An extracellular source of heme can induce a significant heme oxygenase mediated relaxation in the rat aorta.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Canadian Journal of Physiology and Pharmacology

• Publication date

  2002-08-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1139/Y02-086PMID 12269785
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The case of CO signaling: why the jury is still out.

  2001cited by this paper
• Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines.

  2001cited by this paper
• Influence of heme oxygenase inhibitors on the basal tissue enzymatic activity and smooth muscle relaxation of internal anal sphincter.

  2000cited by this paper
• Regulation and role of heme oxygenase in oxidative injury.

  2000cited by this paper
• Potentiation of carbon monoxide-induced relaxation of rat aorta by YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole].

  2000cited by this paper
• Selective inhibition of heme oxygenase, without inhibition of nitric oxide synthase or soluble guanylyl cyclase, by metalloporphyrins at low concentrations.

  1999cited by this paper
• Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice.

  1999cited by this paper
• Carbon monoxide and cerebral microvascular tone in newborn pigs.

  1999cited by this paper
• Carbon monoxide and cerebral microvascular tone in newborn pigs.

  1999cited by this paper
• Effect of heme oxygenase inhibitors on soluble guanylyl cyclase activity.

  1998cited by this paper
• Carbon monoxide as a regulator of bile canalicular contractility in cultured rat hepatocytes

  1998cited by this paper
• Carbon monoxide‐induced vasorelaxation and the underlying mechanisms

  1997cited by this paper
• Role of carbon monoxide in heme-induced vasodilation.

  1997cited by this paper
• Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide.

  1997cited by this paper
• The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ) inhibits relaxation of rabbit aortic rings induced by carbon monoxide, nitric oxide, and glyceryl trinitrate.

  1997cited by this paper
• The heme oxygenase system: a regulator of second messenger gases.

  1997cited by this paper
• Heme oxygenase substrates acutely lower blood pressure in hypertensive rats.

  1996cited by this paper
• Characterization of porphyrin heme oxygenase inhibitors.

  1996cited by this paper
• Carbon monoxide: a putative neural messenger.

  1993cited by this paper
• Endothelium-dependent and -independent vasodilation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light.

  1991cited by this paper
• Does carbon monoxide have a physiological function?

  1991cited by this paper
• Study on the mechanism of carbon monoxide induced endothelium-independent relaxation in porcine coronary artery and vein.

  1990cited by this paper
• Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase.

  1987cited by this paper
• MICROSOMAL HEME OXYGENASE

  1981cited by this paper
• Microsomal heme oxygenase. Characterization of the enzyme.

  1969cited by this paper

• Heme reduces corpus cavernosum smooth muscle contraction via the HO-CO-sGC-cGMP pathway: implications for priapism in sickle cell disease.

  2025cites this paper
• Targeting heme in sickle cell disease: new perspectives on priapism treatment

  2024cites this paper
• Heme‐induced corpus cavernosum relaxation and its implications for priapism in sickle cell disease: a mechanistic insight

  2024cites this paper
• Mitochondrial mechanisms by which gasotransmitters (H2S, NO and CO) protect cardiovascular system against hypoxia.

  2021cites this paper
• Therapeutic Aspects of Carbon Monoxide in Cardiovascular Disease

  2018cites this paper
• messengers in cerebrovascular circulation Carbon monoxide and hydrogen sulfide: gaseous

  2015cites this paper
• Investigating the role of heme oxygenase and oxidative stress in oesophagogastric cancer

  2013cites this paper
• Carbon monoxide as an endogenous vascular modulator.

  2011cites this paper
• The heme oxygenase – carbon monoxide system: regulation and role in stress response and organ failure

  2008cites this paper
• Heme oxygenase-1 induction depletes heme and attenuates pulmonary artery relaxation and guanylate cyclase activation by nitric oxide.

  2008cites this paper
• Protoporphyrin IX Generation from ä‐Aminolevulinic Acid Elicits Pulmonary Artery Relaxation and Soluble Guanylate Cyclase Activation

  2006cites this paper
• Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation.

  2006cites this paper
• The source of heme for vascular heme oxygenase I: heme uptake in rat aorta.

  2004cites this paper