Ablation of MEK Kinase 1 Suppresses Intimal Hyperplasia by Impairing Smooth Muscle Cell Migration and Urokinase Plasminogen Activator Expression in a Mouse Blood-Flow Cessation Model

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Circulation

• Publication date

  2005-04-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/01.CIR.0000160350.20810.0FPMID 15795331
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter element and endogenous gene transcription.

  2004cited by this paper
• The control of cell motility and epithelial morphogenesis by Jun kinases.

  2004cited by this paper
• ERK activation propagates in epithelial cell sheets and regulates their migration during wound healing.

  2004cited by this paper
• Interactions Between p38 Mitogen-Activated Protein Kinase and Caspase-3 in Cerebral Endothelial Cell Death After Hypoxia-Reoxygenation

  2003cited by this paper
• Activation of Apoptosis Signal-Regulating Kinase 1 in Injured Artery and Its Critical Role in Neointimal Hyperplasia

  2003cited by this paper
• MEKK1 regulates calpain‐dependent proteolysis of focal adhesion proteins for rear‐end detachment of migrating fibroblasts

  2003cited by this paper
• Central role of RAGE-dependent neointimal expansion in arterial restenosis.

  2003cited by this paper
• Deficiency of Gelatinase A Suppresses Smooth Muscle Cell Invasion and Development of Experimental Intimal Hyperplasia

  2003cited by this paper
• Up-regulation of urokinase-type plasminogen activator in corneal epithelial cells induced by wounding.

  2003cited by this paper
• MEK Kinase 1 Interacts with Focal Adhesion Kinase and Regulates Insulin Receptor Substrate-1 Expression*

  2003cited by this paper
• MEKK1 Is Required for Inducible Urokinase-type Plasminogen Activator Expression*

  2003cited by this paper
• MEK kinase 1 regulates c-Jun phosphorylation in the control of corneal morphogenesis.

  2003cited by this paper
• Epidermal Growth Factor Receptor-dependent and -independent Cell-signaling Pathways Originating from the Urokinase Receptor*

  2003cited by this paper
• Different Mechanisms of Increased Luminal Stenosis After Arterial Injury in Mice Deficient for Urokinase- or Tissue-Type Plasminogen Activator

  2002cited by this paper
• The lamellipodium: where motility begins.

  2002cited by this paper
• MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq

  2002cited by this paper
• Vascular Endothelin-B Receptor System In Vivo Plays a Favorable Inhibitory Role in Vascular Remodeling After Injury Revealed by Endothelin-B Receptor–Knockout Mice

  2002cited by this paper
• Spatial regulation of actin dynamics: a tropomyosin-free, actin-rich compartment at the leading edge

  2002cited by this paper
• Targeted Disruption of the Matrix Metalloproteinase-9 Gene Impairs Smooth Muscle Cell Migration and Geometrical Arterial Remodeling

  2002cited by this paper
• In vivo suppression of restenosis in balloon-injured rat carotid artery by adenovirus-mediated gene transfer of the cell surface-directed plasmin inhibitor ATF.BPTI

  2001cited by this paper
• Extracellular Nucleotides Induce Arterial Smooth Muscle Cell Migration Via Osteopontin

  2001cited by this paper
• Molecular mechanisms in intimal hyperplasia

  2000cited by this paper
• MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.

  2000cited by this paper
• Association of mouse actin-binding protein 1 (mAbp1/SH3P7), an Src kinase target, with dynamic regions of the cortical actin cytoskeleton in response to Rac1 activation.

  2000cited by this paper
• MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation.

  2000cited by this paper
• [Vascular remodeling].

  2000cited by this paper
• MEKK1 interacts with alpha-actinin and localizes to stress fibers and focal adhesions.

  1999cited by this paper
• Primary mesenchymal cells isolated from SPARC-null mice exhibit altered morphology and rates of proliferation.

  1999cited by this paper
• MEK Kinase 1 (MEKK1) Transduces c-Jun NH2-terminal Kinase Activation in Response to Changes in the Microtubule Cytoskeleton*

  1999cited by this paper
• MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes.

  1999cited by this paper
• Deconstructing (and reconstructing) cell migration

  1998cited by this paper
• Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption.

  1998cited by this paper
• Remodeling with neointima formation in the mouse carotid artery after cessation of blood flow.

  1997cited by this paper
• Migration of vascular smooth muscle cells is enhanced in cultures derived from spontaneously hypertensive rat

  1997cited by this paper
• Urokinase but not tissue plasminogen activator mediates arterial neointima formation in mice.

  1997cited by this paper
• Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation

  1997cited by this paper
• Migration of arterial wall cells. Expression of plasminogen activators and inhibitors in injured rat arteries.

  1996cited by this paper

• Alisol A ameliorates vascular cognitive impairment via AMPK/NAMPT/SIRT1-mediated regulation of cholesterol and autophagy

  2025influential citation
• Aralia armata (Wall.) Seem Improves Intimal Hyperplasia after Vascular Injury by Downregulating the Wnt3α/Dvl-1/β-Catenin Pathway

  2021cites this paper
• Sphingosine 1-phosphate activates the MAP3K1-JNK pathway to promote epithelial movement and morphogenesis

  2020cites this paper
• Mechanism of Sex Determination in Humans: Insights from Disorders of Sex Development

  2016cites this paper
• Ligation of the Mouse Common Carotid Artery

  2016cites this paper
• MAP3K1 function is essential for cytoarchitecture of the mouse organ of Corti and survival of auditory hair cells

  2015cites this paper
• DMM023077 1543..1553

  2015cites this paper
• Loss of MAP3K1 enhances proliferation and apoptosis during retinal development

  2011cites this paper
• The Molecular Regulation of MAP3K1 in Eyelid Development

  2011cites this paper
• Étude de la polyubiquitination en lysine 63 dans les effets proinflammatoires de l'angiotensine II in vitro

  2010cites this paper
• Bcl2 enhances c-Myc-mediated MMP-2 expression of vascular smooth muscle cells.

  2009cites this paper
• Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes

  2008cites this paper
• Role of mitogen-activated protein kinase kinase kinases in signal integration

  2007cites this paper
• In vivo functions of mitogen-activated protein kinases: conclusions from knock-in and knock-out mice

  2007cites this paper
• c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells.

  2007influential citation
• Urokinase-type plasminogen activator deficiency (uPA-KO) prevented carotid artery ligation-induced vascular remodeling in mice.

  2007cites this paper
• Preclinical models of vascular inflammation

  2006cites this paper
• Mouse models of neointimal hyperplasia: techniques and applications.

  2006cites this paper