Cannabinoid CB1 receptors in the medial prefrontal cortex modulate the expression of contextual fear conditioning.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  International Journal of Neuropsychopharmacology

• Publication date

  2010-10-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1017/S1461145710000684PMID 20587131
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Integrated cannabinoid CB1 receptor transmission within the amygdala-prefrontal cortical pathway modulates neuronal plasticity and emotional memory encoding.

  2010cited by this paper
• Involvement of the prelimbic prefrontal cortex on cannabidiol-induced attenuation of contextual conditioned fear in rats.

  2010cited by this paper
• Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin‐releasing hormone signaling

  2009cited by this paper
• Opposite role of infralimbic and prelimbic cortex in the tachycardiac response evoked by acute restraint stress in rats

  2009cited by this paper
• The role of prefrontal cortex CB1 receptors in the modulation of fear memory.

  2009cited by this paper
• A Discrete GABAergic Relay Mediates Medial Prefrontal Cortical Inhibition of the Neuroendocrine Stress Response

  2009cited by this paper
• Endocannabinoid system and fear conditioning.

  2009cited by this paper
• Endocannabinoid signals in the control of emotion.

  2009cited by this paper
• Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment

  2008cited by this paper
• Chronic cannabinoid administration in vivo compromises extinction of fear memory.

  2008cited by this paper
• Effects of reversible inactivation of the dorsal hippocampus on the behavioral and cardiovascular responses to an aversive conditioned context

  2008cited by this paper
• Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex.

  2008cited by this paper
• Endocannabinoid modulation of fear responses: learning and state-dependent performance effects

  2008cited by this paper
• Anxiolytic-like effects induced by acute reversible inactivation of the bed nucleus of stria terminalis.

  2008cited by this paper
• Anxiolytic-like effects induced by medial prefrontal cortex inhibition in rats submitted to the Vogel conflict test.

  2008cited by this paper
• Activation of cannabinoid CB1 receptors in the dorsolateral periaqueductal gray induces anxiolytic effects in rats submitted to the Vogel conflict test.

  2008cited by this paper
• Activation of CB1 cannabinoid receptors in the dorsolateral periaqueductal gray reduces the expression of contextual fear conditioning in rats

  2008cited by this paper
• CB1 receptor stimulation in specific brain areas differently modulate anxiety-related behaviour.

  2008cited by this paper
• The disruptive effects of the CB1 receptor antagonist rimonabant on extinction learning in mice are task-specific

  2007cited by this paper
• Activity in Prelimbic Cortex Is Necessary for the Expression of Learned, But Not Innate, Fears

  2007cited by this paper
• The Expression of Contextual Fear Conditioning Involves Activation of an NMDA Receptor–Nitric Oxide Pathway in the Medial Prefrontal Cortex

  2007cited by this paper
• Anxiolytic-Like Properties of the Anandamide Transport Inhibitor AM404

  2006cited by this paper
• Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear.

  2006cited by this paper
• Cannabinoid CB1 Receptor Mediates Fear Extinction via Habituation-Like Processes

  2006influential reference
• Involvement of the medial prefrontal cortex in central cardiovascular modulation in the rat.

  2006cited by this paper
• The effects of cannabinoids on contextual conditioned fear in CB1 knockout and CD1 mice

  2006cited by this paper
• Cannabinoids Potentiate Emotional Learning Plasticity in Neurons of the Medial Prefrontal Cortex through Basolateral Amygdala Inputs

  2006cited by this paper
• The cannabinoid receptor agonist WIN 55,212-2 facilitates the extinction of contextual fear memory and spatial memory in rats

  2006influential reference
• Effects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in rats.

  2006cited by this paper
• Inactivation of the ventromedial prefrontal cortex reduces expression of conditioned fear and impairs subsequent recall of extinction

  2006influential reference
• Involvement of medial prefrontal cortex neurons in behavioral and cardiovascular responses to contextual fear conditioning.

  2006influential reference
• Pharmacological Evaluation of Cannabinoid Receptor Ligands in a Mouse Model of Anxiety: Further Evidence for an Anxiolytic Role for Endogenous Cannabinoid Signaling

  2006cited by this paper
• Blockade of cannabinoid CB1 receptors alters contextual learning and memory.

  2006influential reference
• A neuroendocrine mechanism for sustaining fear.

