Colon-Specific Delivery of Dexamethasone from a Glucoside Prodrug in the Guinea Pig

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Pharmaceutical Research

• Publication date

  1991-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1023/A:1015838825437PMID 1871038
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Newer 5-Aminosalicylic Acid Based Drugs in Chronic Inflammatory Bowel Disease

  2012cited by this paper
• Relative anti‐inflammatory effect of oral dexamethasone‐β‐D‐glucoside and dexamethasone in experimental inflammatory bowel disease in guinea‐pigs

  1991cited by this paper
• 5 – Hydrolysis of Glycosides and Esters

  1988cited by this paper
• Measurement of gastrointestinal pH profiles in normal ambulant human subjects.

  1988cited by this paper
• The human intestinal microflora

  1986cited by this paper
• Drug glycosides: potential prodrugs for colon-specific drug delivery.

  1985cited by this paper
• Clinical Pharmacokinetics of Sulphasalazine, Its Metabolites and Other Prodrugs of 5-Aminosalicylic Acid

  1985cited by this paper
• A colon-specific drug-delivery system based on drug glycosides and the glycosidases of colonic bacteria.

  1984cited by this paper
• CHAPTER 11 – Biochemical Pharmacology and Toxicology Involving the Intestinal Flora

  1983cited by this paper
• Beclomethasone dipropionate enemas for treating inflammatory bowel disease without producing Cushing's syndrome or hypothalamic pituitary adrenal suppression.

  1982cited by this paper
• Endoscopic bipolar electrocoagulation: Development of a new bipolar coagulator for stopping gastrointestinal bleeding

  1982cited by this paper
• Anatomy of the guinea-pig cecum

  1982cited by this paper
• Response of the small intestinal mucosa to oral glucocorticoids.

  1982cited by this paper
• The normal microbial flora.

  1982cited by this paper
• BECLOMETHASONE DIPROPIONATE ENEMAS FOR TREATING INFLAMMATORY BOWEL DISEASE WITHOUT PRODUCING CUSHING'S SYNDROME OR HYPOTHALAMIC PITUITARY ADRENAL SUPRESSION

  1982cited by this paper
• 1 – First-pass metabolism within the lumen of the gastrointestinal tract

  1982cited by this paper
• Anatomy of the guinea-pig cecum.

  1982cited by this paper
• Fecalase: a model for activation of dietary glycosides to mutagens by intestinal flora.

  1980cited by this paper
• Rectally administered prednisolone--evidence for a predominantly local action.

  1980cited by this paper
• Disposition of synthetic glucocorticoids I. Pharmacokinetics of dexamethasone in healthy adults

  1979cited by this paper
• Distribution le long de l'intestin du chien des enzymes de la bordure en brosse des entérocytes

  1978cited by this paper
• Effects of prednisolone on the small intestinal mucosa of the rat.

  1976cited by this paper
• A comparison of small intestinal transit time between the rat and the guinea-pig.

  1976cited by this paper
• Human intestinal flora.

  1974cited by this paper
• Intestinal bacteria and the hydrolysis of glycosidic bonds.

  1971cited by this paper
• Carrageenan-induced ulceration of the large intestine in the guinea pig

  1971cited by this paper
• The action of sennosides and related compounds on human colon and rectum 1

  1970cited by this paper
• Cycasin Excretion in Conventional and Germfree Rats

  1966cited by this paper
• HYDROLYTIC ENZYMES OF MAMMALIAN INTESTINES. II. DISTRIBUTION OF HYDROLYTIC ENZYMES IN DOG, GUINEA-PIG, SQUIRREL, ALBINO RAT AND RABBIT INTESTINES.

  1965cited by this paper
• Glycosidases in the Mammalian Alimentary Tract

  1959cited by this paper
• Studies on the absorption of hydrocortisone from the colon of patients with idiopathic ulcerative colitis.

  1958cited by this paper
• Medical therapy in ulcerative colitis.

  1947cited by this paper

• Glucocorticoids-based prodrug design: Current strategies and research progress

  2024cites this paper
• A novel controlled release microsponges containing Albendazole against Haemonchus contortus in experimentally infected goats

  2018cites this paper
• Translating antibody directed enzyme prodrug therapy (ADEPT) and prospects for combination

  2017cites this paper
• Targeted Delivery of Drugs to Colon

  2016cites this paper
• Synthesis of Novel Hydrogels based Poly(4-Hydroxyphenylazo-3-N-(4-hydroxyphenyl)maleimide) for Specific Colon Delivery of Chemotherapeutic Agent

  2015cites this paper
• CRITICAL REVIEW IN PHARMACEUTICAL SCIENCES

  2014cites this paper
• Intestinal targeting of drugs: rational design approaches and challenges.

  2013cites this paper
• Review Article BIODEGRADABLE NATURAL POLYMERS: CARRIERS FOR COLON TARGETTING DRUG DELIVERY SYSTEM

  2013cites this paper
• Rational design and development of colon-specific prodrugs.

