Topical treatment of psoriatic skin with methotrexate cream: a clinical, pharmacokinetic, and histological study.

Five patients were treated with either 0.25% methotrexate cream or placebo in a double blind trial. The evaluation showed no clinical or histological effect although the drug was absorbed from the skin. Methotrexate (MTX) accumulated in locally treated psoriasis plaques as well as in untreated plaques. The psoriatic skin concentrations were increased by a factor of 119 and 4, respectively. This observation is discussed in relation to the possible role of action of methotrexate in psoriasis. We suggest that methotrexate inhibits the chemotaxis of neutrophil leukocytes systemically and not primarily in the skin, thereby preventing development of the early stages in the psoriatic lesions.

• Publication year

  1986

• Venue

  Acta Dermato-Venereologica

• Publication date

  1986-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.2340/0001555566515519PMID 2433872
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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