Protective immunity is induced in murine colon carcinoma cells by the expression of interleukin-12 or interleukin-18, which activate type 1 helper T cells

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Cancer Gene Therapy

• Publication date

  2000-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.cgt.7700094PMID 10770633
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Biology of Natural Killer Cells

  2008cited by this paper
• Multiple roles of interferon-gamma in the mediation of interleukin 12-induced tumor regression.

  1998cited by this paper
• IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production.

  1998cited by this paper
• IFN-gamma-inducing factor/IL-18 administration mediates IFN-gamma- and IL-12-independent antitumor effects.

  1998cited by this paper
• Vascular adhesion protein-1 and ICAM-1 support the adhesion of tumor-infiltrating lymphocytes to tumor endothelium in human hepatocellular carcinoma.

  1998cited by this paper
• Inhibition of experimental lung metastasis of murine colon carcinoma cells depends on the amount of interleukin-2 secreted from the transduced cells.

  1998cited by this paper
• A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

  1998cited by this paper
• Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis.

  1998cited by this paper
• T cell- and NK cell-independent inhibition of hepatic metastases by systemic administration of an IL-12-expressing recombinant adenovirus.

  1998cited by this paper
• Interleukin 18, a cytokine which resembles IL-1 structurally and IL-12 functionally but exerts its effect independently of both.

  1998cited by this paper
• Multiple Roles of Interferon-γ in the Mediation of Interleukin 12-induced Tumor Regression

  1998cited by this paper
• Differential capacities of CD4+, CD8+, and CD4-CD8- T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18.

  1998cited by this paper
• In vivo antitumor effects of murine interferon- γ -inducing factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma malignant ascites

  1997cited by this paper
• Antitumor effect of murine colon carcinoma cells retrovirally transduced with interleukin-4 and granulocyte macrophage-colony stimulating factor genes.

  1997cited by this paper
• Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

  1997cited by this paper
• Generation of an anti‐tumour immune response in a non‐immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1‐like profile of intratumoural cytokine expression

  1997cited by this paper
• Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production.

  1997cited by this paper
• Mouse CD1-specific NK1 T cells: development, specificity, and function.

  1997cited by this paper
• Purification and Characterization of the Human Interleukin-18 Receptor*

  1997cited by this paper
• Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression.

  1997cited by this paper
• Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors.

  1997cited by this paper
• IL-12 induces T helper 1-directed antitumor response.

  1997cited by this paper
• Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme.

  1997cited by this paper
• Requirement for Vα14 NKT Cells in IL-12-Mediated Rejection of Tumors

  1997cited by this paper
• Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

  1997cited by this paper
• Immunotherapy of experimental metastases by vaccination with interleukin gene-transduced adenocarcinoma cells sharing tumor-associated antigens. Comparison between IL-12 and IL-2 gene-transduced tumor cell vaccines.

  1996cited by this paper
• Essential requirement of an invariant V alpha 14 T cell antigen receptor expression in the development of natural killer T cells.

  1996cited by this paper
• Functional diversity of helper T lymphocytes

  1996influential reference
• Interleukin‐12 and B7.1 co‐stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors

  1996cited by this paper
• Enhanced efficacy of combination of IL-2 gene and IL-6 gene-transfected tumor cells in the treatment of established metastatic tumors.

  1996cited by this paper
• Inhibition of peritoneal dissemination of colon carcinoma in syngeneic mice immunized with interleukin-2-producing cells.

  1996cited by this paper
• Murine colon carcinoma cells engineered to produce human interleukin‐2 induce tumor‐specific anti‐tumor response

  1996cited by this paper
• Inhibition of angiogenesis in vivo by interleukin 12.

  1995cited by this paper
• Combined vaccination with major histocompatibility class I and interleukin 2 gene-transduced melanoma cells synergizes the cure of postsurgical established lung metastases.

  1995cited by this paper
• Cloning of a new cytokine that induces IFN-gamma production by T cells.

  1995cited by this paper
• Antitumor effects of interleukin-12 (IL-12): applications for the immunotherapy and gene therapy of cancer.

  1995cited by this paper
• Cloning of a new cytokine that induces IFN-γ production by T cells

  1995cited by this paper
• Construction and Characterization of Retroviral Vectors Expressing Biologically Active Human Interleukin-12

  1994cited by this paper
• Experimental and Clinical Studies of Cytokine Gene-Modified Tumor Cells

  1994cited by this paper
• Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages.

  1993cited by this paper
• Antitumor and antimetastatic activity of interleukin 12 against murine tumors

  1993cited by this paper
• Cloning and expression of murine IL-12.

