Humanized-BLT mouse model of Kaposi’s sarcoma-associated herpesvirus infection

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2014-02-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1318175111PMID 24516154PMCID PMC3939909
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Human immune responses and potential for vaccine assessment in humanized mice.

  2013cited by this paper
• New generation humanized mice for virus research: comparative aspects and future prospects.

  2013cited by this paper
• Humanized mice for immune system investigation: progress, promise and challenges

  2012cited by this paper
• Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A.

  2012cited by this paper
• Enhanced humoral and HLA‐A2‐restricted dengue virus‐specific T‐cell responses in humanized BLT NSG mice

  2012cited by this paper
• SIV infection induces accumulation of plasmacytoid dendritic cells in the gut mucosa.

  2012cited by this paper
• Multiple Defects, Including Premature Apoptosis, Prevent Kaposi's Sarcoma-Associated Herpesvirus Replication in Murine Cells

  2011cited by this paper
• Pathology of Kaposi’s Sarcoma-Associated Herpesvirus Infection

  2011cited by this paper
• Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV‐1 envelope proteins are largely mediated via human CD5+ B cells

  2011cited by this paper
• Humanized mouse models to study human diseases

  2010cited by this paper
• Bioluminescent Imaging Demonstrates That Transplanted Human Embryonic Stem Cell‐Derived CD34+ Cells Preferentially Develop into Endothelial Cells

  2009cited by this paper
• Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice

  2009cited by this paper
• Non-Human Primate Model of Kaposi's Sarcoma-Associated Herpesvirus Infection

  2009cited by this paper
• PECAM-1: a multi-functional molecule in inflammation and vascular biology.

  2007cited by this paper
• KSHV/HHV-8 infection of human hematopoietic progenitor (CD34+) cells: persistence of infection during hematopoiesis in vitro and in vivo.

  2006cited by this paper
• KSHV targets multiple leukocyte lineages during long-term productive infection in NOD/SCID mice.

  2006cited by this paper
• Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells

  2005cited by this paper
• Experimental transmission of Kaposi's sarcoma‐associated herpesvirus (KSHV/HHV‐8) to SIV‐positive and SIV‐negative rhesus macaques

  2004cited by this paper
• Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expression.

  2004cited by this paper
• Injection of human herpesvirus-8 in human skin engrafted on SCID mice induces Kaposi's sarcoma-like lesions.

  2001cited by this paper
• Primary human herpesvirus 8 infection generates a broadly specific CD8(+) T-cell response to viral lytic cycle proteins.

  2001cited by this paper
• Isolation of mouse spleen dendritic cells.

  2001cited by this paper
• Vertical transmission of Kaposi's sarcoma‐associated herpesvirus

  2001cited by this paper
• Kaposi's sarcoma.

  2000cited by this paper
• Experimental Transmission of Kaposi's Sarcoma–Associated Herpesvirus (Kshv/Hhv-8) to Scid-Hu Thy/Liv Mice

  1999cited by this paper
• Construction of Human‐SCID Chimeric Mice

  1998cited by this paper
• The KSHV/HHV8-infected BCBL-1 lymphoma line causes tumors in SCID mice but fails to transmit virus to a human peripheral blood mononuclear cell graft.

  1997cited by this paper
• The relationship between tumor necrosis factor and human immunodeficiency virus gene expression in lymphoid tissue

  1997cited by this paper
• Kaposi's sarcoma.

  1991cited by this paper

• Apolipoprotein E selectively supports gammaherpesvirus replication in macrophages

  2025cites this paper
• Humanized Mouse Systems to Study Viral Infection: A New Era in Immunology Research.

  2025cites this paper
• Animal models of human herpesvirus infection

  2025cites this paper
• Oncogenic Mechanisms of Kaposi's Sarcoma‐Associated Herpesvirus on Cell Metabolism and Cell Transformation

  2025cites this paper
• Gammaherpesvirus infection unveils exaggerated germinal center responses in an SR-BI-deficient host

  2025cites this paper
• Kaposi sarcoma-associated herpesvirus complement control protein (KCP) and glycoprotein K8.1 are not required for viral infection in vitro or in vivo

  2024cites this paper
• The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice.

