Hydrogen Sulfide Attenuates Opioid Dependence by Suppression of Adenylate Cyclase/cAMP Pathway

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Antioxidants and Redox Signaling

• Publication date

  2014-01-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1089/ars.2012.5119PMID 23682813PMCID PMC3880902
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanism of action of hydrogen sulfide on cyclic AMP formation in rat retinal pigment epithelial cells.

  2012cited by this paper
• Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is H2S a novel cytoprotective mediator in the inflamed joint?

  2012cited by this paper
• The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo

  2011cited by this paper
• Hydrogen Sulfide: Neurophysiology and Neuropathology

  2011cited by this paper
• Protective effect of hydrogen sulphide against 6‐OHDA‐induced cell injury in SH‐SY5Y cells involves PKC/PI3K/Akt pathway

  2010cited by this paper
• Naloxone-precipitated withdrawal enhances ERK phosphorylation in prefrontal association cortex and accumbens nucleus of morphine-dependent mice.

  2010cited by this paper
• Characterization of vasopressin-responsive collecting duct adenylyl cyclases in the mouse.

  2010cited by this paper
• Hydrogen sulfide inhibits plasma renin activity.

  2010cited by this paper
• Morphine-Induced Changes of Adenylate and Guanylate Cyclase in Locus Ceruleus, Periaqueductal Gray, and Substantia Nigra in Rats

  2009cited by this paper
• Capturing adenylyl cyclases as potential drug targets

  2009cited by this paper
• Chronic morphine administration induces over-expression of aldolase C with reduction of CREB phosphorylation in the mouse hippocampus.

  2009cited by this paper
• Vasoconstrictive effect of hydrogen sulfide involves downregulation of cAMP in vascular smooth muscle cells.

  2008cited by this paper
• Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies.

  2008cited by this paper
• Negative regulation of beta-adrenergic function by hydrogen sulphide in the rat hearts.

  2008cited by this paper
• Characterization of a Novel, Water-Soluble Hydrogen Sulfide–Releasing Molecule (GYY4137): New Insights Into the Biology of Hydrogen Sulfide

  2008cited by this paper
• Role of cAMP Response Element-Binding Protein in the Rat Locus Ceruleus: Regulation of Neuronal Activity and Opiate Withdrawal Behaviors

  2006cited by this paper
• Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action.

  2006cited by this paper
• Cystathionine beta-synthase is enriched in the brains of Down's patients.

  2005cited by this paper
• Interferon-γ Down-regulates Adenosine 2b Receptor-mediated Signaling and Short Circuit Current in the Intestinal Epithelia by Inhibiting the Expression of Adenylate Cyclase*

  2005cited by this paper
• Cystathionine β‐synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS

  2005cited by this paper
• Cystathionine β-synthase is enriched in the brains of Down’s patients

  2005cited by this paper
• Naloxone-precipitated withdrawal jumping in 11 inbred mouse strains: evidence for common genetic mechanisms in acute and chronic morphine physical dependence.

  2002cited by this paper
• Characterization of the mouse adenylyl cyclase type VIII gene promoter: regulation by cAMP and CREB

  2002cited by this paper
• Regional and Cellular Mapping of cAMP Response Element-Mediated Transcription during Naltrexone-Precipitated Morphine Withdrawal

  2002cited by this paper
• Cellular and synaptic adaptations mediating opioid dependence.

  2001cited by this paper
• Molecular biological approaches to unravel adenylyl cyclase signaling and function.

  2001cited by this paper
• Protein kinases modulate the cellular adaptations associated with opioid tolerance and dependence.

  2001cited by this paper
• Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor.

  2000cited by this paper
• Extracellular-signal-regulated kinase signalling in neurons.

  1999cited by this paper
• Opioid withdrawal activates MAP kinase in locus coeruleus neurons in morphine‐dependent rats in vivo

  1998cited by this paper
• Chronic morphine augments adenylyl cyclase phosphorylation: relevance to altered signaling during tolerance/dependence.

