Aryl-phosphonate lanthanide complexes and their fluorinated derivatives: investigation of their unusual relaxometric behavior and potential application as dual frequency 1H/19F MRI probes.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Chemistry

• Publication date

  2013-08-26

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/chem.201300763PMID 23868470
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Lanthanide Complexes as Paramagnetic Probes for 19F Magnetic Resonance

  2012cited by this paper
• The Solution Structure and Dynamics of MRI Probes Based on Lanthanide(III) DOTA as Investigated by DFT and NMR Spectroscopy

  2012cited by this paper
• Dissociation kinetics of open-chain and macrocyclic gadolinium(III)-aminopolycarboxylate complexes related to magnetic resonance imaging: catalytic effect of endogenous ligands.

  2012cited by this paper
• Relaxivity Enhancement in Macromolecular and Nanosized GdIII‐Based MRI Contrast Agents

  2012cited by this paper
• Strategies to enhance signal intensity with paramagnetic fluorine-labelled lanthanide complexes as probes for 19F magnetic resonance.

  2011cited by this paper
• An aryl-phosphonate appended macrocyclic platform for lanthanide based bimodal imaging agents.

  2011cited by this paper
• Influence of calcium-induced aggregation on the sensitivity of aminobis(methylenephosphonate)-containing potential MRI contrast agents.

  2011cited by this paper
• 19F MRI detection of β-galactosidase activity for imaging of gene expression

  2011cited by this paper
• 19F‐lanthanide complexes with increased sensitivity for 19F‐MRI: Optimization of the MR acquisition

  2011cited by this paper
• Synthesis and Evaluation of Water‐Soluble Fluorinated Dendritic Block‐Copolymer Nanoparticles as a 19F‐MRI Contrast Agent

  2010cited by this paper
• An open-source software tool for the generation of relaxation time maps in magnetic resonance imaging

  2010cited by this paper
• Functional hyperbranched polymers: toward targeted in vivo 19F magnetic resonance imaging using designed macromolecules.

  2010cited by this paper
• Equilibrium Studies on the Gd3+, Cu2+ and Zn2+ Complexes of BOPTA, DTPA and DTPA‐BMA Ligands: Kinetics of Metal‐Exchange Reactions of [Gd(BOPTA)]2–

  2010cited by this paper
• (19)F MRI for quantitative in vivo cell tracking.

  2010cited by this paper
• Poly-beta-cyclodextrin based platform for pH mapping via a ratiometric 19F/1H MRI method.

  2009cited by this paper
• Changing the local coordination environment in mono- and bi- nuclear lanthanide complexes through "click" chemistry.

  2009cited by this paper
• Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-based Propylphosphonates

  2009cited by this paper
• MRI‐Kontrastmittel mit hoher Relaxivität: Komplexchemie im Dienste medizinischer Bildgebung

  2008cited by this paper
• Paramagnetic relaxation-based 19f MRI probe to detect protease activity.

  2008cited by this paper
• High relaxivity gadolinium hydroxypyridonate-viral capsid conjugates: nanosized MRI contrast agents.

  2008cited by this paper
• Feasibility studies in spheronization and scale-up of ibuprofen microparticulates using the rotor disk fluid-bed technology

  2008cited by this paper
• High-relaxivity MRI contrast agents: where coordination chemistry meets medical imaging.

  2008cited by this paper
• In vivo “hot spot” MR imaging of neural stem cells using fluorinated nanoparticles

  2008cited by this paper
• Molecular imaging in drug development

  2008cited by this paper
• Synthesis, potentiometric, kinetic, and NMR Studies of 1,4,7,10-tetraazacyclododecane-1,7-bis(acetic acid)-4,10-bis(methylenephosphonic acid) (DO2A2P) and its complexes with Ca(II), Cu(II), Zn(II) and lanthanide(III) ions.

  2008cited by this paper
• 19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons

  2007cited by this paper
• Thermodynamic study of lanthanide(III) complexes with bifunctional monophosphinic acid analogues of H4dota and comparative kinetic study of yttrium(III) complexes.

  2007cited by this paper
• Physicochemical and MRI characterization of Gd3+-loaded polyamidoamine and hyperbranched dendrimers

  2007cited by this paper
• Molecular and Cellular MR Imaging

  2007cited by this paper
• Gadolinium(III) complexes of mono- and diethyl esters of monophosphonic acid analogue of DOTA as potential MRI contrast agents: solution structures and relaxometric studies.

  2007cited by this paper
• Relaxometric and solution NMR structural studies on ditopic lanthanide(III) complexes of a phosphinate analogue of DOTA with a fast rate of water exchange.

  2006cited by this paper
• Study of thermodynamic and kinetic stability of transition metal and lanthanide complexes of DTPA analogues with a phosphorus acid pendant arm

  2006cited by this paper
• A starburst-shaped heterometallic compound incorporating six densely packed gd(3+) ions.

  2006cited by this paper
• Strategies for increasing the sensitivity of gadolinium based MRI contrast agents.

