Stem Cell Quiescence in the Hippocampal Neurogenic Niche Is Associated With Elevated Transforming Growth Factor-&bgr; Signaling in an Animal Model of Huntington Disease

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Neuropathology and Experimental Neurology

• Publication date

  2010-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1097/NEN.0b013e3181e4f733PMID 20535034
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Impaired Regulation of Brain Mitochondria by Extramitochondrial Ca2+ in Transgenic Huntington Disease Rats*

  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
• The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model.

  2008cited by this paper
• Rigidity in social and emotional memory in the R6/2 mouse model of Huntington's disease.

  2008cited by this paper
• Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis.

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  2008cited by this paper
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  2008cited by this paper
• Mutant α-synuclein exacerbates age-related decrease of neurogenesis

  2008cited by this paper
• TGF-beta in neural stem cells and in tumors of the central nervous system

  2007cited by this paper
• Clustering, migration, and neurite formation of neural precursor cells in the adult rat hippocampus

  2007cited by this paper
• Cellular and subcellular localization of Huntington aggregates in the brain of a rat transgenic for Huntington disease

  2007cited by this paper
• Cellular and subcellular localization of Huntingtin [corrected] aggregates in the brain of a rat transgenic for Huntington disease.

  2007cited by this paper
• Physical activity fails to rescue hippocampal neurogenesis deficits in the R6/2 mouse model of Huntington's disease.

  2007cited by this paper
• Transforming Growth Factor-&bgr;1 Is a Negative Modulator of Adult Neurogenesis

  2006cited by this paper
• Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease.

  2006cited by this paper
• A Progressive and Cell Non-Autonomous Increase in Striatal Neural Stem Cells in the Huntington's Disease R6/2 Mouse

  2006cited by this paper
• Regulation of stroke-induced neurogenesis in adult brain--recent scientific progress.

  2006cited by this paper
• Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease

  2006cited by this paper
• Chronically increased transforming growth factor-beta1 strongly inhibits hippocampal neurogenesis in aged mice.

  2006cited by this paper
• Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment

  2006cited by this paper
• The adult neural stem and progenitor cell niche is altered in amyotrophic lateral sclerosis mouse brain

  2006cited by this paper
• Abnormalities of Neurogenesis in the R6/2 Mouse Model of Huntington's Disease Are Attributable to the In Vivo Microenvironment

  2005cited by this paper
• Adult neurogenesis in the mammalian central nervous system.

  2005cited by this paper
• Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease mice.

  2005cited by this paper
• Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease.

  2005cited by this paper
• Doublecortin expression levels in adult brain reflect neurogenesis

  2005cited by this paper
• Cognitive disorders and neurogenesis deficits in Huntington's disease mice are rescued by fluoxetine

  2005cited by this paper
• Decreased hippocampal cell proliferation in R6/1 Huntington's mice

  2004cited by this paper
• Neurogenesis in a rat model of age‐related cognitive decline

  2004cited by this paper
• Neurogenesis in the striatum of the quinolinic acid lesion model of Huntington's disease.

  2004cited by this paper
• Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain

  2003cited by this paper
• SOX2 functions to maintain neural progenitor identity.

  2003cited by this paper
• Transgenic rat model of Huntington's disease.

  2003cited by this paper
• Neurogenesis in the Diseased Adult Human Brain: New Therapeutic Strategies for Neurodegenerative Diseases

  2003cited by this paper
• Increased hippocampal neurogenesis in Alzheimer's disease

  2003cited by this paper
• High Efficacy of Clonal Growth and Expansion of Adult Neural Stem Cells

  2003cited by this paper
• Disturbed spatial learning of rats after intraventricular administration of transforming growth factor-beta 1.

  2002cited by this paper
• Transforming growth factor-Beta 1 (tgf-Beta 1) in patients with amyotrophic lateral sclerosis.

  2002cited by this paper
• TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice

  2001cited by this paper
• TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

  2001cited by this paper
• Disturbed spatial learning of rats after intraventricular administration of transforming growth factor-β1

  2001cited by this paper
• Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice.

  2000cited by this paper
• CREB Phosphorylation Promotes Nerve Cell Survival

  1999cited by this paper
• TGF-beta signal transduction.

  1998cited by this paper
• TGF- SIGNAL TRANSDUCTION

  1998cited by this paper
• Cognitive manifestations of Huntington disease in relation to genetic structure and clinical onset.

  1997cited by this paper
• Analysis of cell cycle-related Ki-67 and p120 expression by flow cytometric BrdUrd-Hoechst/7AAD and immunolabeling technique.

  1997cited by this paper
• Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.

  1996cited by this paper
• Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1.

  1995cited by this paper
• A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

  1993cited by this paper
• Three‐dimensional counting: An accurate and direct method to estimate numbers of cells in sectioned material

  1988cited by this paper
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  1988cited by this paper

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  2023cites this paper
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