A novel MyD-1 (SIRP-1alpha) signaling pathway that inhibits LPS-induced TNFalpha production by monocytes.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Blood

• Publication date

  2003-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD-2002-11-3596PMID 12805067
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68.

  2003cited by this paper
• The Phosphatidylinositol 3-Kinase-Akt Pathway Limits Lipopolysaccharide Activation of Signaling Pathways and Expression of Inflammatory Mediators in Human Monocytic Cells*

  2002cited by this paper
• Molecular action of methotrexate in inflammatory diseases

  2002cited by this paper
• MyD-1 (SIRPalpha) regulates T cell function in the absence of exogenous danger signals, via a TNFalpha-dependent pathway.

  2002cited by this paper
• MyD‐1 (SIRPα) regulates T cell function in the absence of exogenous danger signals, via a TNFα‐dependent pathway

  2002cited by this paper
• MyD88 as a bottle neck in Toll/IL-1 signaling.

  2002cited by this paper
• Mycophenolic acid and methotrexate inhibit lymphocyte cytokine production via different mechanisms.

  2002cited by this paper
• Toll-like receptors and their ligands.

  2002cited by this paper
• TLR4 as the mammalian endotoxin sensor.

  2002cited by this paper
• Bidirectional Negative Regulation of Human T and Dendritic Cells by CD47 and Its Cognate Receptor Signal-Regulator Protein-α: Down-Regulation of IL-12 Responsiveness and Inhibition of Dendritic Cell Activation1

  2001cited by this paper
• Stimulation-induced down-regulation of tumor necrosis factor-alpha converting enzyme.

  2000cited by this paper
• Stimulation-induced Down-regulation of Tumor Necrosis Factor-α Converting Enzyme*

  2000cited by this paper
• Molecular Mechanism for the Shp-2 Tyrosine Phosphatase Function in Promoting Growth Factor Stimulation of Erk Activity

  2000cited by this paper
• CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPα 1

  2000cited by this paper
• Adamalysins. A family of metzincins including TNF-alpha converting enzyme (TACE).

  1999cited by this paper
• Adamalysins: A Family of Metzincins Including TNF‐α Converting Enzyme (TACE)

  1999cited by this paper
• Methotrexate inhibits LPS-induced tumor necrosis factor production in vivo.

  1999cited by this paper
• Polymorphism of the human TNF-α promoter — random variation or functional diversity?

  1999cited by this paper
• Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP

  1999cited by this paper
• IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98-kDa protein associated with SHP-2, phosphatidylinositol 3'-kinase, and Grb2.

  1999cited by this paper
• Integrin-associated Protein Is a Ligand for the P84 Neural Adhesion Molecule*

  1999cited by this paper
• Polymorphism of the human TNF-alpha promoter--random variation or functional diversity?

  1999cited by this paper
• Endocytosis and vesicular trafficking of immune complexes and activation of phospholipase D by the human high-affinity IgG receptor requires distinct phosphoinositide 3-kinase activities.

  1999cited by this paper
• Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen‐induced arthritis (CIA): a mechanism for methotrexate‐mediated immunosuppression

  1999cited by this paper
• Recognition of gram-negative bacteria and endotoxin by the innate immune system.

  1999cited by this paper
• Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction.

  1998cited by this paper
• Regulation of B cell signal transduction by SH2-containing protein-tyrosine phosphatases.

  1998cited by this paper
• Cloning of two members of the SIRPα family of protein tyrosine phosphatase binding proteins in cattle that are expressed on monocytes and a subpopulation of dendritic cells and which mediate binding to CD4 T cells

  1998cited by this paper
• Aggregation of the human high affinity immunoglobulin G receptor (FcgammaRI) activates both tyrosine kinase and G protein-coupled phosphoinositide 3-kinase isoforms.

  1998cited by this paper
• FcγRI Coupling to Phospholipase D Initiates Sphingosine Kinase-mediated Calcium Mobilization and Vesicular Trafficking*

  1998cited by this paper
• Integrin-mediated Tyrosine Phosphorylation of SHPS-1 and Its Association with SHP-2

  1998cited by this paper
• Growth Hormone Regulation of SIRP and SHP-2 Tyrosyl Phosphorylation and Association*

  1998cited by this paper
• A molecular switch changes the signalling pathway used by the Fc gamma RI antibody receptor to mobilise calcium.