  1992cited by this paper
• Sequence and structural elements that contribute to efficient encephalomyocarditis virus RNA translation

  1992cited by this paper
• Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2.

  1992cited by this paper
• Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor).

  1991cited by this paper
• The activation of IL-2 transcription in L3T4+ and Lyt-2+ lymphocytes during virus infection in vivo.

  1989cited by this paper
• Improved Retroviral Vectors for Gene Transfer and Expression

  1989cited by this paper
• Improved retroviral vectors for gene transfer and expression.

  1989cited by this paper
• Establishment of mouse colonic carcinoma cell lines with different metastatic properties.

  1980cited by this paper
• Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure.

  1975cited by this paper

• Expression Profiles of Immune Cells after Propofol or Sevoflurane Anesthesia for Colorectal Cancer Surgery: A Prospective Double-blind Randomized Trial

  2022cites this paper
• Associations between hepatocellular carcinoma risk and rs3212227 and rs568408 polymorphisms: a systematic review and meta-analysis

  2020cites this paper
• Calcium mobilizing treatment acts as a co-signal for TLR-mediated induction of Interleukin-12 (IL-12p70) secretion by murine bone marrow-derived dendritic cells.

  2017cites this paper
• Change in the immune function of porcine iliac artery endothelial cells infected with porcine circovirus type 2 and its inhibition on monocyte derived dendritic cells maturation

  2017cites this paper
• Mucosa-associated invariant T cells infiltrate hepatic metastases in patients with colorectal carcinoma but are rendered dysfunctional within and adjacent to tumor microenvironment

  2017cites this paper
• Interleukin-24 (IL-24) Expression and Biological Impact on HECV Endothelial Cells.

  2015cites this paper
• GENE THERAPY OF CANCEROUS DISEASES

  2015cites this paper
• Serum cytokine levels in patients with colorectal cancers according to tumor stages and VEGF gene polymorphism.

  2014cites this paper
• Bortezomib and IL-12 produce synergetic anti-multiple myeloma effects with reduced toxicity to natural killer cells

  2014cites this paper
• Two-dimensional Electrophoresis Combined with Mass Spectrometry Analyze the Secretory Protein Profiles in the Bifidobacterium longum XY01

  2013cites this paper
• Antitumor effects obtained by autologous Lewis lung cancer cell vaccine engineered to secrete mouse interleukin 27 by means of cationic liposome.

  2013cites this paper
• A mechanistic analysis of DNA vaccine-induced tumor immunity against the viral oncoprotein simian virus 40 large tumor antigen

  2012cites this paper
• Immunotherapeutic approach for better management of cancer--role of IL-18.

  2012cites this paper
• Double-blind Placebo-controlled Study With Interleukin-18 and Interleukin-12-encoding Plasmid DNA Shows Antitumor Effect in Metastatic Melanoma in Gray Horses

  2011cites this paper
• Measurement of Tumor Cytolysis by Macrophages

  2011influential citation
• Patients With Colorectal Cancer Are Characterized by Increased Concentration of Fecal Hb-Hp Complex, Myeloperoxidase, and Secretory IgA

  2011cites this paper
• Recombinant Human Interleukin-24 Suppresses Gastric Carcinoma Cell Growth In Vitro and In Vivo

  2010cites this paper
• Therapeutic Gene Therapy for Cancer with Interleukin-23

  2010cites this paper
• Vaccines and Immunotherapeutics for the Treatment of Malignant Disease

  2010cites this paper
• Potent antitumor efficacy of interleukin-18 delivered by conditionally replicative adenovirus vector in renal cell carcinoma-bearing nude mice via inhibition of angiogenesis

  2009cites this paper
• A DNA adjuvant encoding a fusion protein between anti‐CD3 single‐chain Fv and AIMP1 enhances T helper type 1 cell‐mediated immune responses in antigen‐sensitized mice

  2009cites this paper
• Immune killing activity of lymphocytes on Hela cells expressing interleukin-12 in vitro

  2008cites this paper
• Immune killing activity of lymphocytes on Hela cells expressing interleukin-12 in vitro

  2008cites this paper
• Effect of TGF-β1 on the expression of IL-12, IL-15, IL-18, IL-4 and IL-10 in heart transplantation rejection in rats

  2007cites this paper
• Anti-CD3 single-chain Fv/interleukin-18 fusion DNA induces anti-mycobacterial resistance via efficient interferon-gamma production in BALB/c mice infected with Mycobacterium avium.

