Cassette Subfamily C Member 6 Transporter in HepG2 Cells: Effect on the Dynamics of Cell–Cell and Cell–Matrix Interactions

  2023cites this paper
• The TGFBI gene and protein expression in topotecan resistant ovarian cancer cell lines.

  2023cites this paper
• Renal pharmacokinetic adaptation to cholestasis causes increased nephrotoxic drug accumulation by Mrp6 downregulation in mice.

  2023cites this paper
• Doxorubicin and other anthracyclines in cancers: Activity, chemoresistance and its overcoming.

  2023cites this paper
• The response and resistance to drugs in ovarian cancer cell lines in 2D monolayers and 3D spheroids.

  2023cites this paper
• The characterization of the sensitive ovarian cancer cell lines A2780 and W1 in response to ovarian CAFs.

  2023cites this paper
• Transcriptome analysis of newly established carboplatin-resistant ovarian cancer cell model reveals genes shared by drug resistance and drug-induced EMT

  2023cites this paper
• Clinical significance of circulating tumor cells and cell‐free DNA in pediatric rhabdomyosarcoma

  2022cites this paper
• Gene Expression Profiling Elucidates Cellular Responses to NCX4040 in Human Ovarian Tumor Cells: Implications in the Mechanisms of Action of NCX4040

  2022cites this paper
• cAMP-Dependent Signaling and Ovarian Cancer

  2022cites this paper
• Construction of miRNA‐lncRNA‐mRNA co‐expression network affecting EMT‐mediated cisplatin resistance in ovarian cancer

  2022cites this paper
• Screening of Specific and Common Pathways in Breast Cancer Cell Lines MCF-7 and MDA-MB-231 Treated with Chlorophyllides Composites

  2022cites this paper
• Prediction of Adrenocortical Carcinoma Relapse and Prognosis with a Set of Novel Multigene Panels

  2022cites this paper
• HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration.

  2022cites this paper
• The Profile of MicroRNA Expression and Potential Role in the Regulation of Drug-Resistant Genes in Doxorubicin and Topotecan Resistant Ovarian Cancer Cell Lines

  2022cites this paper
• Investigation of role of CpG methylation in some epithelial mesenchymal transition gene in a chemoresistant ovarian cancer cell line

  2022cites this paper
• The significance of interferon gamma inducible protein 16 (IFI16) expression in drug resistant ovarian cancer cell lines.

  2022cites this paper
• The Profile of MicroRNA Expression and Potential Role in the Regulation of Drug-Resistant Genes in Cisplatin- and Paclitaxel-Resistant Ovarian Cancer Cell Lines

  2022cites this paper
• High expression of RIPK2 is associated with Taxol resistance in serous ovarian cancer

  2021cites this paper
• Taxanes in cancer treatment: Activity, chemoresistance and its overcoming.

  2021cites this paper
• Effective Prediction of Prostate Cancer Recurrence through the IQGAP1 Network

  2021influential citation
• Morphological and molecular characteristics of spheroid formation in HT-29 and Caco-2 colorectal cancer cell lines

  2021cites this paper
• The DNA methylation-regulated MCTP1 activates the drug-resistance of esophageal cancer cells

  2021cites this paper
• The Dual Role of STAT1 in Ovarian Cancer: Insight Into Molecular Mechanisms and Application Potentials

  2021cites this paper
• Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs

  2021cites this paper
• Drug resistance evaluation in novel 3D in vitro model.

  2021cites this paper
• The role of the extracellular matrix protein TGFBI in cancer.

  2021cites this paper
• Comprehending the Proteomic Landscape of Ovarian Cancer: A Road to the Discovery of Disease Biomarkers

  2021cites this paper
• Crystal structure of clinically reported mutations Gly656Arg, Gly656Glu and Asp751His identified in the kinase domain of EphA7.

  2021cites this paper
• Investigation of the Role of CpG Methylation in Epithelial Mesenchymal Transition Master Genes in a Chemoresistant Ovarian Cancer Cell line

  2021cites this paper
• Activation of the ABCB1 Amplicon in Docetaxel- and Cabazitaxel-Resistant Prostate Cancer Cells

  2021cites this paper
• Microarrays and NGS for Drug Discovery

  2021cites this paper
• Drug resistance in gynecologic cancers: Findings and underlying mechanisms

  2021cites this paper
• Integrated Transcriptomic Analysis Revealed Hub Genes and Pathways Involved in Sorafenib Resistance in Hepatocellular Carcinoma

  2021cites this paper
• Integrated analysis of gene expression and DNA methylation profiles in ovarian cancer

