Engineering of a Human Vaginal Lactobacillus Strain for Surface Expression of Two-Domain CD4 Molecules

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Applied and Environmental Microbiology

• Publication date

  2008-04-21

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1128/AEM.00104-08PMID 18539799PMCID PMC2504410
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Lactobacilli-Expressed Single-Chain Variable Fragment (scFv) Specific for Intercellular Adhesion Molecule 1 (ICAM-1) Blocks Cell-Associated HIV-1 Transmission across a Cervical Epithelial Monolayer1

  2006cited by this paper
• Engineered Vaginal Lactobacillus Strain for Mucosal Delivery of the Human Immunodeficiency Virus Inhibitor Cyanovirin-N

  2006influential reference
• Lactobacilli expressing variable domain of llama heavy-chain antibody fragments (lactobodies) confer protection against rotavirus-induced diarrhea.

  2006cited by this paper
• Genital tract shedding of herpes simplex virus type 2 in women: effects of hormonal contraception, bacterial vaginosis, and vaginal group B Streptococcus colonization.

  2005cited by this paper
• Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus–cell fusion

  2005cited by this paper
• Female genital-tract HIV load correlates inversely with Lactobacillus species but positively with bacterial vaginosis and Mycoplasma hominis.

  2005cited by this paper
• Prevention of Vaginal SHIV Transmission in Rhesus Macaques Through Inhibition of CCR5

  2004cited by this paper
• Characterization of vaginal microbial communities in adult healthy women using cultivation-independent methods.

  2004cited by this paper
• Inhibition of HIV infectivity by a natural human isolate of Lactobacillus jensenii engineered to express functional two-domain CD4

  2003influential reference
• Role of Mobile DNA in the Evolution of Vancomycin-Resistant Enterococcus faecalis

  2003cited by this paper
• Neutralization of Human Immunodeficiency Virus Type 1 by sCD4-17b, a Single-Chain Chimeric Protein, Based on Sequential Interaction of gp120 with CD4 and Coreceptor

  2003cited by this paper
• Complete genome sequence of Lactobacillus plantarum WCFS1

  2003cited by this paper
• Inhibiting sexual transmission of HIV-1 infection

  2003cited by this paper
• MICROBICIDES:Raising New Barriers Against HIVInfection

  2003cited by this paper
• The microbicide cyanovirin-N expressed on the surface of commensal bacterium Streptococcus gordonii captures HIV-1

  2002cited by this paper
• Biochemical and Biological Characterization of a Dodecameric CD4-Ig Fusion Protein

  2002cited by this paper
• HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

  2002influential reference
• Vaginal Lactobacillus Flora of Healthy Swedish Women

  2002cited by this paper
• Considerations and development of topical microbicides to inhibit the sexual transmission of HIV

  2002cited by this paper
• Characterization of a cryptic plasmid from Lactobacillus fermentum KC5b and its use for constructing a stable Lactobacillus cloning vector.

  2002cited by this paper
• Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms

  2002cited by this paper
• In situ delivery of passive immunity by lactobacilli producing single-chain antibodies

  2002cited by this paper
• Binding of LFA-1 (CD11a) to Intercellular Adhesion Molecule 3 (ICAM-3; CD50) and ICAM-2 (CD102) Triggers Transmigration of Human Immunodeficiency Virus Type 1-Infected Monocytes through Mucosal Epithelial Cells

  2002cited by this paper
• A high-molecular-mass cell-surface protein from Lactobacillus reuteri 1063 adheres to mucus components.

  2002cited by this paper
• Protein Design of an HIV-1 Entry Inhibitor

  2001cited by this paper
• Viral burden in genital secretions determines male-to-female sexual transmission of HIV-1: a probabilistic empiric model

  2001cited by this paper
• Design of a Protein-Targeting System for Lactic Acid Bacteria

  2001cited by this paper
• Sequential CD4-Coreceptor Interactions in Human Immunodeficiency Virus Type 1 Env Function: Soluble CD4 Activates Env for Coreceptor-Dependent Fusion and Reveals Blocking Activities of Antibodies against Cryptic Conserved Epitopes on gp120

  2000cited by this paper
• Therapy of mucosal candidiasis by expression of an anti-idiotype in human commensal bacteria

  2000cited by this paper
• DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.

  2000cited by this paper
• Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells.