  2024cites this paper
• High-fat diet feeding exacerbates HIV-1 rectal transmission

  2024cites this paper
• Guinea pig herpes like virus is a gamma herpesvirus

  2024cites this paper
• Mouse models of Kaposi sarcoma-associated herpesvirus (KSHV).

  2024cites this paper
• Characterization of double humanized BLT-mice with stable engraftment of a human gut bacterial microbiome

  2024cites this paper
• Challenges and innovations in hematopoietic stem cell transplantation: exploring bone marrow niches and new model systems

  2024cites this paper
• KSHV infection of B cells primes protective T cell responses in humanized mice

  2024cites this paper
• Mouse Models for Human Herpesviruses

  2023cites this paper
• Simian immunodeficiency virus-infected rhesus macaques with AIDS co-develop cardiovascular pathology and encephalitis

  2023cites this paper
• Co-infection and co-localization of Kaposi sarcoma-associated herpesvirus and Epstein-Barr virus in HIV-associated Kaposi sarcoma: a case report

  2023cites this paper
• A germ-free humanized mouse model shows the contribution of resident microbiota to human-specific pathogen infection

  2023cites this paper
• Upregulation of Cell Surface Glycoproteins in Correlation with KSHV LANA in the Kaposi Sarcoma Tumor Microenvironment

  2023cites this paper
• Spatially Resolved and Highly Multiplexed Protein and RNA In Situ Detection by Combining CODEX With RNAscope In Situ Hybridization

  2022cites this paper
• VIRIAL INFECTIONS: REPLICATION AND PATHOGENESIS MECHANISMS TO THERAPY Murine Models of Chronic Viral Infections and Associated Cancers

  2022cites this paper
• The Antagonism between the Murine Gammaherpesvirus Protein Kinase and Global Interferon Regulatory Factor 1 Expression Shapes the Establishment of Chronic Infection

  2022cites this paper
• T Cell-Specific STAT1 Expression Promotes Lytic Replication and Supports the Establishment of Gammaherpesvirus Latent Reservoir in Splenic B Cells

  2022cites this paper
• Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection

  2022cites this paper
• Whole-genome sequencing of Kaposi sarcoma-associated herpesvirus (KSHV/HHV8) reveals evidence for two African lineages.

  2022cites this paper
• Low-Density Lipoprotein Receptor Suppresses the Endogenous Cholesterol Synthesis Pathway To Oppose Gammaherpesvirus Replication in Primary Macrophages

  2021cites this paper
• Establishment of Tree Shrew Animal Model for Kaposi’s Sarcoma-Associated Herpesvirus (HHV-8) Infection

  2021cites this paper
• Conserved Gammaherpesvirus Protein Kinase Counters the Antiviral Effects of Myeloid Cell-Specific STAT1 Expression To Promote the Establishment of Splenic B Cell Latency

  2021cites this paper
• Humanized Mice for Infectious and Neurodegenerative disorders

  2021cites this paper
• Gammaherpesviruses and B Cells: A Relationship That Lasts a Lifetime

  2020cites this paper
• Probing Reconstituted Human Immune Systems in Mice With Oncogenic γ-Herpesvirus Infections

  2020cites this paper
• Modeling oncogenic herpesvirus infections in humanized mice.

  2020cites this paper
• Alterations in the gut microbiome by HIV-1 infection or a high-fat diet associates with systemic immune activation and inflammation in double humanized-BLT mice

  2020cites this paper
• Development of humanized mouse and rat models with full-thickness human skin and autologous immune cells

  2020cites this paper
• Animal Models for Gammaherpesvirus Infections: Recent Development in the Analysis of Virus-Induced Pathogenesis

  2020cites this paper
• Human Macrophages and Innate Lymphoid Cells: Tissue-resident Innate Immunity in Humanized Mice.