  1998cited by this paper
• High Expression of Inhibitory Receptor SHPS-1 and Its Association with Protein-tyrosine Phosphatase SHP-1 in Macrophages*

  1998cited by this paper
• Conservation of structural features reveals the existence of a large family of inhibitory cell surface receptors and noninhibitory/activatory counterparts.

  1997cited by this paper
• A family of proteins that inhibit signalling through tyrosine kinase receptors

  1997cited by this paper
• A phosphorylcholine-containing filarial nematode-secreted product disrupts B lymphocyte activation by targeting key proliferative signaling pathways.

  1997cited by this paper
• T cell stimulation via CD47: agonistic and antagonistic effects of CD47 monoclonal antibody 1/1A4.

  1997cited by this paper
• Characterization of a Novel Tyrosine Phosphorylated 100-kDa Protein That Binds to SHP-2 and Phosphatidylinositol 3′-Kinase in Myeloid Cells*

  1997cited by this paper
• Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal localization of genes.

  1997cited by this paper
• Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype.

  1997cited by this paper
• Interleukin-3 Induces Association of the Protein-tyrosine Phosphatase SHP2 and Phosphatidylinositol 3-Kinase with a 100-kDa Tyrosine-phosphorylated Protein in Hemopoietic Cells*

  1997cited by this paper
• Costimulation of T Cell Activation by Integrin-associated Protein (CD47) Is an Adhesion-dependent, CD28-independent Signaling Pathway

  1997cited by this paper
• Molecular and functional characteristics of dendritic cells generated from highly purified CD14+ peripheral blood monocytes.

  1996cited by this paper
• Gene polymorphism at position -308 of the tumor-necrosis-factor-alpha (TNF-alpha) in multiple sclerosis and it's influence on the regulation of TNF-alpha production.

  1996cited by this paper
• Gene polymorphism at position −308 of the tumor-necrosis -factor-α (TNF-α) in Multiple Sclerosis and it's influence on the regulation of TNF-α production

  1996cited by this paper
• A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion

  1996cited by this paper
• Variation in the tumor necrosis factor-alpha gene promoter region may be associated with death from meningococcal disease.

  1996cited by this paper
• Increased frequency of the uncommon allele of a tumour necrosis factor alpha gene polymorphism in rheumatoid arthritis and systemic lupus erythematosus.

  1995cited by this paper
• Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events

  1995cited by this paper
• Auranofin inhibits the induction of interleukin 1β and tumor necrosis factor α mRNA in macrophages

  1995cited by this paper
• A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses.

  1995cited by this paper
• Auranofin inhibits the induction of interleukin 1 beta and tumor necrosis factor alpha mRNA in macrophages.

  1995cited by this paper
• Effect of Three Lipophilic Methotrexate Derivatives Upon Mediator Release by Lipopolysaccharide‐stimulated Rat Peritoneal Macrophages

  1994cited by this paper
• The acute phase response.

  1994cited by this paper
• Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3.

  1994cited by this paper
• A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells.

  1994cited by this paper
• Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

  1993cited by this paper
• Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.

  1992cited by this paper
• Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil

  1991cited by this paper
• Bovine afferent lymph veiled cells differ from blood monocytes in phenotype and accessory function.

  1991cited by this paper

• SIRPB1 is transcriptionally regulated by USF2 and promotes cutaneous malignant melanoma tumorigenicity through SOCS1/STAT3 signaling

  2025cites this paper
• Neuroimmune pathways involvement in neurodegeneration of R6/2 mouse model of Huntington’s disease

  2024cites this paper
• Modulation of Signal Regulatory Protein α (SIRPα) by Plasmodium Antigenic Extract: A Preliminary In Vitro Study on Peripheral Blood Mononuclear Cells

  2022cites this paper
• Detection of Immune Checkpoint Receptors – A Current Challenge in Clinical Flow Cytometry

  2021cites this paper
• Resveratrol attenuates TLR-4 mediated inflammation and elicits therapeutic potential in models of sepsis

  2020cites this paper
• The prion protein in neuroimmune crosstalk.

  2019cites this paper
• Tyrosine phosphorylation of the transmembrane protein SIRPα: Sensing synaptic activity and regulating ectodomain cleavage for synapse maturation

  2018cites this paper
• ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile

  2018cites this paper
• Detection of Signal Regulatory Protein α in Saimiri sciureus (Squirrel Monkey) by Anti-Human Monoclonal Antibody

  2017cites this paper
• Microglia in Alzheimer's disease.

