Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivo

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Cancer Biology & Therapy

• Publication date

  2013-09-12

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.4161/cbt.26426PMID 24025355PMCID PMC3925662
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Radiation therapy and esophageal cancer.

  2013influential reference
• Berberine and its derivatives: a patent review (2009 – 2012)

  2013cited by this paper
• Hypoxia-inducible factor 1 mediates the anti-apoptosis of berberine in neurons during hypoxia/ischemia.

  2012cited by this paper
• Berberine: new perspectives for old remedies.

  2012cited by this paper
• Acute versus chronic hypoxia in tumors

  2012cited by this paper
• Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to Improve Radiotherapy Efficacy

  2012cited by this paper
• Microenvironment and Radiation Therapy

  2012cited by this paper
• Antiangiogenic activity of berberine is mediated through the downregulation of hypoxia-inducible factor-1, VEGF, and proinflammatory mediators

  2012cited by this paper
• Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy.

  2012cited by this paper
• Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels

  2012cited by this paper
• Small interfering RNA targeting HIF-1α reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro

  2011cited by this paper
• Berberine Radiosensitizes Human Esophageal Cancer Cells by Downregulating Homologous Recombination Repair Protein RAD51

  2011cited by this paper
• Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells

  2011cited by this paper
• The combination of berberine and irradiation enhances anti‐cancer effects via activation of p38 MAPK pathway and ROS generation in human hepatoma cells

  2009cited by this paper
• Using YC-1 to overcome the radioresistance of hypoxic cancer cells.

  2009cited by this paper
• Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: the contribution of autophagic cell death.

  2008cited by this paper
• Hypoxia: A key regulator of angiogenesis in cancer

  2007cited by this paper
• HIF-1 and tumour radiosensitivity

  2006cited by this paper
• Berberine Inhibits HIF-1α Expression via Enhanced Proteolysis

  2004cited by this paper
• Berberine inhibits HIF-1alpha expression via enhanced proteolysis.

  2004cited by this paper
• Pretreatment evaluation of combined HIF‐1α, p53 and p21 expression is a useful and sensitive indicator of response to radiation and chemotherapy in esophageal cancer

  2004influential reference

• Natural medicines for radioprotection and radiosensitization: a bibliometric analysis of mechanisms and trends (2001–2025)

  2026cites this paper
• Differences in treatment outcome between translational platforms in developing therapies for gastrointestinal cancers.

  2025cites this paper
• Enhancement of radiation effects by Plantago major in MCF-7 human breast cancer: an animal study

  2025cites this paper
• Pharmacological Modulation of Mutant TP53 with Oncotargets Against Esophageal Cancer and Therapy Resistance

  2025cites this paper
• The translational potential of epigenetic modulatory bioactive phytochemicals as adjuvant therapy against cancer.

  2025cites this paper
• Advances in the Pathogenesis and Treatment of Esophageal Cancer with Traditional Chinese Medicine

  2025cites this paper
• Radiotherapy Enhancing and Radioprotective Properties of Berberine: A Systematic Review.

  2024cites this paper
• A Comprehensive Review Highlighting the Prospects of Phytonutrient Berberine as an Anticancer Agent

  2024cites this paper
• Therapeutic implications of signaling pathways and tumor microenvironment interactions in esophageal cancer.

  2024cites this paper
• The therapeutic effects of berberine for gastrointestinal cancers

  2023cites this paper
• Hypoxia‐induced factor‐1α promotes radioresistance of esophageal cancer cells by transcriptionally activating LINC01116 and suppressing miR‐3612 under hypoxia

  2023cites this paper
• Mechanisms of radiotherapy resistance and radiosensitization strategies for esophageal squamous cell carcinoma

  2023cites this paper
• Active Ingredients from Chinese Medicine for Combination Cancer Therapy

  2023cites this paper
• Current Drugs and Their Therapeutic Targets for Hypoxia-inducible Factors in Cancer.

  2023cites this paper
• Current Advances in Coptidis Rhizoma for Gastrointestinal and Other Cancers

  2022cites this paper
• Dietary Phytochemicals Targeting Nrf2 to Enhance the Radiosensitivity of Cancer

  2022cites this paper
• Anticancer mechanisms of Berberine: a good choice for glioblastoma multiforme therapy.

  2022cites this paper
• Combined detection of peripheral blood VEGF and inflammation biomarkers to evaluate the clinical response and prognostic prediction of non-operative ESCC

  2021cites this paper
• CBX4 contributes to radioresistance by regulating autophagic activity in esophageal squamous cell carcinoma

  2021cites this paper
• Ultra-sensitive responsive near-infrared fluorescent nitroreductase probe with strong specificity for imaging tumor and detecting the invasiveness of tumor cells.

  2021cites this paper
• Berberine improves insulin-induced diabetic retinopathy through exclusively suppressing Akt/mTOR-mediated HIF-1α/VEGF activation in retina endothelial cells

  2021cites this paper
• Inhibitory effects of berberine on ovarian cancer: Beyond apoptosis

  2021cites this paper
• New Advances in the Research of Resistance to Neoadjuvant Chemotherapy in Breast Cancer

  2021cites this paper
• Vascular normalization in immunotherapy: A promising mechanisms combined with radiotherapy.

  2021cites this paper
• Metabolic Rewiring in Radiation Oncology Toward Improving the Therapeutic Ratio

  2021cites this paper
• Berberine—A potent chemosensitizer and chemoprotector to conventional cancer therapies

  2021cites this paper
• Cancer cachexia has many symptoms but only one cause: anoxia

  2020cites this paper
• Migration, invasion, invadopodia, and the inversion of the pH gradient

  2020cites this paper
• Patient-derived organoids as individual patient models for chemoradiation response prediction in gastrointestinal malignancies.

