Crystal structures of ferrous and CO-, CN(-)-, and NO-bound forms of rat heme oxygenase-1 (HO-1) in complex with heme: structural implications for discrimination between CO and O2 in HO-1.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Biochemistry

• Publication date

  2003-08-26

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI027268IPMID 12924938
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interaction of Nitric Oxide with Human Heme Oxygenase-1*

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  1999cited by this paper
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  1999cited by this paper
• Nitric oxide myoglobin: Crystal structure and analysis of ligand geometry

  1998cited by this paper
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  1998cited by this paper
• Crystallography & NMR system: A new software suite for macromolecular structure determination.

  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
• Cloning and expression of cDNA for soluble form of rat heme oxygenase-1.

  1996cited by this paper
• Heme-heme oxygenase complex: structure and properties of the catalytic site from resonance Raman scattering.

  1994cited by this paper
• Structural determinants of the stretching frequency of CO bound to myoglobin.

  1994cited by this paper
• Resonance Raman and EPR spectroscopic studies on heme-heme oxygenase complexes.

  1993cited by this paper
• Neutron diffraction study of carbonmonoxymyoglobin.

  1991cited by this paper
• Structural transitions upon ligand binding in a cooperative dimeric hemoglobin.

  1990cited by this paper
• Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications

  1988cited by this paper
• Neutron diffraction reveals oxygen–histidine hydrogen bond in oxymyoglobin

  1981cited by this paper
• A new intermediate of heme degradation catalyzed by the heme oxygenase system.

  1980cited by this paper
• Cooperativity in the dissociation of nitric oxide from hemoglobin.

  1976cited by this paper
• Microsomal heme oxygenase. Characterization of the enzyme.

  1969cited by this paper
• The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.

  1968cited by this paper

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