  2006cited by this paper
• A cationic lanthanide complex binds selectively to phosphorylated tyrosine sites, aiding NMR analysis of the phosphorylated insulin receptor peptide fragment.

  2006cited by this paper
• Unexpected aggregation of neutral, xylene-cored dinuclear GdIII chelates in aqueous solution.

  2006cited by this paper
• Relaxivity in paramagnetic systems: Theory and mechanisms

  2006cited by this paper
• Lanthanide(III) complexes of a mono(methylphosphonate) analogue of H4dota: the influence of protonation of the phosphonate moiety on the TSAP/SAP isomer ratio and the water exchange rate.

  2005cited by this paper
• In vivo imaging platform for tracking immunotherapeutic cells

  2005cited by this paper
• Lanthanide(III) complexes of DOTA-glycoconjugates: a potential new class of lectin-mediated medical imaging agents.

  2004cited by this paper
• Complexing mechanism of the lanthanide cations Eu3+, Gd3+, and Tb3+ with 1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (dota)-characterization of three successive complexing phases: study of the thermodynamic and structural properties of the complexes by potentiometry, luminescence

  2004cited by this paper
• Studies on the kinetic stabilities of the Gd(3+) complexes formed with the N-mono(methylamide), N'-mono(methylamide) and N,N"-bis(methylamide) derivatives of diethylenetriamine-N,N,N',N",N"-pentaacetic acid.

  2002cited by this paper
• The impact of rigidity and water exchange on the relaxivity of a dendritic MRI contrast agent.

  2002cited by this paper
• Being excited by lanthanide coordination complexes: aqua species, chirality, excited-state chemistry, and exchange dynamics.

  2002cited by this paper
• Long wavelength sensitizers for europium(III) luminescence based on acridone derivatives

  2002cited by this paper
• Comparisons of pKa and log P values of some carboxylic and phosphonic acids: Synthesis and measurement

  2001cited by this paper
• A stable, high relaxivity, diaqua gadolinium complex that suppresses anion and protein bindingElectronic supplementary information (ESI) available: pH dependence of europium emission spectra, stability screening details and relaxivity/pH plots for selected Gd complexes. See http://www.rsc.org/suppda

  2001cited by this paper
• Determination of paramagnetic lanthanide(III) concentrations from bulk magnetic susceptibility shifts in NMR spectra

  2001cited by this paper
• Second Coordination Sphere Water Molecules and Relaxivity of Gadolinium(III) Complexes: Implications for MRI Contrast Agents

  2000cited by this paper
• Magnetic resonance contrast enhancement of neovasculature with alpha(v)beta(3)-targeted nanoparticles.

  2000cited by this paper
• Thermodynamic and structural properties of Gd(III) complexes with polyamino-polycarboxylic ligands: basic compounds for the development of MRI contrast agents

  2000cited by this paper
• Correlation of Water Exchange Rate with Isomeric Composition in Diastereoisomeric Gadolinium Complexes of Tetra(carboxyethyl)dota and Related Macrocyclic Ligands

  2000cited by this paper
• Non-covalent conjugates between cationic polyamino acids and GdIII chelates: a route for seeking accumulation of MRI-contrast agents at tumor targeting sites.

  2000cited by this paper
• Magnetic resonance contrast enhancement of neovasculature with αvβ3‐targeted nanoparticles

  2000cited by this paper
• Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications.

  1999cited by this paper
• Diffusion Ordered Nuclear Magnetic Resonance Spectroscopy: Principles and Applications

  1999cited by this paper
• Non-radiative deactivation of the excited states of europium, terbium and ytterbium complexes by proximate energy-matched OH, NH and CH oscillators: an improved luminescence method for establishing solution hydration states

  1999cited by this paper
• NMR relaxometric studies of Gd(III) complexes with heptadentate macrocyclic ligands

  1998cited by this paper
• Lanthanide(III) chelates for NMR biomedical applications

  1998cited by this paper
• Conformational and Coordination Equilibria on DOTA Complexes of Lanthanide Metal Ions in Aqueous Solution Studied by (1)H-NMR Spectroscopy.

  1997cited by this paper
• Photosensitized Near Infrared Luminescence of Ytterbium(III) in Proteins and Complexes Occurs via an Internal Redox Process

  1997cited by this paper
• Lanthanide induced shifts and relaxation rate enhancements

  1996cited by this paper
• Structural and Dynamic Parameters Obtained from 17O NMR, EPR, and NMRD Studies of Monomeric and Dimeric Gd3+ Complexes of Interest in Magnetic Resonance Imaging: An Integrated and Theoretically Self-Consistent Approach1

  1996cited by this paper
• Extent of hydration of octadentate lanthanide complexes incorporating phosphinate donors: solution relaxometry and luminescence studies

  1996cited by this paper
• Kinetics of Complex Formation by Macrocyclic Polyaza Polycarboxylate Ligands: Detection and Characterization of an Intermediate in the Eu3+-dota System by Laser-Excited Luminescence