  2020cites this paper
• Berberine can amplify cytotoxic effect of radiotherapy by targeting cancer stem cells

  2020cites this paper
• Effect of low dose of berberine on the radioresistance of cervical cancer cells via a PI3K/HIF-1 pathway under nutrient-deprived conditions

  2020cites this paper
• Biological properties and clinical applications of berberine

  2020cites this paper
• Nutraceutical Compounds as Sensitizers for Cancer Treatment in Radiation Therapy

  2019cites this paper
• Therapeutic potential of natural plant products and their metabolites in preventing radiation enteropathy resulting from abdominal or pelvic irradiation

  2019cites this paper
• Berberine enhances the radiosensitivity of hepatoma cells by Nrf2 pathway.

  2019cites this paper
• Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition

  2019cites this paper
• Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments: Role of HIF-1 Network

  2019cites this paper
• Towards diagnostic and therapeutic integration of advanced MR imaging in thoracic and neuro-oncology

  2019cites this paper
• Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

  2019cites this paper
• Herbal nutraceuticals: safe and potent therapeutics to battle tumor hypoxia

  2019cites this paper
• The Critical Role of Hypoxic Microenvironment and Epigenetic Deregulation in Esophageal Cancer Radioresistance

  2019cites this paper
• Preventive and Therapeutic Roles of Berberine in Gastrointestinal Cancers

  2019cites this paper
• Berberine: A potential adjunct for the treatment of gastrointestinal cancers?

  2018cites this paper
• The potential of herb medicines in the treatment of esophageal cancer.

  2018cites this paper
• Berberine as an Adjuvant and Sensitizer to Current Chemotherapy

  2018cites this paper
• Synergistic effect of berberine and HMQ1611 impairs cell proliferation and migration by regulating Wnt signaling pathway in hepatocellular carcinoma

  2018cites this paper
• Berberine Effects on NFκB, HIF1A and NFE2L2/AP-1 Pathways in HeLa Cells.

  2018cites this paper
• Berberine decelerates glucose metabolism via suppression of mTOR‑dependent HIF‑1α protein synthesis in colon cancer cells.

  2018cites this paper
• In vivo evaluation of the effects of simultaneous inhibition of GLUT-1 and HIF-1α by antisense oligodeoxynucleotides on the radiosensitivity of laryngeal carcinoma using micro 18F-FDG PET/CT

  2017cites this paper
• The mechanisms of radioresistance in esophageal squamous cell carcinoma and current strategies in radiosensitivity.

  2017cites this paper
• Berberine sensitizes nasopharyngeal carcinoma cells to radiation through inhibition of Sp1 and EMT.

  2017cites this paper
• Paeonol enhances the sensitivity of human ovarian cancer cells to radiotherapy-induced apoptosis due to downregulation of the phosphatidylinositol-3-kinase/Akt/phosphatase and tensin homolog pathway and inhibition of vascular endothelial growth factor.

  2017cites this paper
• Astaxanthin increases radiosensitivity in esophageal squamous cell carcinoma through inducing apoptosis and G2/M arrest.

  2017cites this paper
• Hypoxia inducible factor down-regulation, cancer and cancer stem cells (CSCs): ongoing success stories.

  2017cites this paper
• Berberine Reverses Hypoxia-induced Chemoresistance in Breast Cancer through the Inhibition of AMPK- HIF-1α

  2017cites this paper
• Nutlin-3, an Antagonist of MDM2, Enhances the Radiosensitivity of Esophageal Squamous Cancer with Wild-Type p53

  2017cites this paper
• HIF-1α: Its Role in Metastasis of Oesophageal Malignancy

  2017cites this paper
• Hypoxia and hypoxia response-associated molecular markers in esophageal cancer: A systematic review.

  2017cites this paper
• Berberine Enhances Chemosensitivity and Induces Apoptosis Through Dose-orchestrated AMPK Signaling in Breast Cancer

  2017cites this paper
• Novel poly (ADP-ribose) polymerase inhibitor, AZD2281, enhances radiosensitivity of both normoxic and hypoxic esophageal squamous cancer cells.

  2016cites this paper
• Synthesis of Mannich base derivatives of berberine and evaluation of their anticancer and antioxidant effects

  2016cites this paper
• VEGFR2 inhibition by RNA interference affects cell proliferation, migration, invasion, and response to radiation in Calu-1 cells

  2016cites this paper
• eEF2K promotes progression and radioresistance of esophageal squamous cell carcinoma.

  2016cites this paper
• Role of Berberine on molecular markers involved in migration of esophageal cancer cells.

  2015cites this paper
• Hypoxia-inducible factor-1α expression in the different stages of rat thromboangiitis obliterans.

  2015cites this paper
• Berberine and Coptidis Rhizoma as potential anticancer agents: Recent updates and future perspectives.

  2015cites this paper
• The Natural Compound Gambogic Acid Radiosensitizes Nasopharyngeal Carcinoma Cells under Hypoxic Conditions

  2015cites this paper
• Recent Advances in Nucleic Acid Binding Aspects of Berberine Analogs and Implications for Drug Design.

  2015cites this paper
• STAT3 inhibitor stattic enhances radiosensitivity in esophageal squamous cell carcinoma

  2015cites this paper
• Metformin enhances radiation response of ECa109 cells through activation of ATM and AMPK.

  2015cites this paper
• Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid

  2014cites this paper
• STAT3 inhibitor NSC74859 radiosensitizes esophageal cancer via the downregulation of HIF-1α

  2014cites this paper
• Melittin enhances radiosensitivity of hypoxic head and neck squamous cell carcinoma by suppressing HIF-1α

  2014cites this paper
• High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors

  2014cites this paper
• Berberine, an Epiphany Against Cancer

  2014cites this paper