  2017cites this paper
• CNS inflammation and neurodegeneration.

  2017cites this paper
• α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology

  2016cites this paper
• Cancer stem cells and tumor-associated macrophages: a roadmap for multitargeting strategies

  2016cites this paper
• Donor Lymphocyte Infusion-Mediated Graft-versus-Host Responses in a Preclinical Swine Model of Haploidentical Hematopoietic Cell Transplantation.

  2016cites this paper
• Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

  2015cites this paper
• SIRP/CD47 signaling in neurological disorders.

  2015cites this paper
• Inflammation in Alzheimer's Disease: Cross-talk between Lipids and Innate Immune Cells of the Brain

  2015cites this paper
• Pathological differences between white and grey matter multiple sclerosis lesions

  2015cites this paper
• The Blood-Brain Barrier and the Immune Privilege of the Central Nervous System

  2015cites this paper
• Neuronal influence behind the central nervous system regulation of the immune cells

  2013cites this paper
• Receptor usage by the Acanthocheilonema viteae-derived immunomodulator, ES-62.

  2012cites this paper
• Lack of antidonor alloantibody does not indicate lack of immune sensitization: studies of graft loss in a haploidentical hematopoietic cell transplantation swine model.

  2012cites this paper
• Neuroimmune crosstalk in the central nervous system and its significance for neurological diseases

  2012cites this paper
• Surfactant Protein D (Sp-D) Binds to Membrane-proximal Domain (D3) of Signal Regulatory Protein α (SIRPα), a Site Distant from Binding Domain of CD47, while Also Binding to Analogous Region on Signal Regulatory Protein β (SIRPβ)*

  2012cites this paper
• Rôle des mastocytes dans le développement des astrocytomes humains : implication du récepteur CD47

  2012cites this paper
• Immune Characterization of Wild-Caught Rattus norvegicus Suggests Diversity of Immune Activity in Biome-Normal Environments

  2012cites this paper
• The regulation of lung homeostasis and influenza-associated inflammation

  2011cites this paper
• Signal Regulatory Protein-a signaling is essential for splenic CD8- dendritic cell migration and homeostasis

  2011cites this paper
• Negative regulation of inflammatory responses by immunoglobulin A receptor (FcαRI) inhibits the development of Toll‐like receptor‐9 signalling‐accelerated glomerulonephritis

  2011cites this paper
• The Role of cis Dimerization of Signal Regulatory Protein α (SIRPα) in Binding to CD47*

  2010cites this paper
• Sphingosine 1-phosphate and cancer

  2010cites this paper
• Signal Inhibitory Receptor on Leukocytes-1 Is a Novel Functional Inhibitory Immune Receptor Expressed on Human Phagocytes

  2010cites this paper
• Preparation and preliminary application of a novel monoclonal antibody against human SIRPα: Preparation and preliminary application of a novel monoclonal antibody against human SIRPα

  2010cites this paper
• Receptor Expressed on Human Phagocytes Is a Novel Functional Inhibitory Immune Signal Inhibitory Receptor on Leukocytes-1

  2010cites this paper
• Immune activation in brain aging and neurodegeneration: too much or too little?

  2009cites this paper
• Leucocyte‐associated immunoglobulin‐like receptor‐1 is an inhibitory regulator of contact hypersensitivity

  2009cites this paper
• Temporal aspects of laminar gene expression during the developmental stages of equine laminitis.

  2009cites this paper
• Neuronal regulation of immune responses in the central nervous system.

  2009cites this paper
• Tetraspanin CD9 Negatively Regulates Lipopolysaccharide-Induced Macrophage Activation and Lung Inflammation1

  2009cites this paper
• Tetraspanin CD 9 Negatively Regulates Lipopolysaccharide-Induced Macrophage Activation and Lung Inflammation 1

  2009influential citation
• The Inhibitory FcγIIb Receptor Dampens TLR4-Mediated Immune Responses and Is Selectively Up-regulated on Dendritic Cells from Rheumatoid Arthritis Patients with Quiescent Disease1

  2009cites this paper
• Signal regulatory protein alpha negatively regulates both TLR3 and cytoplasmic pathways in type I interferon induction.

