Effects of N-Substituted Analogs of Benztropine: Diminished Cocaine-Like Effects in Dopamine Transporter Ligands

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  2004-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1124/JPET.103.060525PMID 14755006
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Evaluation of the Blood-Brain Barrier Transport, Population Pharmacokinetics, and Brain Distribution of Benztropine Analogs and Cocaine Using in Vitro and in Vivo Techniques

  2003influential reference
• Behavioral effects of rimcazole analogues alone and in combination with cocaine.

  2003cited by this paper
• Probes for the dopamine transporter: New leads toward a cocaine‐abuse therapeutic—A focus on analogues of benztropine and rimcazole

  2002influential reference
• Self-administration of cocaine: scopolamine combinations by rhesus monkeys

  2002cited by this paper
• N-alkyl substituted analogs of the σ receptor ligand BD1008 and traditional σ receptor ligands affect cocaine-induced convulsions and lethality in mice

  2001cited by this paper
• N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice.

  2001cited by this paper
• Further studies of the reinforcing effects of benztropine analogs in rhesus monkeys

  2001influential reference
• Dopamine transporter binding without cocaine-like behavioral effects: synthesis and evaluation of benztropine analogs alone and in combination with cocaine in rodents

  2001influential reference
• Locomotor stimulant effects of novel phenyltropanes in the mouse.

  2001cited by this paper
• Differential interaction of GBR 12909, a dopamine uptake inhibitor, with cocaine and methamphetamine in rats discriminating cocaine

  2001cited by this paper
• 3’- and 4’-chloro-substituted analogs of benztropine: intravenous self-administration and in vitro radioligand binding studies in rhesus monkeys

  2000cited by this paper
• Involvement of the σ1 receptor in the cocaine‐induced conditioned place preference

  2000cited by this paper
• Involvement of the sigma1 receptor in the cocaine-induced conditioned place preference.

  2000cited by this paper
• Behavioral and neurochemical effects of the dopamine transporter ligand 4-chlorobenztropine alone and in combination with cocaine in vivo.

  1999influential reference
• Novel 3alpha-diphenylmethoxytropane analogs: selective dopamine uptake inhibitors with behavioral effects distinct from those of cocaine.

  1999influential reference
• 3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile.

  1997cited by this paper
• 3‘-Chloro-3α-(diphenylmethoxy)tropane But Not 4‘-Chloro-3α- (diphenylmethoxy)tropane Produces a Cocaine-like Behavioral Profile†

  1997cited by this paper
• Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter.

  1997influential reference
• Highly potent cocaine analogs cause long-lasting increases in locomotor activity.

  1996cited by this paper
• Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter.

  1995cited by this paper
• Novel 4'-substituted and 4',4"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors.

  1995influential reference
• Novel 3 alpha-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles.

  1994cited by this paper
• Intermediate Statistics: A Modern Approach

  1992cited by this paper
• Selective sigma ligands block stimulant effects of cocaine.

  1991cited by this paper
• The dopamine hypothesis of the reinforcing properties of cocaine.

  1991cited by this paper
• Selective σ ligands block stimulant effects of cocaine

  1991cited by this paper
• Antidepressants : neurochemical, behavioral, and clinical perspectives

  1981cited by this paper
• Effects of norcocaine and some norcocaine derivatives on schedule-controlled behavior of pigeons and squirrel monkeys.

  1979cited by this paper
• Some effects of cocaine and two cocaine analogs on schedule-controlled behavior of squirrel monkeys.

  1977cited by this paper
• Cholinergic influence on intravenous cocaine self-administration by rhesus monkeys.

  1973cited by this paper
• Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.

  1973cited by this paper
• STATISTICAL METHODS

  1967cited by this paper
• Statistical Method in Biological Assay

  1966cited by this paper
• Behavioral effects of interacting imipramine and other drugs with d-amphetamine, cocaine, and tetrabenazine

  1964cited by this paper
• Augmentation of the behavioral effects of amphetamine by atropine.

  1961influential reference

• Dopamine reuptake and inhibitory mechanisms in human dopamine transporter

  2024cites this paper
• Effects of cannabinoid agonists and antagonists in male rats discriminating the synthetic cannabinoid AM2201.

  2023cites this paper
• Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release

  2023cites this paper
• A high-affinity cocaine binding site associated with the brain acid soluble protein 1

  2022cites this paper
• New Drugs, Old Targets: Tweaking the Dopamine System to Treat Psychostimulant Use Disorders.

  2021cites this paper
• Effects of benztropine analogs on delay discounting in rats

  2020cites this paper
• Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine.

