Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of molecular medicine

• Publication date

  2012-05-31

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s00109-012-0910-3PMID 22648519
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1983cited by this paper

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