  2008cites this paper
• Inhibition of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 Reduces the Severity of Collagen-Induced Arthritis

  2008cites this paper
• Signal Regulatory Protein α Negatively Regulates β2 Integrin-Mediated Monocyte Adhesion, Transendothelial Migration and Phagocytosis

  2008cites this paper
• Dynamic Expression of the Signal Regulatory Protein α and CD18 on Porcine PBMC During Acute Endotoxaemia

  2008cites this paper
• Role of the CD47/SIRPα-interaction in regulation of macrophage phagocytosis

  2008cites this paper
• Overcoming skin rejection in composite tissue allotransplantation.

  2008cites this paper
• Phosphatase Substrate-1 Reduces the Severity of Collagen-Induced Arthritis Inhibition of Src Homology 2 Domain-Containing Protein Tyrosine

  2008cites this paper
• LPS-induced down-regulation of signal regulatory protein α contributes to innate immune activation in macrophages

  2007cites this paper
• Microglial control of neuronal death and synaptic properties

  2007cites this paper
• Molecular cloning characterization and expression of porcine immunoreceptor SIRPα

  2007cites this paper
• Phospholipase D, perméabilité endothéliale, et apoptose TNFα dépendante

  2007cites this paper
• Molecular cloning characterization and expression of porcine immunoreceptor SIRPalpha.

  2007cites this paper
• Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells

  2007cites this paper
• Sphingosine kinase: biochemical and cellular regulation and role in disease.

  2006influential citation
• Predictors of Organ Allograft Tolerance Following Hematopoietic Cell Transplantation

  2006cites this paper
• Differential detergent fractionation for non-electrophoretic bovine peripheral blood monocyte proteomics reveals proteins involved in professional antigen presentation.

  2006cites this paper
• Signal Regulatory Protein Molecules Are Differentially Expressed by CD8− Dendritic Cells1

  2006cites this paper
• Proteins injected by the bacterial pathogen "Bartonella" subvert eukaryotic cell signaling

  2006cites this paper
• IgE-dependent Activation of Sphingosine Kinases 1 and 2 and Secretion of Sphingosine 1-Phosphate Requires Fyn Kinase and Contributes to Mast Cell Responses*

  2006cites this paper
• The role of dendritic cells in response to cytokine gene adjuvants

  2006cites this paper
• Stable Multilineage Chimerism without Graft versus Host Disease Following Nonmyeloablative Haploidentical Hematopoietic Cell Transplantation

  2006cites this paper
• The SIRP family of receptors and immune regulation.

  2006cites this paper
• Human 6-sulfo LacNAc-expressing dendritic cells are principal producers of early interleukin-12 and are controlled by erythrocytes.

  2006cites this paper
• Negative regulators of toll-like receptor 4-mediated macrophage inflammatory response.

  2006cites this paper
• The SIRP family of receptors and immune regulation

  2006cites this paper
• Activation of Human Dendritic Cells Osteoclast-Associated Receptor-Mediated Transcript 2 ) Inhibits Human CD 85 j ( Leukocyte Ig-Like Receptor-1 / Ig-Like

  2005cites this paper
• Analysis of Immune Responses Directed toward a Recombinant Early Secretory Antigenic Target Six-Kilodalton Protein-Culture Filtrate Protein 10 Fusion Protein in Mycobacterium bovis-Infected Cattle

  2005influential citation
• Mechanisms of LAIR-1 mediated inhibition of immune function

  2005cites this paper
• CD85j (Leukocyte Ig-Like Receptor-1/Ig-Like Transcript 2) Inhibits Human Osteoclast-Associated Receptor-Mediated Activation of Human Dendritic Cells1

  2005cites this paper
• Signaling by ITIM-bearing receptors

  2005cites this paper
• Signal Regulatory Proteins in the Immune System

  2005cites this paper
• Signal Regulatory Protein α Ligation Induces Macrophage Nitric Oxide Production through JAK/STAT- and Phosphatidylinositol 3-Kinase/Rac1/NAPDH Oxidase/H2O2-Dependent Pathways

  2005cites this paper
• Contribution of in vivo and ex vivo studies to understanding the role of antigen-presenting cells and T cell subsets in immunity to cattle diseases

  2004cites this paper
• Human Lymphocytes Interact Directly with CD47 through a Novel Member of the Signal Regulatory Protein (SIRP) Family1

  2004cites this paper
• Interaction of antigen presenting cells with mycobacteria.

  2004cites this paper
• The role of dendritic cells in shaping the immune response

  2004cites this paper
• Gene expression in mononuclear cells from patients with inflammatory bowel disease.

  2004cites this paper