Pentyl‐4‐yn‐valproic acid enhances both spatial and avoidance learning and attenuates age‐related NCAM‐mediated neuroplastic decline within the rat medial temporal lobe

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Neurochemistry

• Publication date

  2001-08-15

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1046/j.1471-4159.2001.00411.xPMID 11520891
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000influential reference
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  1998influential reference
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