Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Arzneimittel-Forschung

• Publication date

  1994-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  PMID 7848348
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Repeated administration of selective adenosine A1 and A2 receptor agonists in the spontaneously hypertensive rat: tolerance develops to A1-mediated hemodynamic effects.

  1994cited by this paper
• In vivo and ex vivo effects of adenosine A1 and A2 receptor agonists on platelet aggregation in the rabbit.

  1994cited by this paper
• A1 receptor mediated myocardial infarct size reduction by endogenous adenosine is exerted primarily during ischaemia.

  1994cited by this paper
• Nomenclature and classification of purinoceptors.

  1994cited by this paper
• Effects of selective A1 and A2 adenosine receptor agonists on cardiovascular tissues

  1993cited by this paper
• Mechanisms of action and therapeutic potential of adenosine and its analogues in the treatment of cardiac arrhythmias.

  1993cited by this paper
• Adenosine receptor subtypes.

  1993cited by this paper
• Intravenous Pretreatment With A1‐Selective Adenosine Analogues Protects the Heart Against Infarction

  1992cited by this paper
• Effects of adenosine derivatives on human and rabbit platelet aggregation

  1992cited by this paper
• Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.

  1992cited by this paper
• Effects of selected beta-adrenergic blocking agents on sleep stages in spontaneously hypertensive rats.

  1991cited by this paper
• Protection Against Infarction Afforded by Preconditioning is Mediated by A1 Adenosine Receptors in Rabbit Heart

  1991cited by this paper
• Cardiac Electrophysiology of Adenosine: Basic and Clinical Concepts

  1991cited by this paper
• Radioisotopic model for investigating thromboembolism in the rabbit.

  1990cited by this paper
• Assessment of ischemic injury and protective interventions: the Langendorff versus the working rat heart preparation.

  1990cited by this paper
• [3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain.

  1989cited by this paper
• 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors

  1988cited by this paper
• Antihypertensive activity of a new ACE-inhibitor, SCH 33844, during repeated administration in spontaneously hypertensive rats.

  1987cited by this paper
• Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.

  1986cited by this paper
• N6-cycloalkyladenosines. Potent, A1-selective adenosine agonists.

  1985cited by this paper
• Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine.

  1980cited by this paper
• Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.

  1973cited by this paper

• The Role of Adenosine A1 and A2a Receptors in Cerebral Blood Vessel Reactivity of Sprague Dawley Rats Exposed to Hyperbaric Oxygenation

  2025cites this paper
• Probing the synaptic target of a new putative antiepileptic drug: modulation of the excitatory transmission in the hippocampus

  2016cites this paper
• Effects of nucleosides on glia - neuron interactions open up new vistas in the development of more effective antiepileptic drugs.

  2015cites this paper
• The antiepileptic potential of nucleosides.

  2014cites this paper
• An Fc Domain Protein–Small Molecule Conjugate as an Enhanced Immunomodulator

  2014cites this paper
• Adenosine A2A receptor as a drug discovery target.

  2014cites this paper
• Disruption of Adenosine Homeostasis in Epilepsy and Therapeutic Adenosine Augmentation

  2013cites this paper
• Development of new chromatographic tools based on A2A adenosine receptor subtype for ligand characterization and screening by FAC-MS

  2012cites this paper
• Role of adenosine in Pre and Post conditioning: A Good Arsenal of Heart

  2012cites this paper
• Wirkungen einer chronischen Vorbehandlung mit dem selektiven Adenosin-A1-Rezeptor- Agonisten 2-Chloro-N6-Cyclopentyladenosin (CCPA) auf die Nierenfunktion der Ratte

  2012cites this paper
• Adenosine kinase as a target for therapeutic antisense strategies in epilepsy

  2011cites this paper
• Engineered adenosine-releasing cells for epilepsy therapy: Human mesenchymal stem cells and human embryonic stem cells

  2009cites this paper
• Adenosine-A1 Receptors Activation Restores the Suppressed Cardioprotective Effects of Ischemic Preconditioning in Hyperhomocysteinemic Rat Hearts

  2009cites this paper
• Adenosine augmentation therapies (AATs) for epilepsy: prospect of cell and gene therapies.

  2009cites this paper
• Therapeutic epilepsy research: from pharmacological rationale to focal adenosine augmentation.

  2009cites this paper
• The adenosine kinase hypothesis of epileptogenesis.

  2008cites this paper
• Adenosine as a modulator of brain activity.

  2007cites this paper
• Modulatory role of adenosine and its receptors in epilepsy: possible therapeutic approaches.

  2006cites this paper
• Targeting the Brain: Focal Delivery of Natural Anticonvulsant Molecules

  2005cites this paper
• Adenosine and Epilepsy: From Therapeutic Rationale to New Therapeutic Strategies

  2005cites this paper
• Pharmacology and therapeutic applications of A1 adenosine receptor ligands.

  2003cites this paper
• Seizure Suppression by Adenosine A1 Receptor Activation in a Mouse Model of Pharmacoresistant Epilepsy

  2003cites this paper
• 2-Chloro-N(6)-cyclopentyladenosine, adenosine A(1) receptor agonist, antagonizes the adenosine A(3) receptor.

  2002cites this paper
• Purine nucleosides bearing 1-alkynyl chains as adenosine receptor agonists.

  2002cites this paper
• Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues.

  2002cites this paper
• Seizure suppression by adenosine A(2A) receptor activation in a rat model of audiogenic brainstem epilepsy.

  2002cites this paper
• 2-Chloro-N6-cyclopentyladenosine, adenosine A1 receptor agonist, antagonizes the adenosine A3 receptor

  2002cites this paper
• Role of endothelium in adenosine receptor‐mediated vasorelaxation in hypertensive rats

  2001cites this paper
• Relaxation of rat aorta by adenosine in diabetes with and without hypertension: role of endothelium.

  2001cites this paper
• Adenosine receptor ligands-recent developments part I. Agonists.

  2000cites this paper
• Effects of adenosine receptor agonists on efferent renal nerve activity in anesthetized rats.

  2000cites this paper
• Role of A2A receptor in the modulation of myocardial reperfusion damage.

  1999cites this paper
• Cardiovascular pharmacology of the A2A adenosine receptor antagonist, SCH 58261, in the rat.

  1998cites this paper
• Adenosine, KATP Channel, and Cardioprotection in the Intact Heart

  1998cites this paper
• Characterization of potent ligands at human recombinant adenosine receptors

  1998cites this paper
• Mechanism and pressor relevance of the short-term cardiovascular and renin excitatory actions of the selective A2A-adenosine receptor agonists.

  1997cites this paper
• Adenosine A2A Receptors and Neuroprotection

  1997cites this paper
• Repeated treatment with adenosine A1 receptor agonist and antagonist modifies the anticonvulsant properties of CPPene.

  1996cites this paper
• Effects of repeated administration of selective adenosine A1 and A2A receptor agonists on pentylenetetrazole-induced convulsions in the rat.

  1995cites this paper
• Effects of pH on responses to adenosine, CGS 21680, carbachol and nitroprusside in the isolated perfused superior mesenteric arterial bed of the rat

  1995cites this paper
• Modeling hemodynamic profiles by telemetry in the rat. A study with A1 and A2a adenosine agonists.

  1995cites this paper
• Effects ofpH on responsestoadenosine, CGS21680, carbachol andnitroprusside intheisolated perfused superior mesenteric arterial bedoftherat

  1995cites this paper