  2020cites this paper
• Towards Better Understanding of KSHV Life Cycle: from Transcription and Posttranscriptional Regulations to Pathogenesis

  2019cites this paper
• Nanoencapsulation introduces long-acting phenomenon to tenofovir alafenamide and emtricitabine drug combination: A comparative pre-exposure prophylaxis efficacy study against HIV-1 vaginal transmission.

  2019cites this paper
• Rhesus Macaque Rhadinovirus Encodes a Viral Interferon Regulatory Factor To Disrupt Promyelocytic Leukemia Nuclear Bodies and Antagonize Type I Interferon Signaling

  2019cites this paper
• LXR Alpha Restricts Gammaherpesvirus Reactivation from Latently Infected Peritoneal Cells

  2019cites this paper
• Immunodeficiencies that predispose to pathologies by human oncogenic γ-herpesviruses

  2019cites this paper
• Infection and immune control of human oncogenic γ-herpesviruses in humanized mice

  2019cites this paper
• A multivalent Kaposi sarcoma-associated herpesvirus-like particle vaccine capable of eliciting high titers of neutralizing antibodies in immunized rabbits.

  2019cites this paper
• Precision mouse models with expanded tropism for human pathogens

  2019cites this paper
• A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System.

  2019cites this paper
• Stable Engraftment of a Human Gut Bacterial Microbiome in Double Humanized BLT-mice

  2019cites this paper
• Mouse Models in Hematopoietic Stem Cell Gene Therapy and Genome Editing.

  2019cites this paper
• The Role of Dendritic Cells in Immune Control and Vaccination against γ-Herpesviruses

  2019cites this paper
• HUMANIZED MICE: CREATION, MODELS AND USE IN EXPERIMENTAL ONCOLOGY (REVIEW)

  2019cites this paper
• Investigation of LANA: a human virus tumor gene

  2019cites this paper
• Macrophages but not Astrocytes Harbor HIV DNA in the Brains of HIV-1-Infected Aviremic Individuals on Suppressive Antiretroviral Therapy

  2018influential citation
• Humanized mice: A brief overview on their diverse applications in biomedical research

  2018cites this paper
• A Hitchhiker's guide to humanized mice: new pathways to studying viral infections

  2018cites this paper
• [EBV/KSHV co-infection: an effective partnership].

  2018cites this paper
• Human γ-Herpesvirus Infection, Tumorigenesis, and Immune Control in Mice with Reconstituted Human Immune System Components

  2018cites this paper
• Brain is a potential sanctuary for subtype C HIV-1 irrespective of ART treatment outcome

  2018cites this paper
• Experimental co-transmission of Simian Immunodeficiency Virus (SIV) and the macaque homologs of the Kaposi Sarcoma-Associated Herpesvirus (KSHV) and Epstein-Barr Virus (EBV)

  2018cites this paper
• Human immunodeficiency virus infection induces lymphoid fibrosis in the BM-liver-thymus-spleen humanized mouse model.

  2018cites this paper
• Rhesus macaque rhadinovirus R12 is required for promyelocytic leukemia nuclear body disruption and inhibits innate immune responses

  2018cites this paper
• Animal Models of Human Gammaherpesvirus Infections.

  2018cites this paper
• Long‐acting parenteral combination antiretroviral loaded nano‐drug delivery system to treat chronic HIV‐1 infection: A humanized mouse model study

  2018cites this paper
• Humanized Mice as Unique Tools for Human-Specific Studies

  2018cites this paper
• KSHV microRNAs: Tricks of the Devil.

  2017cites this paper
• Persistent KSHV Infection Increases EBV-Associated Tumor Formation In Vivo via Enhanced EBV Lytic Gene Expression.

  2017cites this paper
• Double the Trouble When Herpesviruses Join Hands.

