Follicle-stimulating hormone promotes nuclear exclusion of the forkhead transcription factor FoxO1a via phosphatidylinositol 3-kinase in porcine granulosa cells.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Endocrinology

• Publication date

  2003-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/EN.2003-0678PMID 12960025
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The forkhead transcription factor Foxo1 regulates adipocyte differentiation.

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• The phosphoinositide 3-kinase pathway.

  2002cited by this paper
• Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropins.

  2002influential reference
• Regulation of the FoxO family of transcription factors by phosphatidylinositol-3 kinase-activated signaling.

  2002cited by this paper
• Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.

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• Activation of the Akt/Protein Kinase B Signaling Pathway Is Associated with Granulosa Cell Survival1

  2001cited by this paper
• Protein Kinase SGK Mediates Survival Signals by Phosphorylating the Forkhead Transcription Factor FKHRL1 (FOXO3a)

  2001cited by this paper
• IGF-I receptor signalling in transformation and differentiation

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• PKB/AKT: functional insights from genetic models

  2001cited by this paper
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  2000cited by this paper
• Follicle-Stimulating hormone (FSH) stimulates phosphorylation and activation of protein kinase B (PKB/Akt) and serum and glucocorticoid-lnduced kinase (Sgk): evidence for A kinase-independent signaling by FSH in granulosa cells.

  2000influential reference
• Putative role of the phosphatidylinositol 3-kinase — Akt signaling pathway in the survival of granulosa cells

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• Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN

  2000cited by this paper
• Importance of the IGF system in early folliculogenesis.

  2000influential reference
• Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway*

  1999cited by this paper
• Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1.

  1999cited by this paper
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  1999cited by this paper
• Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B*

  1999cited by this paper
• Insulin‐like Growth Factors and Ovarian Physiology

  1998cited by this paper
• Mechanism of activation and function of protein kinase B.

  1998cited by this paper
• Hormonal regulation of apoptosis in early antral follicles: follicle-stimulating hormone as a major survival factor.

  1996cited by this paper
• Epidermal growth factor inhibits large granulosa cell apoptosis by stimulating progesterone synthesis and regulating the distribution of intracellular free calcium.

  1994cited by this paper
• Ovarian follicle atresia: a hormonally controlled apoptotic process.

  1994cited by this paper
• Gonadotropin suppression of apoptosis in cultured preovulatory follicles: mediatory role of endogenous insulin-like growth factor I.

  1994cited by this paper
• Apoptosis in atretic ovarian follicles is associated with selective decreases in messenger ribonucleic acid transcripts for gonadotropin receptors and cytochrome P450 aromatase.

  1992cited by this paper
• Production of insulin-like growth factor binding proteins (IGFBPs) by porcine granulosa cells: identification of IGFBP-2 and -3 and regulation by hormones and growth factors.

  1990cited by this paper

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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2005cites this paper
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  2005influential citation
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