  2019cites this paper
• Identification of the benztropine analog [125I]GA II 34 binding site on the human dopamine transporter.

  2019cites this paper
• Dopamine Transporter Dynamics of N-Substituted Benztropine Analogs with Atypical Behavioral Effects

  2018cites this paper
• Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays

  2018cites this paper
• Further delineation between typical and atypical dopamine uptake inhibitors: effects on food-maintained behavior and food consumption

  2017cites this paper
• Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders.

  2017cites this paper
• The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic

  2017cites this paper
• σ Receptor Effects of N-Substituted Benztropine Analogs: Implications for Antagonism of Cocaine Self-Administration

  2017cites this paper
• Pharmacological Chaperones of the Dopamine Transporter: A Strategy for Increasing Function of Wild Type and Mutant Transporter

  2017cites this paper
• Inhibitor mechanisms in the S1 binding site of the dopamine transporter defined by multi‐site molecular tethering of photoactive cocaine analogs

  2017cites this paper
• Atypical dopamine transporter inhibitors R‐modafinil and JHW 007 differentially affect D2 autoreceptor neurotransmission and the firing rate of midbrain dopamine neurons

  2017influential citation
• DAT Conformation Does Not Predict the Ability of Atypical Dopamine Uptake Inhibitors to Substitute for Cocaine.

  2016cites this paper
• The neurochemical bases of the pharmacological activity of ligands of monoamine-transport systems

  2016cites this paper
• Stereoselective Synthesis, Structural and Spectroscopic Study of 4,5,11‐Triazatricyclo[6.2.1.0*2,6*]Undec‐5‐ene

  2016cites this paper
• 2-Substituted 3β-Aryltropane Cocaine Analogs Produce Atypical Effects without Inducing Inward-Facing Dopamine Transporter Conformations

  2016influential citation
• Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter.

  2015cites this paper
• Pharmacological Characterization of a Dopamine Transporter Ligand That Functions as a Cocaine Antagonist

  2014cites this paper
• Addiction‐Related Effects of DOV 216,303 and Cocaine: A Comparative Study in the Mouse

  2014cites this paper
• 2-Isoxazol-3-Phenyltropane Derivatives of Cocaine: Molecular and Atypical System Effects at the Dopamine Transporter

  2014cites this paper
• Preclinical Efficacy of N-Substituted Benztropine Analogs as Antagonists of Methamphetamine Self-Administration in Rats

  2014influential citation
• Role of the σRs for Development of Medications.

  2014cites this paper
• Modulation of methamphetamine's locomotor stimulation and self-administration by JHW 007, an atypical dopamine reuptake blocker.

  2014cites this paper
• Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic dopamine.

  2014cites this paper
• Dopamine transporter (DAT), nicotinic acetylcholine receptor (nAChR), and metabotropic glutamate receptor 2 (mGlu2) irreversible probes for identifying anti-psychostimulant therapeutics

  2014cites this paper
• Dopamine transporter (DAT) and metabotropic glutamate receptor 5 (MGLU5) irreversible probes for identifying anti-psychostimulant therapeutics

  2014cites this paper
• Dual dopamine/serotonin treatment approach for addictive behaviour

  2013cites this paper
• The atypical dopamine transport inhibitor, JHW 007, prevents amphetamine-induced sensitization and synaptic reorganization within the nucleus accumbens.

  2013cites this paper
• A selective dopamine reuptake inhibitor improves prefrontal cortex-dependent cognitive function: potential relevance to attention deficit hyperactivity disorder.

  2013cites this paper
• The stereotypy-inducing effects of N-substituted benztropine analogs alone and in combination with cocaine do not account for their blockade of cocaine self-administration

  2012cites this paper
• Novel C-1 Substituted Cocaine Analogs Unlike Cocaine or Benztropine

  2012cites this paper
• The binding sites for benztropines and dopamine in the dopamine transporter overlap.

  2011cites this paper
• N-Substituted Benztropine Analogs: Selective Dopamine Transporter Ligands with a Fast Onset of Action and Minimal Cocaine-Like Behavioral Effects

  2011cites this paper
• SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

  2011cites this paper
• PKC links Gq‐coupled receptors to DAT‐mediated dopamine release

  2010cites this paper
• The selective dopamine uptake inhibitor, D-84, suppresses cocaine self-administration, but does not occasion cocaine-like levels of generalization.

  2010cites this paper
• A tryptamine-derived catecholaminergic enhancer, (-)-1-(benzofuran-2-yl)-2-propylaminopentane [(-)-BPAP], attenuates reinstatement of methamphetamine-seeking behavior in rats.

