Regional mild hypothermia in the protection of the ischemic brain

Objetivo: Demonstrar a protecao que a hipotermia moderada pode fornecer em casos de isquemia em encefalos de coelhos. Metodos: Foi utilizado um modelo de isquemia focal em coelhos, para avaliar a protecao fornecida por meio de hipotermia moderada, produzida atraves da colocacao de pedras de gelo contidas no interior de um pequeno saco plastico, em contato com o couro cabeludo de um hemicrânio onde a tabua ossea foi previamente removida. Vinte coelhos da raca Nova Zelândia Branca, pesando de 3,100 Kg a 3,750 Kg foram divididos em dois grupos: (A) um grupo controle onde foi produzida uma lesao isquemica por meio da coagulacao da arteria cerebral media e (B) um grupo submetido a neuroprotecao por hipotermia moderada regional durante 80 a 100 minutos apos a producao da mesma lesao isquemica. As seccoes de encefalos foram coradas com 2,3,5-Tryphenyltetrazolium (TTC). As lâminas foram fotografadas com câmara digital e o volume de infarto foi calculado atraves de um programa de computador. Resultados: O volume medio de infarto foi de 70,53 mm3 no grupo controle, enquanto que o grupo com neuroprotecao apresentou media de 41,30 mm3 em 5 animais. Cinco animais deste grupo nao demonstraram macroscopica e microscopicamente areas de infarto. Conclusoes: Concluimos que a hipotermia moderada, localmente aplicada, pode proteger encefalos isquemicos de coelhos.

• Publication year

  2002

• Venue

  Acta Cirurgica Brasileira

• Publication date

  2002-08-01

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1590/S0102-86502002000400006
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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