HETEROLOGOUS CARRIERS IN THE ANAMNESTIC ANTIHAPTEN RESPONSE

Anamnestic antihapten responses were obtained to trinitrophenyl (TNP) when rabbits sensitized to trinitrophenyl-hemocyanin (TNP-KLH) were challenged with TNP-heterologous protein conjugates. Hapten-heterologous carrier conjugates elicited antihapten titers similar in magnitude to those elicited by the homologous carrier conjugate. Hapten-heterologous carrier recall of antihapten was successful as early as 37 days and as late as 11 months after sensitization. There was no correlation between anti-TNP-precipitating antibody titer after sensitization and the ability to respond to challenge by hapten-heterologous carrier. The results are discussed in terms of immunogenicity of sensitization, suppressive effects of persisting postsensitization antibody, and submolecular haptenic environment as factors possibly affecting the heterologous recall process.

• Publication year

  1968

• Venue

  Journal of Experimental Medicine

• Publication date

  1968-03-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.127.4.717PMID 4171054PMCID 2138479
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• STUDIES ON THE CONTROL OF ANTIBODY SYNTHESIS

  1967cited by this paper
• Developmental aspects of immunity.

  1967cited by this paper
• Immunochemical studies on delayed and arthus-type hypersensitivity reactions. I. The relationship between antigenic determinant size and antibody combining site size.

  1967cited by this paper
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  1967cited by this paper
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  1966cited by this paper
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  1966cited by this paper
• Symposium on in vitro studies of the immune response. I. Variations in the immune response to a simple determinant

  1966cited by this paper
• Immunogenicity of trinitrophenyl-hemocyanin: production of primary and secondary anti-hapten precipitins.

  1966influential reference
• THE SPECIFICITY OF ALLERGIC REACTIONS VII. IMMUNOLOGIC UNRESPONSIVENESS, DELAYED HYPERSENSITIVITY, AND CIRCULATING ANTIBODY TO PROTEINS AND HAPTEN-PROTEIN CONJUGATES IN ADULT GUINEA PIGS

  1964cited by this paper
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  1964cited by this paper
• IMMUNOCHEMICAL STUDY OF ANTIGENIC SPECIFICITY IN DELAYED HYPERSENSITIVITY

  1963cited by this paper
• Antibody Quality after Sequential Immunization with Related Antigens

  1963cited by this paper
• Antibody responses after successive injections of related antigens.

  1963cited by this paper
• Immunological Specificity of the Secondary Response with Dinitrophenylated Proteins.∗

  1963cited by this paper
• Formation of Antibody to Haptens

  1962cited by this paper
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  1962cited by this paper
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  1962cited by this paper
• DELAYED HYPERSENSITIVITY TO HAPTEN-PROTEIN CONJUGATES

  1962cited by this paper
• Internal Antigenic Determinants in Protein Molecules.∗

  1960cited by this paper
• The specificity of allergic reactions. I. Delayed versus Arthus hypersensitivity.

  1960cited by this paper
• Specificity of Allergic Reactions. II. Azoproteins in the Anamnestic Response

  1960cited by this paper
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  1960cited by this paper
• THE IN VIVO STABILITY OF ANTIBODY

  1959cited by this paper
• Immunochemical study of the enzymatic degradation of human serum albumin: an analysis of the antigenic structure of a protein molecule.

  1959cited by this paper
• Studies on hypersensitivity. I. Delayed and Arthustype skin reactivity to protein conjugates in guinea pigs.

  1959cited by this paper
• Specificity of Anamnestic Response in Chickens.∗

  1959cited by this paper
• EFFECT OF SECONDARY INJECTIONS OF ANTIGEN UPON THE RETENTION IN LIVER OF A PRIMARY INJECTION

  1958cited by this paper
• Specificity of the secondary response to protein antigens.

  1955cited by this paper
• The Specificity of Serological Reactions

  1945cited by this paper
• The Serological Properties of Simple Substances. VII. A Quantitative Theory of the Inhibition by Haptens of the Precipitation of Heterogeneous Antisera with Antigens, and Comparison with Experimental Results for Polyhaptenic Simple Substances and for Azoproteins

  1944cited by this paper

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  1993cites this paper
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  1983cites this paper
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  1982cites this paper
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  1979cites this paper
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  1979cites this paper
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  1977cites this paper
• Primary in vitro antibody response from human peripheral blood lymphocytes.

  1977cites this paper
• Antigenic Determinants and Antibody Combining Sites

  1975cites this paper
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  1975cites this paper
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  1975cites this paper
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  1975cites this paper
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  1974cites this paper
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  1974cites this paper
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  1974cites this paper
• Co-operation of thymus and bone marrow cells responding to dinitrophenyl in vivo: further studies on the cellular basis of the 'carrier effect'.

  1973cites this paper
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  1973cites this paper
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  1973cites this paper
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  1973cites this paper
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  1972cites this paper
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  1972cites this paper
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  1972cites this paper
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  1972cites this paper
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  1971cites this paper
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  1971cites this paper
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  1971cites this paper
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  1971cites this paper
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  1971cites this paper
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  1971cites this paper
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