Paradoxical effects of the endocannabinoid uptake inhibitor VDM11 on accumbal neural encoding of reward predictive cues

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Synapse

• Publication date

  2012-11-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1002/syn.21587PMID 22807176PMCID PMC3440520
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2012influential reference
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