microRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Carcinogenesis

• Publication date

  2010-10-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1093/carcin/bgq119PMID 20643754PMCID PMC2950932
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of oxidatively induced DNA lesions in human pathogenesis.

  2010cited by this paper
• Ionizing Radiation-Induced Oxidative Stress Alters miRNA Expression

  2009cited by this paper
• miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: An essential role for apoptosis.

  2009cited by this paper
• Bystander effect induced changes in apoptosis related proteins and terminal differentiation in in vitro murine bladder cultures

  2009cited by this paper
• Aberration‐corrected microscopy for structural biology applications

  2009cited by this paper
• MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells.

  2009cited by this paper
• γH2AX and cancer

  2008cited by this paper
• miR‐15b and miR‐16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells

  2008cited by this paper
• DNA damage-induced upregulation of miR-709 in the germline downregulates BORIS to counteract aberrant DNA hypomethylation

  2008cited by this paper
• Sex-specific microRNAome deregulation in the shielded bystander spleen of cranially exposed mice

  2008cited by this paper
• LNA-mediated microRNA silencing in non-human primates

  2008cited by this paper
• Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling.

  2008cited by this paper
• Getting to the root of miRNA-mediated gene silencing.

  2008cited by this paper
• Altered microRNA expression patterns in irradiated hematopoietic tissues suggest a sex-specific protective mechanism.

  2008cited by this paper
• miRiad roles for the miR-17-92 cluster in development and disease.

  2008cited by this paper
• Toward microRNA-based therapeutics for heart disease: the sense in antisense.

  2008cited by this paper
• Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin

  2008cited by this paper
• Non-targeted and delayed effects of exposure to ionizing radiation

  2007cited by this paper
• Myc goes global: new tricks for an old oncogene.

  2007cited by this paper
• MicroRNAs and Cell Cycle Regulation

  2007cited by this paper
• Modulation of Radiation Responses by Pre-exposure to Irradiated Cell Conditioned Medium

  2007cited by this paper
• Intestinal Epithelial Cell Dysfunction is Mediated by an Endothelial-Specific Radiation-Induced Bystander Effect

  2007cited by this paper
• DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models.

  2007cited by this paper
• “Myc’ed Messages”: Myc Induces Transcription of E2F1 while Inhibiting Its Translation via a microRNA Polycistron

  2007cited by this paper
• mir-29 regulates Mcl-1 protein expression and apoptosis

  2007influential reference
• Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo.

  2007cited by this paper
• c‐Myc primed mitochondria determine cellular sensitivity to TRAIL‐induced apoptosis

  2007cited by this paper
• Small RNAs, big potential: the role of MicroRNAs in stem cell function.

  2007cited by this paper
• Role of tumor necrosis factor-alpha and TRAIL in high-dose radiation-induced bystander signaling in lung adenocarcinoma.

  2007cited by this paper
• MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B

  2007cited by this paper
• c-Myc Blazing a Trail of Death: Coupling of the Mitochondrial and Death Receptor Apoptosis Pathways by c-Myc

  2007cited by this paper
• Molecular Genetics of RB1——The Retinoblastoma Gene

  2007cited by this paper
• Non-targeted bystander effects induced by ionizing radiation.

  2007cited by this paper
• Untargeted effects of ionizing radiation: implications for radiation pathology.

  2006cited by this paper
• The Involvement of Calcium and MAP Kinase Signaling Pathways in the Production of Radiation-Induced Bystander Effects

  2006cited by this paper
• A microRNA expression signature of human solid tumors defines cancer gene targets

  2006cited by this paper
• Bystander-induced differentiation: a major response to targeted irradiation of a urothelial explant model.

  2006cited by this paper
• miRNAs and apoptosis: RNAs to die for

  2006cited by this paper
• Radiation-induced genomic instability is associated with DNA methylation changes in cultured human keratinocytes.

  2006cited by this paper
• Bystander responses in three-dimensional cultures containing radiolabelled and unlabelled human cells.

  2006cited by this paper
• Induction of Apoptosis in Mouse Liver by Microcystin-LR

  2005cited by this paper
• Assessment of low linear energy transfer radiation-induced bystander mutagenesis in a three-dimensional culture model.