  1995cited by this paper
• Metal complexes with macrocyclic ligands. Part XXXVI†. Thermodynamic and kinetic studies of bivalent and trivalent metal ions with 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid

  1994cited by this paper
• Effect of Ligand Basicity on the Formation and Dissociation Equilibria and Kinetics of Gd3+ Complexes of Macrocyclic Polyamino Carboxylates

  1994cited by this paper
• Kinetics of Formation and Dissociation of Lanthanide(III)-DOTA Complexes

  1994cited by this paper
• Oxygen-17 NMR study of water exchange on gadolinium polyaminopolyacetates [Gd(DTPA)(H2O)]2- and [Gd(DOTA)(H2O)]- related to NMR imaging

  1993cited by this paper
• Complexes of lanthanoid salts with macrocyclic ligands. 41. Photophysical properties of lanthanide dinuclear complexes with p-tert-butylcalix[8]arene

  1993cited by this paper
• NMR study of solution structures and dynamics of lanthanide(III) complexes of DOTA

  1992cited by this paper
• Field-cycling relaxometry of protein solutions and tissue: Implications for MRI

  1990cited by this paper
• Thermodynamic study of lanthanide complexes of 1,4,7-triazacyclononane-N,N',N"-triacetic acid and 1,4,7,10-tetraazacyclododecane-N,N',N",N'''-tetraacetic acid

  1987cited by this paper
• Computational methods for the determination of formation constants

  1985cited by this paper
• Metal complexes of cyclic tetra-azatetra-acetic acids.

  1982cited by this paper
• Nuclear magnetic resonance and potentiometric studies of the protonation scheme of two tetraaza tetraacetic macrocycles

  1981cited by this paper
• Phase and intensity anomalies in fourier transform NMR

  1971cited by this paper
• A study of some problems in determining the stoicheiometric proton dissociation constants of complexes by potentiometric titrations using a glass electrode

  1967cited by this paper
• NMR‐Relaxation Mechanisms of O17 in Aqueous Solutions of Paramagnetic Cations and the Lifetime of Water Molecules in the First Coordination Sphere

  1962cited by this paper
• Proton Relaxation Times in Paramagnetic Solutions. Effects of Electron Spin Relaxation

  1961cited by this paper

• Epidermal Growth Factor Receptor (EGFR)-Targeting Peptides and Their Applications in Tumor Imaging Probe Construction: Current Advances and Future Perspectives

  2025cites this paper
• Organophosphates as Versatile Substrates in Organic Synthesis

  2024cites this paper
• Transition metal complexes of the (2,2,2-trifluoroethyl)phosphinate NOTA analogue as potential contrast agents for 19F magnetic resonance imaging.

  2024cites this paper
• Design of Highly Fluorinated Peptides for Cell-based 19F NMR.

  2023cites this paper
• Exploiting the Fluxionality of Lanthanide Complexes in the Design of Paramagnetic Fluorine Probes.

  2022cites this paper
• Towards Photoswitchable Contrast Agents for Absolute 3D Temperature MR Imaging

  2021cites this paper
• 19F MRI Probes for Multimodal Imaging.

  2021cites this paper
• Efficient temperature-feedback liposome for 19F MRI signal enhancement.

  2020cites this paper
• Unexpected Trends in the Stability and Dissociation Kinetics of Lanthanide(III) Complexes with Cyclen-Based Ligands across the Lanthanide Series.

  2020cites this paper
• Gadolinium(III)-Based Dual 1 H/19 F Magnetic Resonance Imaging Probes.

  2019cites this paper
• Applications of H-phosphonates for C element bond formation

  2018cites this paper
• 17O NMR as a Tool in Discrete Metal Oxide Cluster Chemistry

  2018cites this paper
• Editorial: The Chemistry of Imaging Probes

  2018cites this paper
• 17O NMR as a Tool in Discrete Metal Oxide Cluster Chemistry

  2018cites this paper
• Fluorinated Paramagnetic Complexes: Sensitive and Responsive Probes for Magnetic Resonance Spectroscopy and Imaging

  2018influential citation
• Coordination Properties of GdDO3A-Based Model Compounds of Bioresponsive MRI Contrast Agents.

  2018cites this paper
• Fe- and Ln-DOTAm-F12 Are Effective Paramagnetic Fluorine Contrast Agents for MRI in Water and Blood.

  2017cites this paper
• A macrocyclic 19F-MR based probe for Mn2 + sensing

  2017cites this paper
• Ligation driven (19)F relaxation enhancement in self-assembled Ln(III) complexes.

  2015cites this paper
• 17O NMR: A “Rare and Sensitive” Probe of Molecular Interactions and Dynamics

  2015cites this paper
• Palladium‐Catalyzed CP Cross‐Coupling of Arylhydrazines with H‐Phosphonates via CN Bond Cleavage

  2014cites this paper
• New calcium-selective smart contrast agents for magnetic resonance imaging.

  2013cites this paper