  1999cited by this paper
• The identification of vaginal Lactobacillus species and the demographic and microbiologic characteristics of women colonized by these species.

  1999cited by this paper
• Surface Proteins of Gram-Positive Bacteria and Mechanisms of Their Targeting to the Cell Wall Envelope

  1999influential reference
• Acquired antibiotic resistance in lactic acid bacteria from food

  1999cited by this paper
• Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

  1998cited by this paper
• Bacterial vaginosis and disturbances of vaginal flora: association with increased acquisition of HIV

  1998cited by this paper
• Cell wall anchoring of the Streptococcus pyogenes M6 protein in various lactic acid bacteria

  1997cited by this paper
• Sexual transmission of HIV.

  1997cited by this paper
• In vivo immobilization of enzymatically active polypeptides on the cell surface of Staphylococcus carnosus

  1996cited by this paper
• Mucosal and systemic immune responses to a recombinant protein expressed on the surface of the oral commensal bacterium Streptococcus gordonii after oral colonization.

  1995cited by this paper
• Resistance of a human serum-selected human immunodeficiency virus type 1 escape mutant to neutralization by CD4 binding site monoclonal antibodies is conferred by a single amino acid change in gp120

  1993cited by this paper
• Cloning, sequencing and expression of the gene encoding the cell-envelope-associated proteinase from Lactobacillus paracasei subsp. paracasei NCDO 151.

  1992cited by this paper
• Viricidal effect of Lactobacillus acidophilus on human immunodeficiency virus type 1: possible role in heterosexual transmission

  1991cited by this paper
• Emerging role of lactobacilli in the control and maintenance of the vaginal bacterial microflora.

  1990cited by this paper
• Female to male: an inefficient mode of transmission of human immunodeficiency virus (HIV)

  1990cited by this paper
• Conservation of a hexapeptide sequence in the anchor region of surface proteins from Gram‐positive cocci

  1990cited by this paper
• Crystal structure of an HIV-binding recombinant fragment of human CD4

  1990cited by this paper
• Crystal structure of an HIV-binding recombinant fragment of human CD4.

  1990cited by this paper
• Identification of the residues in human CD4 critical for the binding of HIV.

  1989cited by this paper
• soluble form of CD4 (T4) protein inhibits AIDS virus infection

  1988cited by this paper
• A soluble recombinant polypeptide comprising the amino-terminal half of the extracellular region of the CD4 molecule contains an active binding site for human immunodeficiency virus.

  1988cited by this paper
• Complete nucleotide sequence of type 6 M protein of the group A Streptococcus. Repetitive structure and membrane anchor.

  1986cited by this paper

• Metabolic engineering of Lactobacilli spp. for disease treatment

  2025cites this paper
• Research and application of intelligent diagnosis and treatment engineering bacteria

  2024cites this paper
• Engineered live bacteria suppress Pseudomonas aeruginosa infection in mouse lung and dissolve endotracheal-tube biofilms

  2023cites this paper
• Designer probiotics: Opening the new horizon in diagnosis and prevention of human diseases

  2023cites this paper
• Blocking HIV-1 Infection by Chromosomal Integrative Expression of Human CD4 on the Surface of Lactobacillus acidophilus ATCC 4356

  2019cites this paper
• Comparison of plasmids from clinical Lactobacillus strains

  2018influential citation
• Current State of Microbicide Development

  2018cites this paper
• Bioengineered intravaginal isolate of Lactobacillus plantarum expresses algal lectin scytovirin demonstrating anti-HIV-1 activity.

  2018cites this paper
• Pharmaceutical Approaches to HIV Treatment and Prevention

  2018cites this paper
• Synthetic biology strategies towards the development of new bioinspired technologies for medical applications

  2017cites this paper
• The Holy Grail of Designer Probiotics: The Probiotics with Multiple Health

  2016cites this paper
• The Holy Grail of Designer Probiotics: The Probiotics withMultiple Health Benefits

  2016cites this paper
• Bioengineered probiotics as a new hope for health and diseases: an overview of potential and prospects.

  2016cites this paper
• Display of a β-mannanase and a chitosanase on the cell surface of Lactobacillus plantarum towards the development of whole-cell biocatalysts

  2016cites this paper
• Escherichia coli surface display of single-chain antibody VRC01 against HIV-1 infection.

