Isoproterenol excretion and metabolism in the isolated perfused rat kidney.

[3H]isoproterenol excretion and metabolism were studied in the isolated perfused rat kidney using a one-pass, non-recirculating perfusion system with constant infusion rates of [3H]isoproterenol. The [3H]isoproterenol (U/P) to inulin (U/P) ratio was approximately 15 indicating extensive tubular secretion. A major renal metabolite, 3-O-methylisoproterenol, appeared in the urine and renal vein perfusate and also accumulated in the renal tissue. The fractional excretion of isoproterenol decreased with time while fractional excretion of p-aminohippurate remained stable. The observed decreasing urinary clearance and percent extraction of isoproterenol with time may be due to the progressive intrarenal accumulation of 3-O-methylisoproterenol.

• Publication year

  1979

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  1979-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0022-3565(25)31747-7PMID 458636
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanism of isoproterenol-induced desensitization of tracheal smooth muscle.

  1977cited by this paper
• Effect of catecholamines on tubular function in the isolated perfused rat kidney.

  1977cited by this paper
• Mechanism of renal clearance of isoproterenol.

  1973cited by this paper
• Glucose transport by the isolated perfused rat kidney.

  1972cited by this paper
• Mechanism of antidiuretic effect of beta adrenergic stimulation.

  1972cited by this paper
• Metabolism of isoprenaline in dog and man

  1972cited by this paper
• The inactivation of noradrenaline and isoprenaline in dogs

  1970cited by this paper
• Isoprenaline resistance and the use of pressurised aerosols in asthma.

  1968cited by this paper
• URINARY METABOLITES OF EPINEPHRINE AND NOREPINEPHRINE IN THE CHICKEN.

  1965cited by this paper
• THE FATE OF 3H-ISO-PROTERENOL IN THE RAT.

  1964cited by this paper
• Renal tubular excretion of dl-epine-phrine-2-C14 in the chicken.

  1962cited by this paper
• A new method for the determination of inulin in plasma and urine.

  1956cited by this paper
• Measurement of renal blood flow.

  1948cited by this paper

• Effects of Intrauterine Isoproterenol Administration on Ovarian Follicular Development in Cows

  2025cites this paper
• Bioactive benzoxazinoids in rye bread are absorbed and metabolized in pigs.

  2012cites this paper
• Molecular Cloning, Expression, purification and Characterization of the Zebrafish Catechol-O-methyltransferases

  2011cites this paper
• A Thesis

  2011cites this paper
• Drug dosing in chronic kidney disease.

  2005cites this paper
• Renal handling of drugs and xenobiotics

  2003cites this paper
• Renal drug metabolism.

  1998cites this paper
• Pharmacologie des sympathomimétiques: indications thérapeutiques en réanimation cardiovasculaire

  1997cites this paper
• Drug biotransformation by the kidney: how important is it, and how much do we really know?

  1991cites this paper
• Flow-dependent extraction of 1-naphthol by the rat isolated perfused kidney

  1991cites this paper
• Renal Excretion and Tubular Transport of Organic Anions and Cations

  1991cites this paper
• Renal handling of enalapril and enalaprilat: studies in the isolated red blood cell-perfused rat kidney.

  1989cites this paper
• Nephrotoxicity: a rational approach to target cell injury in vitro in the kidney.

  1988cites this paper
• Conjugative clearance of 1-naphthol and disposition of its glucuronide and sulfate conjugates in the isolated perfused rat kidney.

  1988cites this paper
• Renal excretion of drugs and other xenobiotics.

  1987cites this paper
• Renal Slices and Perfusion

  1987cites this paper
• Renal disease and drug metabolism: an overview.

  1986cites this paper
• Relationship between energy requirements for Na+ reabsorption and other renal functions.

  1986cites this paper
• Chemically induced renal papillary necrosis and upper urothelial carcinoma. Part 1.

  1985cites this paper
• Chemically induced renal papillary necrosis and upper urothelial carcinoma. Part 2.

  1985cites this paper
• The isolated perfused kidney as a pharmacological tool

  1983cites this paper
• Use of the isolated perfused kidney as a tool in drug disposition studies.

  1983cites this paper
• Chapter 13 – Conjugation of Phenols

  1982cites this paper
• Isolated perfused rat kidney.

  1981cites this paper
• Renal Transport of Drugs

  1981cites this paper
• Chapter 29. Drug Metabolism

  1981cites this paper
• Renal tubule transport of organic cations.

  1981cites this paper
• Prednisolone metabolism and excretion in the isolated perfused rat kidney.

  1981cites this paper