TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells

Loss of TRAF3 results in reduced TCR signaling and defective up-regulation of T-bet and CD122 in iNKT cells that impairs their proliferation and survival.

• Publication year

  2013

• Venue

  Journal of Experimental Medicine

• Publication date

  2013-06-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20122135PMID 23650438PMCID 3674694
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Making memory at birth: understanding the differentiation of natural killer T cells.

  2012cited by this paper
• Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation

  2011cited by this paper
• Expanding TRAF function: TRAF3 as a tri-faced immune regulator

  2011cited by this paper
• IL-15 Regulates Homeostasis and Terminal Maturation of NKT Cells

  2011cited by this paper
• TNF Receptor-Associated Factor 3 Is Required for T Cell-Mediated Immunity and TCR/CD28 Signaling

  2011influential reference
• Enhanced Toll‐like receptor (TLR) responses of TNFR‐associated factor 3 (TRAF3)‐deficient B lymphocytes

  2011cited by this paper
• Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions

  2011cited by this paper
• Raising the NKT cell family

  2010cited by this paper
• Transcriptional regulation of NKT cell development and homeostasis.

  2010cited by this paper
• Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling

  2010cited by this paper
• Thymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation.

  2010cited by this paper
• Transcriptional control of invariant NKT cell development

  2010cited by this paper
• The biology of NKT cells.

  2007cited by this paper
• Control points in NKT-cell development

  2007cited by this paper
• Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs.

  2007cited by this paper
• Multiple roles of TRAF3 signaling in lymphocyte function

  2007cited by this paper
• Temporal Dissection of T-bet Functions1

  2007cited by this paper
• Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

  2006cited by this paper
• Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

  2006cited by this paper
• Signaling for NKT cell development

  2005cited by this paper
• Real-time PCR.

  2004cited by this paper
• T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells.

  2004cited by this paper
• T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn’s disease

  2004cited by this paper
• The regulatory role of Valpha14 NKT cells in innate and acquired immune response.

  2003cited by this paper
• Understanding the function of CD1-restricted T cells

  2003cited by this paper
• The Regulatory Role of Vα14 NKT Cells in Innate and Acquired Immune Response

  2003cited by this paper
• Repeated Antigen Exposure Is Necessary for the Differentiation, But Not the Initial Proliferation, of Naive CD4+ T Cells1

  2002cited by this paper
• Homeostasis of V alpha 14i NKT cells.

  2002cited by this paper
• Homeostasis of Vα14i NKT cells

  2002cited by this paper
• T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

  2002cited by this paper
• T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells.

  2001cited by this paper
• T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells

  2001cited by this paper
• A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

  2001cited by this paper
• Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.

  1996cited by this paper

• TRAF3 regulates STAT6 activation and T-helper cell differentiation by modulating the phosphatase PTP1B

  2024cites this paper
• TRAF3: Guardian of T lymphocyte functions

  2023cites this paper
• TRAF3 enhances type I interferon receptor signaling in T cells by modulating the phosphatase PTPN22

  2022cites this paper
• TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling

  2021cites this paper
• Multiple mechanisms for TRAF3-mediated regulation of the T cell costimulatory receptor GITR

  2021cites this paper
• Expansion of invariant natural killer T cells from systemic lupus erythematosus patients by alpha-Galactosylceramide and IL-15

  2021cites this paper
• TRAF family molecules in T cells: Multiple receptors and functions

  2019cites this paper
• Exome sequencing of the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease development

  2018cites this paper
• Mechanisms of TRAF3 mediated regulation of B cell survival

  2018cites this paper
• TRAF3 regulation of inhibitory signaling pathways in B and T lymphocytes by kinase and phosphatase localization

  2018cites this paper
• PDCD5 regulates iNKT cell terminal maturation and iNKT1 fate decision

  2018cites this paper
• Genetic Alterations of TRAF Proteins in Human Cancers

  2018cites this paper
• TRAF3 as a regulator of T lymphocyte activation

  2017influential citation
• TRAF Molecules in Inflammation and Inflammatory Diseases

  2017cites this paper
• TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22

  2017cites this paper
• IAP Antagonists Enhance Cytokine Production from Mouse and Human iNKT Cells

  2017cites this paper
• A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells

  2016cites this paper
• TNF Receptor Superfamily Signaling Pathways in Immune Cells

  2016cites this paper
• Burkholderia pseudomallei-derived miR-3473 enhances NF-κB via targeting TRAF3 and is associated with different inflammatory responses compared to Burkholderia thailandensis in murine macrophages

  2016cites this paper
• TRAF3 as a powerful and multitalented regulator of lymphocyte functions

  2016cites this paper
• Role of CBL-family Ubiquitin Ligases as Critical Negative Regulators of T Cell Activation and Functions

  2016cites this paper
• Targeting signaling factors for degradation, an emerging mechanism for TRAF functions

  2015cites this paper
• Roles of TRAF3 in T cells: many surprises

  2015cites this paper
• TRAF3: a novel tumor suppressor gene in macrophages.

  2015cites this paper
• Interleukin-15 enhances the expansion and function of natural killer T cells from adult peripheral and umbilical cord blood.

  2015cites this paper
• Myeloid Cell TRAF3 Regulates Immune Responses and Inhibits Inflammation and Tumor Development in Mice

  2015cites this paper
• TRAF2 regulates peripheral CD8+ T‐cell and NKT‐cell homeostasis by modulating sensitivity to IL‐15

  2015cites this paper
• Adult, but not neonatal, human lymphoid progenitors respond to TLR9 ligation by producing functional NK-like cells.

  2014cites this paper
• The adaptor molecule TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating interleukin-2 receptor signaling

  2014cites this paper
• TRAF3 Regulates Homeostasis of CD8+ Central Memory T Cells

  2014cites this paper
• The Differential Roles of mTOR, ERK, and JNK Pathways in Invariant Natural Killer T-cell Function and Survival

  2014influential citation
• Roles for TNF-receptor associated factor 3 (TRAF3) in lymphocyte functions.

  2014cites this paper
• Tumor Development in Mice Responses and Inhibits Inflammation and Myeloid Cell TRAF3 Regulates Immune

  2014cites this paper
• The Many Faces of TRAF Molecules in Immune Regulation

  2013cites this paper
• Invariant Natural Killer T Cells

  2013cites this paper