  2015cites this paper
• Robust Vaginal Colonization of Macaques with a Novel Vaginally Disintegrating Tablet Containing a Live Biotherapeutic Product to Prevent HIV Infection in Women

  2015cites this paper
• Antiviral Activity of a Single-Domain Antibody Immunotoxin Binding to Glycoprotein D of Herpes Simplex Virus 2

  2014cites this paper
• Microbicides for the Prevention of HIV

  2014cites this paper
• Modified microbiota for microbicide drug delivery

  2014cites this paper
• Antiviral Activity of Single Domain Antibody Immunotoxin Binding to Glycoprotein D of 1 Herpes Simplex Virus 2 2 3 Running Title : VHH-Immunotoxin Targeting HSV-2 Infected Cells

  2014cites this paper
• Protein-based HIV-1 microbicides.

  2014cites this paper
• Clinical use of vaginal or rectally applied microbicides in patients suffering from HIV/AIDS

  2013cites this paper
• Lactobacillus: host-microbe relationships.

  2013cites this paper
• Vaginal microbiota and its role in HIV transmission and infection.

  2013cites this paper
• Surface Display of N-Terminally Anchored Invasin by Lactobacillus plantarum Activates NF-κB in Monocytes

  2012cites this paper
• Genetically Engineered Lactobacilli for Technological and Functional Food Applications

  2012cites this paper
• Probiotic and prebiotic applications for vaginal health.

  2012cites this paper
• Recent advances in anogenital antiretroviral microbicides and multimodal delivery systems.

  2012cites this paper
• Recombinant Probiotic Expressing Listeria Adhesion Protein Attenuates Listeria monocytogenes Virulence In Vitro

  2012influential citation
• Novel surface display system for heterogonous proteins on Lactobacillus plantarum

  2011cites this paper
• Heterologous protein display on the cell surface of lactic acid bacteria mediated by the s-layer protein

  2011cites this paper
• Identification of predominant culturable vaginal Lactobacillus species and associated bacteriophages from women with and without vaginal discharge syndrome in South Africa.

  2011cites this paper
• Plasmid Transduction Using Bacteriophage Φadh for Expression of CC Chemokines by Lactobacillus gasseri ADH

  2010cites this paper
• Engineering of Lactobacillus jensenii to secrete RANTES and a

  2010cites this paper
• Targeting Trojan Horse leukocytes for HIV prevention

  2010cites this paper
• Development of an HIV-1 Specific Microbicide Using Caulobacter crescentus S-Layer Mediated Display of CD4 and MIP1α

  2010cites this paper
• sCD4-17b bifunctional protein: Extremely broad and potent neutralization of HIV-1 Env pseudotyped viruses from genetically diverse primary isolates

  2010cites this paper
• Vaccines and Anti-Infective Agents: Delivery via Lactic Acid Bacteria

  2010cites this paper
• Intestinal bacteria and the regulation of immune cell homeostasis.

  2010cites this paper
• Engineering of Lactobacillus jensenii To Secrete RANTES and a CCR5 Antagonist Analogue as Live HIV-1 Blockers

  2010influential citation
• Microbial ecology of Lactobacillus strains in the chicken gastrointestinal tract : identification of persistent strains for use as live vectors

  2010cites this paper
• Characterization of a Novel LysM Domain from Lactobacillus fermentum Bacteriophage Endolysin and Its Use as an Anchor To Display Heterologous Proteins on the Surfaces of Lactic Acid Bacteria

  2010cites this paper
• Immunoprotective analysis of VhhP2, a Vibrio harveyi vaccine candidate.

  2009cites this paper
• The superior folding of a RANTES analogue expressed in lactobacilli as compared to mammalian cells reveals a promising system to screen new RANTES mutants.

  2009cites this paper
• Characterisation of llama antibody fragments able to act as HIV-1 entry inhibitors

  2009cites this paper
• A Chinese rhesus macaque (Macaca mulatta) model for vaginal Lactobacillus colonization and live microbicide development

  2009cites this paper
• Retrocyclin, A Potent Hiv-1 Entry Inhibitor

  2009cites this paper
• Identification of restriction endonuclease with potential ability to cleave the HSV-2 genome: Inherent potential for biosynthetic versus live recombinant microbicides

  2008cites this paper