A novel mechanism regulating insulin secretion involving Herpud1 in mice

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Diabetologia

• Publication date

  2013-04-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00125-013-2908-yPMID 23620059
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010influential reference
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  2008cited by this paper
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  2007influential reference
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  2006influential reference
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• Familial hyperinsulinism caused by an activating glucokinase mutation.

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  1988cited by this paper
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  1981cited by this paper
• Recombinant Inbred Strains

  1979cited by this paper
• Recombinant Inbred Strains

  1978cited by this paper
• Symposium IV: Diabetic syndrome in animals. Influence of genetic background on the expression of mutations at the diabetes locus in the mouse. II. Studies on background modifiers.

  1975cited by this paper

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  2020cites this paper
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  2020cites this paper
• Targeted pharmacological therapy restores β-cell function for diabetes remission

  2020cites this paper
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  2016cites this paper
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