RGS protein specificity towards Gq- and Gi/o-mediated ERK 1/2 and Akt activation, in vitro.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of biochemistry and molecular biology

• Publication date

  2007-11-30

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.5483/BMBREP.2007.40.6.899PMID 18047785
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of cardiomyocyte signaling by RGS proteins: differential selectivity towards G proteins and susceptibility to regulation.

  2006cited by this paper
• Selective Loss of Fine Tuning of Gq/11 Signaling by RGS2 Protein Exacerbates Cardiomyocyte Hypertrophy*

  2006cited by this paper
• Gα12/13- and Reactive Oxygen Species-dependent Activation of c-Jun NH2-terminal Kinase and p38 Mitogen-activated Protein Kinase by Angiotensin Receptor Stimulation in Rat Neonatal Cardiomyocytes*

  2005cited by this paper
• Regulation of the extracellular signal-regulated kinase pathway in adult myocardium: differential roles of G(q/11), Gi and G(12/13) proteins in signalling by alpha1-adrenergic, endothelin-1 and thrombin-sensitive protease-activated receptors.

  2005cited by this paper
• JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis

  2004cited by this paper
• Differential Contribution of GTPase Activation and Effector Antagonism to the Inhibitory Effect of RGS Proteins on Gq-mediated Signaling in Vivo*

  2004cited by this paper
• Synchronous activation of ERK 1/2, p38mapk and PKB/Akt signaling by H2O2 in vascular smooth muscle cells: potential involvement in vascular disease (review).

  2003cited by this paper
• Akt and PI 3-Kinase Signaling in Cardiomyocyte Hypertrophy and Survival

  2003cited by this paper
• Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention

  2003influential reference
• Role of MAP kinase in tumor progression and invasion

  2003cited by this paper
• A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?

  2003cited by this paper
• PI3K/Akt and apoptosis: size matters

  2003cited by this paper
• Regulators of G-protein signalling: multifunctional proteins with impact on signalling in the cardiovascular system.

  2003influential reference
• Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).

  2003influential reference
• MAPK regulation of gene expression in airway smooth muscle.

  2003cited by this paper
• G protein-coupled receptor cross-talk: pivotal roles of protein phosphorylation and protein-protein interactions.

  2003cited by this paper
• Muscarinic receptor subtype determines vulnerability to oxidative stress in COS-7 cells.

  2002influential reference
• The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia

  2002cited by this paper
• Characterization and comparison of RGS2 and RGS4 as GTPase-activating proteins for m2 muscarinic receptor-stimulated Gi

  2002cited by this paper
• Receptor-selective Effects of Endogenous RGS3 and RGS5 to Regulate Mitogen-activated Protein Kinase Activation in Rat Vascular Smooth Muscle Cells*

  2002influential reference
• Role of Akt Signaling in Vascular Homeostasis and Angiogenesis

  2002cited by this paper
• The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system.

  2002cited by this paper
• Characterization and comparison of RGS2 and RGS4 as GTPase-activating proteins for m2 muscarinic receptor-stimulated G(i).

  2002cited by this paper
• Cellular Regulation of RGS Proteins: Modulators and Integrators of G Protein Signaling

  2002cited by this paper
• Reassembly of phospholipase C-beta2 from separated domains: analysis of basal and G protein-stimulated activities.

  2001cited by this paper
• Sphingosine 1-Phosphate and Activation of Endothelial Nitric-oxide Synthase

  2001cited by this paper
• Regulator of G-protein Signaling 3 (RGS3) Inhibits Gβ1γ2-induced Inositol Phosphate Production, Mitogen-activated Protein Kinase Activation, and Akt Activation*

  2001influential reference
• RGS2 blocks slow muscarinic inhibition of N‐type Ca2+ channels reconstituted in a human cell line

  2001cited by this paper
• Regulation of phosphoinositide-specific phospholipase C.

  2001cited by this paper
• Activation of extracellular signal-regulated kinase (ERK) and Akt by human serotonin 5-HT(1B) receptors in transfected BE(2)-C neuroblastoma cells is inhibited by RGS4.

  2000cited by this paper
• Activation of Extracellular Signal‐Regulated Kinase (ERK) and Akt by Human Serotonin 5‐HT1B Receptors in Transfected BE(2)‐C Neuroblastoma Cells Is Inhibited by RGS4

  2000influential reference
• Regulator of G Protein Signaling RGS3T Is Localized to the Nucleus and Induces Apoptosis*

  2000influential reference
• Erk1/2-dependent Phosphorylation of Gα-interacting Protein Stimulates Its GTPase Accelerating Activity and Autophagy in Human Colon Cancer Cells*

  2000cited by this paper
• GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins.

  2000influential reference
• Dual Regulation of Akt/Protein Kinase B by Heterotrimeric G Protein Subunits*

  2000cited by this paper
• Structure, function, and control of phosphoinositide-specific phospholipase C.