  2017cites this paper
• Tenofovir alafenamide and elvitegravir loaded nanoparticles for long-acting prevention of HIV-1 vaginal transmission

  2017cites this paper
• Humanized Mouse Models of Clinical Disease.

  2017cites this paper
• Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA

  2017cites this paper
• Seroanalysis of Felis catus gammaherpesvirus 1 infection in domestic cats

  2017cites this paper
• BALB/c mice immunized with a combination of virus-like particles incorporating Kaposi sarcoma-associated herpesvirus (KSHV) envelope glycoproteins gpK8.1, gB, and gH/gL induced comparable serum neutralizing antibody activity to UV-inactivated KSHV

  2017cites this paper
• Human Cytomegalovirus Induces Cellular and Humoral Virus-specific Immune Responses in Humanized BLT Mice

  2017cites this paper
• KSHV-Mediated Angiogenesis in Tumor Progression

  2016cites this paper
• Kaposi Sarcoma Associated Herpesvirus and Heme Oxygenase-1: the Bidirectional Relationship Between Virus and Host

  2016cites this paper
• Recapitulating Cross-Species Transmission of Simian Immunodeficiency Virus SIVcpz to Humans by Using Humanized BLT Mice

  2016cites this paper
• Tenofovir Disoproxil Fumarate Nanoparticles Prevent HIV-1 Vaginal Transmission in a Humanized Mouse Model

  2016cites this paper
• VRC01 antibody protects against vaginal and rectal transmission of human immunodeficiency virus 1 in hu-BLT mice

  2016cites this paper
• Recapitulating Cross-Species Transmission of SIVcpz to Humans Using Humanized-BLT Mice 1 2 3

  2016cites this paper
• Kaposi sarcoma-associated herpesvirus: immunobiology, oncogenesis, and therapy.

  2016cites this paper
• Topical Tenofovir Disoproxil Fumarate Nanoparticles Prevent HIV-1 Vaginal Transmission in a Humanized Mouse Model

  2016cites this paper
• Microenvironmental abnormalities induced by viral cooperation: Impact on lymphomagenesis.

  2015cites this paper
• Animal models of tumorigenic herpesviruses--an update.

  2015cites this paper
• Recent advances in the study of Kaposi’s sarcoma-associated herpesvirus replication and pathogenesis

  2015cites this paper
• Early Initiation of Antiretroviral Therapy Can Functionally Control Productive HIV-1 Infection in Humanized-BLT Mice

  2015cites this paper
• Site-Specific Differences in T Cell Frequencies and Phenotypes in the Blood and Gut of HIV-Uninfected and ART-Treated HIV+ Adults

  2015cites this paper
• SIV Infection of Lung Macrophages

  2015cites this paper
• Rhadinovirus Host Entry by Co-operative Infection

  2015influential citation
• Systemic Expression of Kaposi Sarcoma Herpesvirus (KSHV) Vflip in Endothelial Cells Leads to a Profound Proinflammatory Phenotype and Myeloid Lineage Remodeling In Vivo

  2015cites this paper
• Viral microRNA genomics and target validation.

  2014cites this paper
• Kaposi's Sarcoma-Associated Herpesvirus K3 and K5 Ubiquitin E3 Ligases Have Stage-Specific Immune Evasion Roles during Lytic Replication

  2014cites this paper
• Characterisation of the interactions between the KSHV ORF57 protein and the human TREX complex

  2014cites this paper
• Dendritic cells: key players in human herpesvirus 8 infection and pathogenesis

  2014cites this paper
• Oncogenes and RNA splicing of human tumor viruses

  2014cites this paper
• Epidemiology and Transmission of Kaposi’s Sarcoma-Associated Herpesvirus

  2014cites this paper
• Modelling of human herpesvirus infections in humanized mice.

  2014cites this paper
• Viral infections in mice with reconstituted human immune system components.

  2014cites this paper
• Human tumour viruses

  year unknowncites this paper