Drug‐induced Myc‐mediated apoptosis of cancer cells is inhibited by stress protein Hsp70

No abstract is available for this paper.

• Publication year

  2007

• Venue

  International Journal of Cancer

• Publication date

  2007-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/ijc.22974PMID 17694514
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hsp70 chaperone as a survival factor in cell pathology.

  2006cited by this paper
• Specific Requirement for Bax, Not Bak, in Myc-induced Apoptosis and Tumor Suppression in Vivo*

  2006cited by this paper
• Hsp70 Inhibits Heat-induced Apoptosis Upstream of Mitochondria by Preventing Bax Translocation*

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• Hsp72 Inhibits Fas-mediated Apoptosis Upstream of the Mitochondria in Type II Cells*

  2005cited by this paper
• Lysosomes and autophagy in cell death control

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• hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

  2004cited by this paper
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  2004cited by this paper
• Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization

  2004cited by this paper
• Hsp72 Inhibits Apoptosis Upstream of the Mitochondria and Not through Interactions with Apaf-1*

  2004cited by this paper
• Differential, stage‐dependent expression of Hsp70, Hsp110 and Bcl‐2 in colorectal cancer

  2003cited by this paper
• c-myc induces autophagy in rat 3Y1 fibroblast cells.

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• Myc Potentiates Apoptosis by Stimulating Bax Activity at the Mitochondria

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• The Chaperone Function of hsp70 Is Required for Protection against Stress-Induced Apoptosis

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• Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

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• Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.

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• c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release.

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• Suppression of the Expression of Molecular Chaperones as a Factor in Increasing the Efficiency of Antitumor Therapy

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• The Role of Hsp70 in Cancer: A Study of the Hsp70 / Akt Relationship

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• Bcl-2 is a better therapeutic target than c-Myc, but attacking both could be a more effective treatment strategy for B-cell lymphoma with concurrent Bcl-2 and c-Myc overexpression.

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• Assessment of therapeutic targets in experimental models of Myc-induced lymphoma

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• Myc Is Required for Activation of the ATM-Dependent Checkpoints in Response to DNA Damage

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• The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy.

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• HSP70 and mucin 5B: novel protein targets of N,N′‐dinitrosopiperazine‐induced nasopharyngeal tumorigenesis

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