  2005cited by this paper
• Footshock intensity and generalization in contextual and auditory-cued fear conditioning in the rat.

  2004influential reference
• Consolidation of Fear Extinction Requires Protein Synthesis in the Medial Prefrontal Cortex

  2004cited by this paper
• Memory Reconsolidation and Extinction Have Distinct Temporal and Biochemical Signatures

  2004cited by this paper
• Significance of dopamine transmission in the rat medial prefrontal cortex for conditioned fear.

  2003cited by this paper
• Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling.

  2003cited by this paper
• Functions of cannabinoid receptors in the hippocampus.

  2002cited by this paper
• The endogenous cannabinoid system controls extinction of aversive memories

  2002cited by this paper
• Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses

  2001cited by this paper
• Presynaptic specificity of endocannabinoid signaling in the hippocampus.

  2001cited by this paper
• Activation of CB1 cannabinoid receptors in rat hippocampal slices inhibits potassium-evoked cholecystokinin release, a possible mechanism contributing to the spatial memory defects produced by cannabinoids.

  2001cited by this paper
• The Role of Ventromedial Prefrontal Cortex in the Recovery of Extinguished Fear

  2000cited by this paper
• Cannabinoids modulate synaptic strength and plasticity at glutamatergic synapses of rat prefrontal cortex pyramidal neurons.

  2000influential reference
• Cholinergic inputs to the rat medial prefrontal cortex mediate potentiation of the cardiovascular defensive response by the anxiogenic benzodiazephine receptor partial inverse agonist FG 7142.

  1999cited by this paper
• Blockade of cannabinoid receptors by SR141716 selectively increases Fos expression in rat mesocorticolimbic areas via reduced dopamine D2 function.

  1999cited by this paper
• Cortical modulation of the cardiovascular system.

  1998cited by this paper
• Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system.

  1998cited by this paper
• A central cholinergic link in the cardiovascular effects of the benzodiazepine receptor partial inverse agonist FG 7142.

  1996influential reference
• Structure-activity relationships defining the ACD-tricyclic cannabinoids: cannabinoid receptor binding and analgesic activity.

  1995cited by this paper
• Pharmacology of cannabinoid receptors.

  1995cited by this paper
• Conditioned fear-induced changes in behavior and in the expression of the immediate early gene c-fos: with and without diazepam pretreatment

  1995cited by this paper
• The effect of medial frontal cortex lesions on cardiovascular conditioned emotional responses in the rat.

  1994cited by this paper
• Cardiovascular effects of the benzodiazepine receptor partial inverse agonist FG 7142 in rats.

  1994cited by this paper
• Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study

  1991cited by this paper
• Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear

  1988cited by this paper
• Determination and characterization of a cannabinoid receptor in rat brain.

  1988cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983influential reference
• Conditional and unconditional components of post-shock freezing

  1980cited by this paper
• Passive and active reactions to fear-eliciting stimuli.

  1969cited by this paper

• The conditioned emotional response evoked by contextual fear is modulated by lateral hypothalamus synaptic activity without the involvement of GABAA receptor activation.

  2025cites this paper
• The expression of contextual fear conditioning involves the dorsal hippocampus TRPV1 receptor interacting with the NMDA/NO/cGMP signalling pathway

  2024influential citation
• The medial prefrontal cortex and the cardiac baroreflex activity: physiological and pathological implications

  2023cites this paper
• Interplay between endocannabinoid and endovanilloid mechanisms in fear conditioning

  2023influential citation
• The neural circuits and molecular mechanisms underlying fear dysregulation in posttraumatic stress disorder

  2023cites this paper
• Update on neurobiological mechanisms of fear: illuminating the direction of mechanism exploration and treatment development of trauma and fear-related disorders

  2023cites this paper
• Contextual fear expression engages a complex set of interactions between ventromedial prefrontal cortex cholinergic, glutamatergic, nitrergic and cannabinergic signaling.

  2023cites this paper
• Bed nucleus of the stria terminalis CB1 receptors and the FAAH enzyme modulate anxiety behavior depending on previous stress exposure.

  2023cites this paper
• Increased cannabis intake during the COVID-19 pandemic is associated with worsening of depression symptoms in people with PTSD

  2022cites this paper
• Effects of selective orexin receptor‐2 and cannabinoid receptor‐1 antagonists on the response of medial prefrontal cortex neurons to tramadol

  2022cites this paper
• Fatty acid amide hydrolase levels in brain linked with threat-related amygdala activation

  2022cites this paper
• Memory consolidation depends on endogenous hippocampal levels of anandamide: CB1 and M4, but possibly not TRPV1 receptors mediate AM404 effects.