  1998cited by this paper
• Chronic morphine augments G(beta)(gamma)/Gs(alpha) stimulation of adenylyl cyclase: relevance to opioid tolerance.

  1998cited by this paper
• Molecular and cellular basis of addiction.

  1997influential reference
• Opposite Modulation of Opiate Withdrawal Behaviors on Microinfusion of a Protein Kinase A Inhibitor Versus Activator into the Locus Coeruleus or Periaqueductal Gray

  1997cited by this paper
• CREB (cAMP Response Element-Binding Protein) in the Locus Coeruleus: Biochemical, Physiological, and Behavioral Evidence for a Role in Opiate Dependence

  1997influential reference
• Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity.

  1996cited by this paper
• Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment.

  1995cited by this paper
• Extracellular signal-regulated protein kinases (ERKs) and ERK kinase (MEK) in brain: regional distribution and regulation by chronic morphine

  1995cited by this paper
• Activation of Type II Adenylyl Cyclase by the Cloned μ‐Opioid Receptor: Coupling to Multiple G Proteins

  1995cited by this paper
• Chronic morphine administration causes region-specific increase of brain type VIII adenylyl cyclase mRNA.

  1994cited by this paper
• Cloning and expression of an adenylyl cyclase localized to the corpus striatum

  1993cited by this paper
• Destruction of the locus coeruleus decreases physical signs of opiate withdrawal.

  1993cited by this paper
• Regulation of Cyclic AMP Response Element‐Binding Protein (CREB) Phosphorylation by Acute and Chronic Morphine in the Rat Locus Coeruleus

  1992cited by this paper
• A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function.

  1991cited by this paper
• Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain.

  1991cited by this paper
• Regulation of Cyclic AMP by the μ‐Opioid Receptor in Human Neuroblastoma SH‐SY5Y Cells

  1990cited by this paper
• Mechanisms of cellular adaptive sensitivity changes: applications to opioid tolerance and dependence.

  1989cited by this paper
• Chronic morphine treatment increases cyclic AMP-dependent protein kinase activity in the rat locus coeruleus.

  1988influential reference
• Neuroanatomical patterns of the mu, delta, and kappa opioid receptors of rat brain as determined by quantitative in vitro autoradiography.

  1987cited by this paper
• Opiate-dependent modulation of adenylate cyclase.

  1977cited by this paper

• Gasotransmitters (NO, H2S, CO) as Contributors to the Nociceptive Process in the Trigeminovascular System

  2025cites this paper
• Genetic insights into the therapeutic potential of hydrogen sulfide.

  2025cites this paper
• Hydrogen Sulfide Deficiency Contributes to Tubular Damage and Calcium Oxalate Crystal Formation in Hyperoxaluria Nephropathy: Role of Osteopontin and Tamm–Horsfall Protein

  2025cites this paper
• The cystathionine-γ-lyase inhibitor DL-propargylglycine augments the ability of L-cysteine ethyl ester to overcome the adverse effects of morphine on breathing.

  2025cites this paper
• Novel neurotherapeutic targets for substance use disorders: Neuroplasticity, neuroinflammation, gasotransmitters and non-canonical organ systems

  2025cites this paper
• H2S inhibits LiCl/pilocarpine-induced seizures and promotes neuroprotection by regulating TRPV2 expression via the AC3/cAMP/PKA pathway.

  2024cites this paper
• Synaptic Structure and Transcriptomic Profiling of Reward and Sensory Brain Areas in Male Mice of Fentanyl Addiction

  2024cites this paper
• Selective monitoring and treatment of neuroblastoma cells with hydrogen sulfide activatable phototheranostic agent

  2023cites this paper
• A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?

  2022cites this paper
• Naturally occurring glucosinolates and isothiocyanates as a weapon against chronic pain: potentials and limits

  2022cites this paper
• Naturally occurring glucosinolates and isothiocyanates as a weapon against chronic pain: potentials and limits

  2022cites this paper
• Opioid receptors signaling network

  2021cites this paper
• Synthesis of the Mechanisms of Opioid Tolerance: Do We Still Say NO?