  2020cites this paper
• Prediction of chemotherapeutic resistance in serous ovarian cancer with low-density custom microarray

  2020cites this paper
• Gene Expression Signatures of a Preclinical Mouse Model during Colorectal Cancer Progression under Low-Dose Metronomic Chemotherapy

  2020cites this paper
• From membrane to mineralization: the curious case of the ABCC6 transporter

  2020cites this paper
• Elucidation of Mechanisms of Topotecan-Induced Cell Death in Human Breast MCF-7 Cancer Cells by Gene Expression Analysis

  2020cites this paper
• HERC Ubiquitin Ligases in Cancer

  2020cites this paper
• Roles of S100 family members in drug resistance in tumors: Status and prospects.

  2020cites this paper
• The Significance of MicroRNAs Expression in Regulation of Extracellular Matrix and Other Drug Resistant Genes in Drug Resistant Ovarian Cancer Cell Lines

  2020cites this paper
• Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target

  2020cites this paper
• In vitro evolution and whole genome analysis to study chemotherapy drug resistance in haploid human cells

  2020cites this paper
• The involvement of MCTP1 in the drug-resistance of esophageal cancer cells

  2020cites this paper
• Commonly integrated epigenetic modifications of differentially expressed genes lead to adaptive resistance in cancer

  2019cites this paper
• The significance of microRNA genes expression in ovarian cancer cell lines resistant to cytotoxic drugs

  2019cites this paper
• The Impact of Integrin-Mediated Matrix Adhesion on Cisplatin Resistance of W1 Ovarian Cancer Cells

  2019cites this paper
• Identification of modules and hub genes associated with platinum-based chemotherapy resistance and treatment response in ovarian cancer by weighted gene co-expression network analysis

  2019cites this paper
• A multi-omics approach to uncover estrogen receptor (ER) and activator protein 1 (AP-1) signaling networks in breast cancer

  2019cites this paper
• Genome-wide bioinformatics analysis reveals CTCFL is upregulated in high-grade epithelial ovarian cancer

  2019cites this paper
• Identification of a Five-CpG Signature with Diagnostic Value in Thyroid Cancer

  2019cites this paper
• PTPRK Expression Is Downregulated in Drug Resistant Ovarian Cancer Cell Lines, and Especially in ALDH1A1 Positive CSCs-Like Populations

  2019influential citation
• Association of ABC gene profiles with time to progression and resistance in ovarian cancer revealed by bioinformatics analyses

  2019cites this paper
• Distinct prognostic roles of S100 mRNA expression in gastric cancer.

  2019cites this paper
• Drug resistance in topoisomerase-targeting therapy

  2018cites this paper
• Genomic amplification of chromosome 7 in the Doxorubicin resistant K562 cell line

  2018cites this paper
• ENTERING THE ERA OF MOLECULAR MEDICINE: ARE WE PREPARED?

  2018cites this paper
• New and Old Genes Associated with Primary and Established Responses to Paclitaxel Treatment in Ovarian Cancer Cell Lines

  2018influential citation
• Liposomal Combination Drug and siRNA Delivery to Combat Drug-Resistant Ovarian Cancer

  2018cites this paper
• Mutual Expression of ALDH1A1, LOX, and Collagens in Ovarian Cancer Cell Lines as Combined CSCs- and ECM-Related Models of Drug Resistance Development

  2018cites this paper
• Molecular bases of Sorcin-dependent resistance to chemotherapeutic agents

  2018cites this paper
• Myotilin, a New Topotecan Resistant Protein in Ovarian Cancer Cell Lines

  2018cites this paper
• Addressing Drug Resistance in Cancer with Macromolecular Chemotherapeutic Agents.

  2018cites this paper
• Microarray‐based identification of genes associated with prognosis and drug resistance in ovarian cancer

  2018cites this paper
• Loss of ABCB4 attenuates the caspase-dependent apoptosis regulating resistance to 5-Fu in colorectal cancer

  2018cites this paper
• The Role of Matrix Gla Protein (MGP) Expression in Paclitaxel and Topotecan Resistant Ovarian Cancer Cell Lines

  2018cites this paper
• Overexpression of kinesin family member 20A is associated with unfavorable clinical outcome and tumor progression in epithelial ovarian cancer

  2018cites this paper
• Circular RNA CpG island hypermethylation-associated silencing in human cancer

  2018cites this paper
• New and Old Genes Associated with Primary and Established Responses to Cisplatin and Topotecan Treatment in Ovarian Cancer Cell Lines

  2017cites this paper
• Not only P-glycoprotein: Amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins.

  2017influential citation