  2022cites this paper
• Inducible Nitric Oxide Synthase Inhibition in the Medial Prefrontal Cortex Attenuates the Anxiogenic-Like Effect of Acute Restraint Stress via CB1 Receptors

  2022cites this paper
• Book Review: Cannabinoids and Neuropsychiatric Disorders

  2021cites this paper
• The role of the cannabinoid system in fear memory and extinction in male and female mice

  2021cites this paper
• The role of endocannabinoids in consolidation, retrieval, reconsolidation, and extinction of fear memory

  2021influential citation
• Cannabinoids: revealing their complexity and role in central networks of fear and anxiety.

  2021cites this paper
• Exploring Novel Treatment Approaches for Post-Traumatic Stress Disorder

  2020influential citation
• Attenuation of fear‐conditioned analgesia in rats by monoacylglycerol lipase inhibition in the anterior cingulate cortex: Potential role for CB2 receptors

  2020cites this paper
• Differential modulation of the contextual conditioned emotional response by CB1 and TRPV1 receptors in the ventromedial prefrontal cortex: Possible involvement of NMDA/nitric oxide-related mechanisms

  2020cites this paper
• Effect of the ZiBuPiYin Recipe on Diabetes-Associated Cognitive Decline in Zucker Diabetic Fatty Rats After Chronic Psychological Stress

  2020cites this paper
• Hypothalamic endocannabinoid signalling modulates aversive responses related to panic attacks

  2019cites this paper
• Role of the endocannabinoid system in the dorsal hippocampus in the cardiovascular changes and delayed anxiety-like effect induced by acute restraint stress in rats

  2019cites this paper
• Endocannabinoid interactions in the regulation of acquisition of contextual conditioned fear

  2019influential citation
• Tempering aversive/traumatic memories with cannabinoids: a review of evidence from animal and human studies

  2019cites this paper
• Bidirectional influence of amygdala β1-adrenoceptors blockade on cannabinoid signaling in contextual and auditory fear memory

  2018cites this paper
• The prefrontal cortical endocannabinoid system modulates fear–pain interactions in a subregion‐specific manner

  2018cites this paper
• Mechanisms underlying the effects of n-3 polyunsaturated fatty acids on fear memory processing and their hypothetical effects on fear of cancer recurrence in cancer survivors.

  2018cites this paper
• Medial prefrontal cortex TRPV1 and CB1 receptors modulate cardiac baroreflex activity by regulating the NMDA receptor/nitric oxide pathway

  2018cites this paper
• The role of the endocannabinoid system in the emotional modulation of pain

  2018influential citation
• Berberine Ameliorates Diabetes-Associated Cognitive Decline through Modulation of Aberrant Inflammation Response and Insulin Signaling Pathway in DM Rats

  2017cites this paper
• Methamidophos, an Organophosphorus Insecticide, Induces Pro-aggressive Behaviour in Mice

  2017cites this paper
• Neuroactive steroids and PTSD treatment.

  2017cites this paper
• The Endocannabinoid System and Anxiety.

  2017cites this paper
• Neurosteroid biosynthesis down‐regulation and changes in GABAA receptor subunit composition: a biomarker axis in stress‐induced cognitive and emotional impairment

  2017cites this paper
• The Endocannabinoid System in the Control of Behavior

  2017cites this paper
• Prefrontal endocannabinoids, stress controllability and resilience: A hypothesis

  2017cites this paper
• Endocannabinoid Signaling in Neural Circuits of the Olfactory and Limbic System

  2016influential citation
• Developmental regulation of fear learning and anxiety behavior by endocannabinoids

  2016cites this paper
• 1 modulates baroreflex activity through CB Medial prefrontal cortex endocannabinoid system

  2016cites this paper
• Dorsolateral periaqueductal gray matter CB1 and TRPV1 receptors exert opposite modulation on expression of contextual fear conditioning.