  2011cites this paper
• Reducing Presystemic Drug Metabolism

  2011cites this paper
• Recent trends in microbially and/or enzymatically driven colon-specific drug delivery systems.

  2011cites this paper
• Assessment of the in‐vivo drug release from pellets film‐coated with a dispersion of high amylose starch and ethylcellulose for potential colon delivery

  2010cites this paper
• 5-Fluorouracil acetic acid/beta-cyclodextrin conjugates: drug release behavior in enzymatic and rat cecal media.

  2010cites this paper
• Polysaccharides Based Colon Specific Drug delivery: A Review

  2009cites this paper
• Sulfate-conjugated methylprednisolone: Evaluation as a colon-specific methylprednisolone prodrug and comparison with sulfate-conjugated prednisolone and dexamethasone

  2009cites this paper
• Perspectives of biodegradable natural polysaccharides for site-specific drug delivery to the colon.

  2007cites this paper
• Formulation of a chitosan multi-unit dosage form for drug delivery to the colon

  2006cites this paper
• Novel drug delivery strategies for the treatment of inflammatory bowel disease

  2005cites this paper
• Polysaccharides for Colon Targeted Drug Delivery

  2004cites this paper
• The Preparation and Evaluation of Albendazole Microspheres for Colonic Delivery

  2004cites this paper
• Regional Intestinal Absorption of FITC–Dextran 4,400 with Nanoparticles Based on β-Sitosterol β-D-Glucoside in Rats

  2003cites this paper
• Regional intestinal absorption of FITC-dextran 4,400 with nanoparticles based on beta-sitosterol beta-D-glucoside in rats.

  2003cites this paper
• Colon-specific delivery of prednisolone-appended alpha-cyclodextrin conjugate: alleviation of systemic side effect after oral administration.

  2002cites this paper
• Oral delayed-release system based on Zn-pectinate gel (ZPG) microparticles as an alternative carrier to calcium pectinate beads for colonic drug delivery.

  2002cites this paper
• Delivery systems for penetration enhancement of peptide and protein drugs: design considerations.

  2001cites this paper
• Site-specific drug delivery in the gastrointestinal tract.

  2000cites this paper
• Novel oral colon-specific drug delivery systems for pharmacotherapy of peptide and nonpeptide drugs.

  1999cites this paper
• Insolubilization Test of Sodium Chondroitin Sulphate with a View to its Use as Colonic Carrier of Drugs

  1998cites this paper
• Steady‐state pharmacokinetics of corticosteroid delivery from glucuronide prodrugs in normal and colitic rats

  1997cites this paper
• [Prodrugs for colon targeting].

  1997cites this paper
• Prodrugs für das Dickdarm‐Targeting

  1997cites this paper
• Review article: older systemic and newer topical glucocorticosteroids and the gastrointestinal tract.

  1996cites this paper
• Current applications of polysaccharides in colon targeting.

  1996cites this paper
• Colonic delivery of dexamethasone from a prodrug accelerates healing of colitis in rats without adrenal suppression.

  1995cites this paper
• In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery

  1995cites this paper
• Azo polymeric hydrogels for colon targeted drug delivery.

  1995cites this paper
• Approaches and opportunities in colon-specific drug delivery.

  1995cites this paper
• Targeting of drugs and vaccines to the gut.

  1994cites this paper
• Menthol-beta-D-glucuronide: a potential prodrug for treatment of the irritable bowel syndrome.

  1994cites this paper
• Glucocorticoid-dextran conjugates as potential prodrugs for colon-specific delivery: hydrolysis in rat gastrointestinal tract contents.

  1994cites this paper
• Menthol-β-D-Glucuronide: A Potential Prodrug for Treatment of the Irritable Bowel Syndrome

  1994cites this paper
• In Vitro Evaluation of Calcium Pectinate: A Potential Colon-Specific Drug Delivery Carrier

  1993cites this paper
• In Vitro Evaluation of Dexamethasone-β-D-Glucuronide for Colon-Specific Drug Delivery

  1993cites this paper
• Enzymatic cleavage of disaccharide side groups in insoluble synthetic polymers: a new method for specific delivery of drugs to the colon.

  1993cites this paper
• Gastrointestinal parameters that influence oral medications.

  1993cites this paper
• Colonic Drug Delivery: Enhanced Release of Indomethacin from Cross-Linked Chondroitin Matrix in Rat Cecal Content

  1992cites this paper
• A Novel Prodrug of Salicylic Acid, Salicylic Acid‐glycylglycine Conjugate, Utilizing the Hydrolysis in Rabbit Intestinal Microorganisms

  1992cites this paper
• Relative anti‐inflammatory effect of oral dexamethasone‐β‐D‐glucoside and dexamethasone in experimental inflammatory bowel disease in guinea‐pigs

  1991cites this paper