  2005cited by this paper
• c-Myc-regulated microRNAs modulate E2F1 expression

  2005cited by this paper
• Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts

  2005cited by this paper
• Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away.

  2005cited by this paper
• Radiation-induced bystander effects — implications for cancer

  2004cited by this paper
• A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

  2003cited by this paper
• E2F1 and c-Myc in Cell Growth and Death

  2003cited by this paper
• Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation?

  2003cited by this paper
• Cell to cell contact required for bystander effect of the TNF-related apoptosis-inducing ligand (TRAIL) gene.

  2003cited by this paper
• Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

  2003cited by this paper
• Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: I. Radiation-Induced Genomic Instability and Bystander Effects In Vitro

  2003cited by this paper
• Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: II. Radiation-Induced Genomic Instability and Bystander Effects In Vivo, Clastogenic Factors and Transgenerational Effects

  2003cited by this paper
• Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

  2002cited by this paper
• Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells.

  2001cited by this paper
• Characterization and comparison of reconstructed skin models: morphological and immunohistochemical evaluation.

  2000cited by this paper
• Cluster analysis and display of genome-wide expression patterns.

  1998cited by this paper
• DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139*

  1998cited by this paper
• Apoptotic cell death induced by c-myc is inhibited by bcl-2

  1992cited by this paper

• Radiation Without Borders: Unraveling Bystander and Non-Targeted Effects in Oncology

  2025cites this paper
• Biophoton signaling in mediation of cell-to-cell communication and radiation-induced bystander effects

  2024cites this paper
• Epigenetic modifications in radiation-induced non-targeted effects and their clinical significance.

  2023cites this paper
• Observation of Histone H2AX Phosphorylation by Radiation-Induced Bystander Response Using Titanium Characteristic X-ray Microbeam

  2023cites this paper
• The Footprint of Exosomes in the Radiation-Induced Bystander Effects

  2022cites this paper
• Exosomes Participate in the Radiotherapy Resistance of Cancers

  2022cites this paper
• Radiation-Induced Bystander Effect and Cytoplasmic Irradiation Studies with Microbeams

  2022cites this paper
• Sins of fathers through a scientific lens: Transgenerational effects

  2021cites this paper
• External modulators and redox homeostasis: Scenario in radiation-induced bystander cells.

  2021cites this paper
• Role of epigenetic mechanisms in propagating off-targeted effects following radiation based therapies - A review.

  2021cites this paper
• Exosome-mediated radiosensitizing effect on neighboring cancer cells via increase in intracellular levels of reactive oxygen species

  2021cites this paper
• Radiation-Induced Bystander Effect can be Transmitted Through Exosomes Using miRNAs as Effector Molecules

  2020cites this paper
• Proton Irradiation Platforms for Preclinical Studies of High-Dose-Rate (FLASH) Effects at RARAF

  2020cites this paper
• MicroRNAs Responding to Space Radiation

  2020cites this paper
• Exosome-mediated radiosensitizing effect on neighboring cancer cells via reactive oxygen species production

  2020cites this paper
• Relevance of Non-Targeted Effects for Radiotherapy and Diagnostic Radiology; A Historical and Conceptual Analysis of Key Players

  2019cites this paper
• Radiation-induced bystander phenomenon: insight and implications in radiotherapy

  2019cites this paper
• On the Complexity of Mechanisms and Consequences of Chromothripsis: An Update

  2019cites this paper
• Transcriptional activation of miR-320a by ATF2, ELK1 and YY1 induces cancer cell apoptosis under ionizing radiation conditions.

  2018cites this paper
• The Ionizing Radiation-Induced Bystander Effect: Evidence, Mechanism, and Signi fi cance

  2018cites this paper
• Changes in gene expression as one of the key mechanisms involved in radiation-induced bystander effect

  2018cites this paper
• Intercellular communication of DNA damage and oxidative status underpin bystander effects

  2018cites this paper
• A review of radiation genomics: integrating patient radiation response with genomics for personalised and targeted radiation therapy

  2018cites this paper
• Uranium mining wastes: Bystander and transgenerational effects in Daphnia magna

  2017cites this paper
• 50 Years of the Radiological Research Accelerator Facility (RARAF)

  2017cites this paper
• Key mechanisms involved in ionizing radiation-induced systemic effects. A current review.