  2021cites this paper
• Vitamin D and Its Potential Interplay With Pain Signaling Pathways

  2020cites this paper
• The Role of Hydrogen Sulfide in the Development of Tolerance and Dependence to Morphine in Mice

  2020cites this paper
• The gasotransmitter hydrogen sulfide inhibits transepithelial anion secretion of pregnant mouse endometrial epithelium.

  2019cites this paper
• Potential role of the ecto‐5′‐nucleotidase in morphine‐induced uridine release and neurobehavioral changes

  2018cites this paper
• Age-Dependent, Subunit Specific Action of Hydrogen Sulfide on GluN1/2A and GluN1/2B NMDA Receptors

  2017cites this paper
• H2S is a key antisecretory molecule against cholera toxin-induced diarrhoea in mice: Evidence for non-involvement of the AC/cAMP/PKA pathway and AMPK.

  2017cites this paper
• The role of hydrogen sulfide in cyclic nucleotide signaling

  2017cites this paper
• Hydrogen sulfide stimulates CFTR in Xenopus oocytes by activation of the cAMP/PKA signalling axis

  2017cites this paper
• Hydrogen sulfide attenuates brain edema in early brain injury after subarachnoid hemorrhage in rats: Possible involvement of MMP-9 induced blood-brain barrier disruption and AQP4 expression.

  2016cites this paper
• Pharmacological modulation of protein kinases as a new approach to treat addiction to cocaine and opiates.

  2016cites this paper
• Endogenous opiates and behavior: 2014.

  2016cites this paper
• Opioid Dependence and the Adenylyl Cyclase/cAMP Signaling

  2016cites this paper
• stimulated lung liquid clearance by inhibiting ENaC

  2015cites this paper
• Erythrocytic hydrogen sulfide production is increased in children with vasovagal syncope.

  2015cites this paper
• Hydrogen sulfide in pharmacology and medicine — An update

  2015cites this paper
• Brain, Learning, and Memory: Role of H2S in Neurodegenerative Diseases.

  2015cites this paper
• Hydrogen sulfide decreases β-adrenergic agonist-stimulated lung liquid clearance by inhibiting ENaC-mediated transepithelial sodium absorption.

  2015cites this paper
• Influence of morphine on medial prefrontal cortex alpha2 adrenergic system in passive avoidance learning in rats.

  2015cites this paper
• Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

  2015influential citation
• Therapies in early development for the treatment of opiate addiction

  2015cites this paper
• Hydrogen sulfide: metabolism, biological and medical role.

  2014cites this paper
• Kir3 channel signaling complexes: focus on opioid receptor signaling

  2014cites this paper
• Hydrogen sulfide inhibits Na+ uptake in larval zebrafish, Danio rerio

  2014cites this paper
• Hydrogen Sulfide: A New Tool to Design and Develop Drugs

  2014cites this paper
• Hydrogen sulfide: a neuromodulator and neuroprotectant in the central nervous system.

  2014cites this paper
• Hydrogen Sulfide Inhibits A2A Adenosine Receptor Agonist Induced β-Amyloid Production in SH-SY5Y Neuroblastoma Cells via a cAMP Dependent Pathway

  2014cites this paper
• Hydrogen sulfide inhibits opioid withdrawal-induced pain sensitization in rats by down-regulation of spinal calcitonin gene-related peptide expression in the spine.

  2014cites this paper
• Regionally selective activation of ERK and JNK in morphine paradoxical hyperalgesia: a step toward improving opioid pain therapy.

  2014cites this paper
• Hydrogen Sulfide: Physiological and Pathophysiological Functions

  2013cites this paper
• Sodium/calcium exchanger is upregulated by sulfide signaling, forms complex with the β1 and β3 but not β2 adrenergic receptors, and induces apoptosis

  2013cites this paper