  2006cites this paper
• The secreted form of the p40 subunit of interleukin (IL)‐12 inhibits IL‐23 functions and abrogates IL‐23‐mediated antitumour effects

  2006cites this paper
• Interleukin-12 has no effect on vascular density, perfusion, hypoxia and proliferation of an implanted human squamous cell carcinoma xenograft tumour despite up-regulation of ICAM-1.

  2005cites this paper
• Technology evaluation: SB-485232, GlaxoSmithKline.

  2005cites this paper
• Expression of IL‐27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals

  2005cites this paper
• Gene transfer of pro-IL-18 and IL-1β converting enzyme cDNA induces potent antitumor effects in L1210 cells

  2004cites this paper
• Study on interleukin-18 gene transfer into human breast cancer cells to prevent tumorigenicity

  2004cites this paper
• Serum interleukin-12 and interleukin-18 levels as a tumor marker in patients with esophageal carcinoma.

  2004cites this paper
• Bovine lactoferrin inhibits tumor‐induced angiogenesis

  2004cites this paper
• Efficient induction of T helper type 1‐mediated immune responses in antigen‐primed mice by anti‐CD3 single‐chain Fv/interleukin‐18 fusion DNA

  2004cites this paper
• Antitumor effects produced by transduction of dendritic cells-derived heterodimeric cytokine genes in murine colon carcinoma cells.

  2004cites this paper
• IL‐18 is produced by prostate cancer cells and secreted in response to interferons

  2003cites this paper
• Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor.

  2003cites this paper
• Enhanced Cytokine Synthesis of Leukocytes by a β‐Glucan Preparation, SCG, Extracted from a Medicinal Mushroom, Sparassis crispa

  2003cites this paper
• Expression of the Mig (CXCL9) gene in murine lung carcinoma cells generated angiogenesis-independent antitumor effects.

  2003cites this paper
• Cytokine-induced inflammatory liver injuries.

  2003cites this paper
• Intestinal immune responses in wild-type and Apcmin/+ mouse, a model for colon cancer.

  2003cites this paper
• Gentherapie beim Pankreaskarzinom durch adenoviralen Transfer Apoptose-induzierender und immunmodulierender Gene

  2003cites this paper
• Pathophysiological roles for IL-18 in inflammatory arthritis

  2003cites this paper
• IL-12 Regulates an Endothelial Cell-Lymphocyte Network: Effect on Metalloproteinase-9 Production1

  2003cites this paper
• Proinflammatory effects of interleukin 18

  2002cites this paper
• Leukemic dendritic cells: potential for therapy and insights towards immune escape by leukemic blasts

  2002cites this paper
• Roles of Interleukin-18 in Tissue Destruction and Compensatory Reactions

  2002cites this paper
• Secretion of interleukin-10 from murine colon carcinoma cells suppresses systemic antitumor immunity and impairs protective immunity induced against the tumors

  2002cites this paper
• Cancer gene therapy – state-of-the-art

  2002cites this paper
• Gene transfer of secreted-type modified interleukin-18 gene to B16F10 melanoma cells suppresses in vivo tumor growth through inhibition of tumor vessel formation.

  2002cites this paper
• Efficient induction of antigen-specific, T helper type 1-mediated immune responses by intramuscular injection with ovalbumin/interleukin-18 fusion DNA.

  2001cites this paper
• Implications cliniques de la production d'interleukine-18 par la muqueuse digestive

  2001cites this paper
• Intratumoral IL-18 gene transfer improves therapeutic efficacy of antibody-targeted superantigen in established murine melanoma

  2001cites this paper
• In vivo electroporation-mediated transfer of interleukin-12 and interleukin-18 genes induces significant antitumor effects against melanoma in mice

  2001cites this paper
• Vaccination with IL-18 gene-modified, superantigen-coated tumor cells elicits potent antitumor immune response

  2001cites this paper
• Tumor-Infiltrating Macrophages Induce Apoptosis in Activated CD8+ T Cells by a Mechanism Requiring Cell Contact and Mediated by Both the Cell-Associated Form of TNF and Nitric Oxide1

  2001cites this paper
• [Clinical relevance of interleukin-18 production in the intestinal mucosa].

  2001cites this paper
• Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu.

  2001cites this paper
• IL-12 Inhibition of Endothelial Cell Functions and Angiogenesis Depends on Lymphocyte-Endothelial Cell Cross-Talk1

  2001cites this paper
• Interleukin-18 regulates both Th1 and Th2 responses.

  2001cites this paper
• Interleukin 12 Secretion Enhances Antitumor Efficacy of Oncolytic Herpes Simplex Viral Therapy for Colorectal Cancer

  2001cites this paper