  2016cites this paper
• Exosome-Mediated Telomere Instability in Human Breast Epithelial Cancer Cells after X Irradiation

  2016cites this paper
• High throughput sequencing of small RNAs transcriptomes in two Crassostrea oysters identifies microRNAs involved in osmotic stress response

  2016cites this paper
• The Influence of Ionizing Radiation on Exosome Composition, Secretion and Intercellular Communication

  2016cites this paper
• Zebrafish as an In Vivo Model to Assess Epigenetic Effects of Ionizing Radiation

  2016cites this paper
• hsa-miR-29c and hsa-miR-135b differential expression as potential biomarker of gastric carcinogenesis.

  2016cites this paper
• Nanoparticle Based Delivery of miRNAs to Overcome Drug Resistance inBreast Cancer

  2016influential citation
• Targeted and non-targeted effects of ionizing radiation

  2015cites this paper
• Bystander effects as manifestation of intercellular communication of DNA damage and of the cellular oxidative status.

  2015cites this paper
• The non-targeted effects of radiation are perpetuated by exosomes.

  2015cites this paper
• Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects.

  2015cites this paper
• MicroRNA 29 targets nuclear factor-κB-repressing factor and Claudin 1 to increase intestinal permeability.

  2015cites this paper
• Circulating MicroRNAs as Biomarkers

  2015cites this paper
• Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies.

  2015cites this paper
• Bystander communication and cell cycle decisions after DNA damage

  2015cites this paper
• Direct and bystander radiation effects: a biophysical model and clinical perspectives.

  2015cites this paper
• The role of miR-29 family members in malignant hematopoiesis.

  2014cites this paper
• Medical radiation exposure and human carcinogenesis-genetic and epigenetic mechanisms.

  2014cites this paper
• MiR-663 inhibits radiation-induced bystander effects by targeting TGFB1 in a feedback mode

  2014cites this paper
• Radiation‐induced microRNA: Discovery, functional analysis, and cancer radiotherapy

  2014cites this paper
• Epigenetic alterations in osteosarcoma: promising targets

  2014cites this paper
• The role of TGF-β1–miR-21–ROS pathway in bystander responses induced by irradiated non-small-cell lung cancer cells

  2014cites this paper
• MiR-21 is involved in radiation-induced bystander effects

  2014cites this paper
• Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue?

  2013cites this paper
• The Ionizing Radiation-Induced Bystander Effect: Evidence, Mechanism, and Significance

  2013cites this paper
• Epigenetic Effects of Ionizing Radiation

  2013cites this paper
• Intense THz pulses cause H2AX phosphorylation and activate DNA damage response in human skin tissue

  2013cites this paper
• Novel antioxidants are not toxic to normal tissues but effectively kill cancer cells

  2013cites this paper
• Unraveling the Global microRNAome Responses to Ionizing Radiation in Human Embryonic Stem Cells

  2012influential citation
• The radiation bystander effect and its potential implications for human health.

  2012cites this paper
• Possible Role of Exosomes Containing RNA in Mediating Nontargeted Effect of Ionizing Radiation

  2012cites this paper
• miR-29b Participates in Early Aneurysm Development in Marfan Syndrome

  2012cites this paper
• Role of Epigenetic Changes in Radiation-Induced Genome Instability

  2012cites this paper
• Are Epigenetic Mechanisms Involved in Radiation-Induced Bystander Effects?

  2012cites this paper
• Non-targeted radiation effects-an epigenetic connection.

  2011cites this paper
• The role of miRNA in the direct and indirect effects of ionizing radiation

  2011cites this paper
• In vivo space radiation-induced non-targeted responses: late effects on molecular signaling in mitochondria.

  2011cites this paper
• γH2AX foci as a measure of DNA damage: a computational approach to automatic analysis.

  2011cites this paper
• RARAF PROFESSIONAL STAFF

  2008cites this paper