The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane

Hidetaka Tanno,Teppei Yamaguchi,E. Goto,S. Ishido,M. Komada

Published 2012 in Molecular Biology of the Cell

ABSTRACT

Ankrd 13A, 13B, and 13D constitute a family of ubiquitin-interacting motif (UIM)-bearing cytoplasmic proteins. They are anchored to the plasma membrane, where they recognize the Lys63-linked polyubiquitin chains tagged to ligand-activated EGF receptor and regulate the endocytosis of EGF receptor from the cell surface in mammalian cells.

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