Biomarker-based MicroRNA Therapeutic Strategies for Hepatocellular Carcinoma

Recently, microRNAs (miRNAs) have emerged as key factors involved in a series of biological processes, ranging from embryogenesis to programmed cell death. Its link to aberrant expression profiles has rendered it a potentially attractive tool for the diagnosis, prognosis, or treatment of various diseases. Accumulating evidence has indicated that miRNAs act as tumor suppressors in hepatocyte malignant transformation by regulating development, differentiation, proliferation, and tumorigenesis. Here, we summarize recent progress in the development of novel biomarker-based miRNA therapeutic strategies for hepatocellular carcinoma (HCC).

• Publication year

  2014

• Venue

  Journal of Clinical and Translational Hepatology

• Publication date

  2014-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.14218/JCTH.2014.00020PMID 26355266PMCID 4521238
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Update on biomarkers of hepatocellular carcinoma.

  2015cited by this paper
• MicroRNA Therapeutics.

  2015cited by this paper
• Alterations of epigenetics and microRNA in hepatocellular carcinoma

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• MicroRNA-148a: a potential therapeutic target for cancer.

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• The Function of miRNA in Hepatic Cancer Stem Cell

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  2013cited by this paper
• MicroRNAs -the Next Generation Therapeutic Targets in Human Diseases

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• Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells.

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  2013cited by this paper
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  2011cited by this paper
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  1986cited by this paper
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