  2000cited by this paper
• RGS Molecule Expression in Murine B Lymphocytes and Ability to Down-Regulate Chemotaxis to Lymphoid Chemokines1 2

  2000cited by this paper
• G Protein Selectivity Is a Determinant of RGS2 Function*

  1999cited by this paper
• The stress-activated protein kinase pathways

  1999cited by this paper
• Use of a Sandwich Enzyme-linked Immunosorbent Assay Strategy to Study Mechanisms of G Protein-coupled Receptor Assembly*

  1999influential reference
• RGS16 Attenuates Gαq-dependent p38 Mitogen-activated Protein Kinase Activation by Platelet-activating Factor*

  1999cited by this paper
• Gq signaling in cardiac adaptation and maladaptation.

  1999cited by this paper
• Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice.

  1999cited by this paper
• Low- and high-level transgenic expression of β2-adrenergic receptors differentially affect cardiac hypertrophy and function in Gαq-overexpressing mice

  1999cited by this paper
• Cardiac myocytes express mRNA for ten RGS proteins: changes in RGS mRNA expression in ventricular myocytes and cultured atria

  1998influential reference
• Activation of Akt/Protein Kinase B by G Protein-coupled Receptors

  1998cited by this paper
• RGS2/G0S8 is a selective inhibitor of Gqalpha function.

  1997cited by this paper
• Characterization of a Novel Mammalian RGS Protein That Binds to Gα Proteins and Inhibits Pheromone Signaling in Yeast*

  1997cited by this paper
• A Truncated Form of RGS3 Negatively Regulates G Protein-coupled Receptor Stimulation of Adenylyl Cyclase and Phosphoinositide Phospholipase C*

  1997cited by this paper
• Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors

  1997cited by this paper
• RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha.

  1997influential reference
• RGS2/G0S8 is a selective inhibitor of Gqα function

  1997influential reference
• RGS4 Inhibits Gq-mediated Activation of Mitogen-activated Protein Kinase and Phosphoinositide Synthesis*

  1997influential reference
• The GTPase-activating Protein RGS4 Stabilizes the Transition State for Nucleotide Hydrolysis*

  1996cited by this paper
• Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family

  1996influential reference
• Heterotrimeric G proteins: organizers of transmembrane signals.

  1995cited by this paper
• Nobel Lecture. G proteins and regulation of adenylyl cyclase.

  1995cited by this paper
• Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.

  1994influential reference
• Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

  1994cited by this paper
• Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

  1994cited by this paper
• G proteins and regulation of adenylyl cyclase

  1989cited by this paper

• RGS2-Related Non-coding Interaction Network Modulates the NF-Kappa B Signaling Pathway in MS Patients: A Systems Biology Investigation

  2025cites this paper
• Germline deletion of Rgs2 and/or Rgs5 in male mice does not exacerbate left ventricular remodeling induced by subchronic isoproterenol infusion

  2025cites this paper
• Modulation of neural gene networks by estradiol in old rhesus macaque females

  2024cites this paper
• Phosphodiesterases Mediate the Augmentation of Myogenic Constriction by Inhibitory G Protein Signaling and is Negatively Modulated by the Dual Action of RGS2 and 5

  2024cites this paper
• Modulation of neural gene networks by estradiol in old rhesus macaque females

  2023cites this paper
• Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias and disrupts the fine-tuning of Gi/o signaling

  2022cites this paper
• PI3K/Akt pathway mediates the positive inotropic effects of insulin in Langendorff-perfused rat hearts

  2022cites this paper
• ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth

  2021cites this paper
• The GNAQ T96S Mutation Affects Cell Signaling and Enhances the Oncogenic Properties of Hepatocellular Carcinoma

  2021cites this paper
• RGS5–TGFβ–Smad2/3 axis switches pro- to anti-apoptotic signaling in tumor-residing pericytes, assisting tumor growth

  2021cites this paper
• Regulator of G‐Protein Signaling 16 Is a Negative Modulator of Platelet Function and Thrombosis

  2019cites this paper
• Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy.

  2019cites this paper
• PPARγ Agonist PGZ Attenuates OVA-Induced Airway Inflammation and Airway Remodeling via RGS4 Signaling in Mouse Model

  2018cites this paper
• Regulation of Cardiac Hypertrophy and Metabolism by Regulator of G Protein Signalling 2 (RGS2)

  2017cites this paper
• Cardiomyocyte specific overexpression of a 37 amino acid domain of regulator of G protein signalling 2 inhibits cardiac hypertrophy and improves function in response to pressure overload in mice.

  2017cites this paper
• EphrinB2/EphB4 pathway in postnatal angiogenesis: a potential therapeutic target for ischemic cardiovascular disease

  2016cites this paper
• Post‐cocaine changes in regulator of G‐protein signaling (RGS) proteins in the dorsal striatum: Relevance for cocaine‐seeking and protein kinase C‐mediated phosphorylation

  2016cites this paper
• Homer3 regulates the establishment of neutrophil polarity

  2015influential citation
• Regulator of G Protein Signaling 1 Suppresses CXCL12-Mediated Migration and AKT Activation in RPMI 8226 Human Plasmacytoma Cells and Plasmablasts

  2015cites this paper
• PDZ Protein Regulation of G Protein–Coupled Receptor Trafficking and Signaling Pathways

  2015influential citation
• RGS2 and RGS4 proteins: New modulators of the κ-opioid receptor signaling.

