The maintenance and dynamics of memory T-cells in the bone marrow are a matter of ongoing debate. It has been suggested that memory T-cells in the bone marrow are maintained as long-lived, quiescent cells. We have recently shown that memory T-cells isolated from goat bone marrow undergo self-renewal and recirculate via the blood and lymph. Using the well-established memory T-cell markers CD44 and CD62L we here show very similar results in mice. This provides further support for the concept that memory T-cells are continuously self-renewing and recirculating between blood, bone marrow, spleen and lymph nodes.
In vivo deuterium labelling in mice supports a dynamic model for memory T-cell maintenance in the bone marrow.
M. Baliu-Piqué,S. Otto,J. Borghans,K. Tesselaar
Published 2019 in Immunology Letters
ABSTRACT
PUBLICATION RECORD
- Publication year
2019
- Venue
Immunology Letters
- Publication date
2019-06-01
- Fields of study
Biology, Medicine, Chemistry
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
CITATION MAP
EXTRACTION MAP
CLAIMS
CONCEPTS
- blood
The vascular compartment used as one of the routes for memory T-cell movement in the study.
- bone marrow
The hematopoietic tissue inside bones where the memory T-cell population is analyzed.
Aliases: BM
- cd44
A surface marker used to identify memory-phenotype T cells in the study.
- cd62l
A surface marker used with CD44 to classify memory T-cell subsets in the study.
Aliases: L-selectin
- dynamic model for memory t-cell maintenance
A maintenance framework in which memory T-cells are sustained by turnover and movement between compartments.
Aliases: dynamic model
- in vivo deuterium labeling
A stable-isotope labeling approach used to track cell turnover in living mice over time.
Aliases: deuterium labelling, deuterium labeling
- lymph nodes
Secondary lymphoid organs included among the compartments connected by memory T-cell movement.
Aliases: lymph node
- memory t-cells
Antigen-experienced T lymphocytes examined here as a long-lived immune cell population.
Aliases: memory T cells, memory T cell
- recirculation
Movement of cells between anatomical compartments through the blood and lymphatic system.
- self-renewal
Cell proliferation that produces additional cells of the same population.
- spleen
A secondary lymphoid organ included among the compartments connected by memory T-cell movement.
REFERENCES
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CITED BY
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