  2016cites this paper
• Modulation of Long-Term Potentiation of Cortico-Amygdala Synaptic Responses and Auditory Fear Memory by Dietary Polyunsaturated Fatty Acid

  2016influential citation
• Involvement of endocannabinoid neurotransmission in the bed nucleus of stria terminalis in cardiovascular responses to acute restraint stress in rats

  2016influential citation
• Dorsal hippocampus cannabinoid type 1 receptors modulate the expression of contextual fear conditioning in rats: Involvement of local glutamatergic/nitrergic and GABAergic neurotransmissions.

  2016cites this paper
• Modulation of cannabinoid signaling by amygdala α2-adrenergic system in fear conditioning.

  2016cites this paper
• Cannabinoid Control of Fear Responses

  2015cites this paper
• Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: additional evidence.

  2015cites this paper
• M3 muscarinic receptor in the ventral medial prefrontal cortex modulating the expression of contextual fear conditioning in rats

  2015cites this paper
• Medial prefrontal cortex TRPV1 channels modulate the baroreflex cardiac activity in rats

  2015cites this paper
• κ‐Opioid receptors in the infralimbic cortex modulate the cardiovascular responses to acute stress

  2015cites this paper
• The role of endocannabinoid function in posttraumatic stress disorder: Modulating the risk phenotype and rendering effects of trauma

  2015cites this paper
• Efeito do canabidiol sobre a reconsolidação da memória de medo ao contexto: envolvimento dos receptores CB1 do córtex pré-límbico

  2014cites this paper
• FROM THE NEUROBIOLOGY OF EXTINCTION TO IMPROVED CLINICAL TREATMENTS

  2014cites this paper
• Inhibition of endocannabinoid neuronal uptake and hydrolysis as strategies for developing anxiolytic drugs

  2014cites this paper
• Modulation of Fear Memory by Dietary Polyunsaturated Fatty Acids via Cannabinoid Receptors

  2014cites this paper
• Schizophrenia and Endocannabinoid Signaling in the Prefrontal Cortex

  2014cites this paper
• Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing

  2014cites this paper
• A critical role for prefrontocortical endocannabinoid signaling in the regulation of stress and emotional behavior.

  2014cites this paper
• Programming of cardiovascular and metabolic functions by thyroid hormone signaling

  2014cites this paper
• Medial prefrontal cortex Transient Receptor Potential Vanilloid Type 1 (TRPV1) in the expression of contextual fear conditioning in Wistar rats

  2013cites this paper
• Cannabinoid modulation of chronic mild stress-induced selective enhancement of trace fear conditioning in adolescent rats

  2013cites this paper
• and Michael S Weiss conditioning in adolescent rats Cannabinoid modulation of chronic mild stress-induced selective enhancement of trace fear

  2013cites this paper
• Effects of endocannabinoid and endovanilloid systems on aversive memory extinction.

  2013cites this paper
• Endocannabinoid system and mood disorders: priming a target for new therapies.

  2013cites this paper
• Predator threat stress promotes long lasting anxiety-like behaviors and modulates synaptophysin and CB1 receptors expression in brain areas associated with PTSD symptoms.

  2013cites this paper
• Conditioned fear is modulated by CRF mechanisms in the periaqueductal gray columns.

  2013cites this paper
• Medial prefrontal cortex neuronal circuits in fear behavior.

  2013cites this paper
• Os receptores TRPV1 do córtex pré-frontal medial ventral modulam a atividade do barorreflexo cardíaco em ratos

  2013cites this paper
• The endocannabinoid system in anxiety, fear memory and habituation

  2012cites this paper
• Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo.

  2012cites this paper
• Fear relief-toward a new conceptual frame work and what endocannabinoids gotta do with it.

  2012cites this paper
• Neuroanatomical substrates involved in cannabinoid modulation of defensive responses

  2012cites this paper
• Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels in fear and anxiety-two sides of one coin?

  2012cites this paper
• Effects of LTD-blocking Tat-GluR2 Peptide on Contextual Fear Memory Impairments Induced by Cannabinoids

  2012influential citation
• Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder.

  2012cites this paper
• Postsynaptic diacylglycerol lipase α mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex

  2011cites this paper
• Participação do sistema glutamatérgico do córtex pré-frontal medial ventral na modulação das consequências comportamentais do estresse de nado forçado

  2011cites this paper
• Medial prefrontal cortex endocannabinoid system modulates baroreflex activity through CB(1) receptors.

  2011cites this paper
• Different role of the ventral medial prefrontal cortex on modulation of innate and associative learned fear.

  2010cites this paper