  2015cites this paper
• Investigation into the effects of specific muscarinic acetylcholine receptor antagonists on the myocardium in pre-clinical conditions of ischaemia reperfusion injury and oxidative stress model

  2015cites this paper
• Role of RGS2 in Cellular Stress

  2015cites this paper
• Regulator of G-protein signaling 5 is expressed in hepatic stellate cells and moderates the fibrotic response to injury

  2015cites this paper
• The ORF3 protein of porcine circovirus type 2 promotes secretion of IL-6 and IL-8 in porcine epithelial cells by facilitating proteasomal degradation of regulator of G protein signalling 16 through physical interaction.

  2015influential citation
• Ïàðàñèìïàòè÷åñêàÿ ðåãóëÿöèÿ ÿâëÿåòñÿ âàæíåéøèì ôàêòîðîì ðåãóëÿöèè ñåð- äöà ìëåêîïèòàþùèõ. Ðåãóëÿòîðíûå âëèÿíèÿ ïàðàñèìïàòè÷åñêîãî îòäåëà âåãåòà- òèâíîé íåðâíîé ñèñòåìu

  2015cites this paper
• RGS Redundancy and Implications in GPCR-GIRK Signaling.

  2015cites this paper
• Regulation of Gβγi-Dependent PLC-β3 Activity in Smooth Muscle: Inhibitory Phosphorylation of PLC-β3 by PKA and PKG and Stimulatory Phosphorylation of Gαi-GTPase-Activating Protein RGS2 by PKG

  2014cites this paper
• Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease

  2014influential citation
• Regulator of G-Protein Signaling-5 Is a Marker of Hepatic Stellate Cells and Expression Mediates Response to Liver Injury

  2014cites this paper
• Regulator of G protein signaling 2 (RGS2) deficiency accelerates the progression of kidney fibrosis.

  2014cites this paper
• Role of regulator of G protein signaling proteins in bone.

  2014cites this paper
• The effect of deficient muscarinic signaling on commonly reported biochemical effects in schizophrenia and convergence with genetic susceptibility loci in explaining symptom dimensions of psychosis

  2014influential citation
• Regulator of G-protein signaling-5 inhibits bronchial smooth muscle contraction in severe asthma.

  2012cites this paper
• The other side of opioid receptor signalling: regulation by protein-protein interaction.

  2012cites this paper
• Peculiar Effects of Muscarinic M1, M2, and M3 Receptor Blockers on Cardiac Chronotropic Function in Neonatal Rats

  2012cites this paper
• The relationship between RGS5 expression and cancer differentiation and metastasis in non‐small cell lung cancer

  2012cites this paper
• Regulator of G protein signaling proteins as drug targets: current state and future possibilities.

  2011cites this paper
• Decreased Striatal RGS2 Expression Is Neuroprotective in Huntington's Disease (HD) and Exemplifies a Compensatory Aspect of HD-Induced Gene Regulation

  2011influential citation
• Multiple protein kinases determine the phosphorylated state of the small heat shock protein, HSP27, in SH-SY5Y neuroblastoma cells.

  2011cites this paper
• Treating schizophrenia: novel targets for the cholinergic system.

  2010cites this paper
• Regulators of G protein signaling proteins as targets for drug discovery.

  2010cites this paper
• Combinaison de pilocarpine et de méthimazol destinée au traitement de la maladie de charcot-marie-tooth et de troubles associés

  2009cites this paper
• Characterization of human septic sera induced gene expression modulation in human myocytes.

  2009cites this paper
• Novel signaling pathways promote a paracrine wave of prostacyclin-induced vascular smooth muscle differentiation.

  2009cites this paper
• Regulation of cardiovascular GPCR signalling

  2009cites this paper
• Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE 5 inhibition in mice

  2009cites this paper
• Pro- and anti-apoptotic dual functions of the C5a receptor: involvement of regulator of G protein signaling 3 and extracellular signal-regulated kinase

  2009cites this paper
• Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.

  2009cites this paper
• Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate mu- and delta-opioid receptor signaling.

  2009cites this paper
• Regulation of G protein-coupled receptor signalling: focus on the cardiovascular system and regulator of G protein signalling proteins.

  2008cites this paper
• Kombination aus Pilocarpin und Methimazol zur Behandlung der Charcot-Marie-Tooth Krankheit und verwandten Erkrankungen

  2008cites this paper
• Statins stimulate RGS-regulated ERK 1/2 activation in human calcified and stenotic aortic valves.

  2008cites this paper
• Role of endogenous RGS proteins on endothelial ERK 1/2 activation.

  2008cites this paper
• Iranian Journal of Basic Medical Sciences Micrornas That Target Rgs5

  year unknowncites this paper