  2010cites this paper
• The Novel Triple Reuptake Inhibitor JZAD-IV-22 Exhibits an Antidepressant Pharmacological Profile without Locomotor Stimulant or Sensitization Properties

  2010cites this paper
• Muscarinic Preferential M 1 Receptor Antagonists Minimally Alter the Discriminative-Stimulus Effects of Cocaine in Rats

  2010cites this paper
• Monoaminergic Psychomotor Stimulants: Discriminative Stimulus Effects and Dopamine Efflux

  2010cites this paper
• Dopamine Transporter-Dependent and -Independent Striatal Binding of the Benztropine Analog JHW 007, a Cocaine Antagonist with Low Abuse Liability

  2010cites this paper
• Positive allosteric modulation of the human cannabinoid (CB1) receptor by RTI‐371, a selective inhibitor of the dopamine transporter

  2009cites this paper
• Combinations of Cocaine with Other Dopamine Uptake Inhibitors: Assessment of Additivity

  2009influential citation
• Benzhexol-dependence resulting from self-medication for intermittent explosive disorder

  2009cites this paper
• 3D-QSAR study of 8-azabicyclo[3.2.1] octane analogs antagonists of cholinergic receptor.

  2009cites this paper
• Assessment of Reinforcing Effects of Benztropine Analogs and Their Effects on Cocaine Self-Administration in Rats: Comparisons with Monoamine Uptake Inhibitors

  2009influential citation
• Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors.

  2009influential citation
• Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters.

  2009cites this paper
• The Dopamine Uptake Inhibitor 3α-[bis(4′-fluorophenyl)metoxy]-tropane Reduces Cocaine-Induced Early-Gene Expression, Locomotor Activity, and Conditioned Reward

  2009cites this paper
• A dopamine transport inhibitor with markedly low abuse liability suppresses cocaine self-administration in the rat

  2009cites this paper
• Citalopram enhances cocaine's subjective effects in rats

  2009cites this paper
• The binding sites for cocaine and dopamine in the dopamine transporter overlap

  2008cites this paper
• Relationship between Conformational Changes in the Dopamine Transporter and Cocaine-Like Subjective Effects of Uptake Inhibitors

  2008cites this paper
• Assessment of Reinforcing Effects of Benztropine Analogues and Their Effects on Cocaine Self‐Administration: Comparisons with Monoamine Uptake Inhibitors

  2008cites this paper
• Photolabeling of the human dopamine transporter and the reactivity of aryl azides with amino acid analogs

  2008cites this paper
• Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction.

  2008cites this paper
• The novel N-substituted benztropine analog GA2-50 possesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate substitute medication for cocaine abuse.

  2008cites this paper
• Population pharmacokinetics, brain distribution, and pharmacodynamics of 2nd generation dopamine transporter selective benztropine analogs developed as potential substitute therapeutics for treatment of cocaine abuse.

  2008cites this paper
• Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys.

  2008cites this paper
• Effects of Muscarinic M1 Receptor Blockade on Cocaine-Induced Elevations of Brain Dopamine Levels and Locomotor Behavior in Rats

  2007cites this paper
• Pharmacotherapy and Treatment of Parkinson's Disease

  2007cites this paper
• Transport, Metabolism, and in Vivo Population Pharmacokinetics of the Chloro Benztropine Analogs, a Class of Compounds Extensively Evaluated in Animal Models of Drug Abuse

  2007cites this paper
• Muscarinic preferential M(1) receptor antagonists enhance the discriminative-stimulus effects of cocaine in rats.

  2007cites this paper
• Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H(1) receptors.

  2006cites this paper
• Neurotransmitter transporters: molecular function of important drug targets.

  2006cites this paper
• Relationship between in Vivo Occupancy at the Dopamine Transporter and Behavioral Effects of Cocaine, GBR 12909 [1-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine], and Benztropine Analogs

  2005cites this paper
• Assessment of the Influence of Histaminergic Actions on Cocaine-Like Effects of 3α-Diphenylmethoxytropane Analogs

  2005influential citation
• Identification of a Dopamine Transporter Ligand That Blocks the Stimulant Effects of Cocaine

  2005influential citation
• Assessment of the Influence of Histaminergic Actions on Cocaine-Like Effects of 3 (cid:1) -Diphenylmethoxytropane Analogs

  2005influential citation
• Place Conditioning and Locomotor Effects of N-Substituted, 4′,4′′-Difluorobenztropine Analogs in Rats

  2005influential citation
• Radioiodinated azide and isothiocyanate derivatives of cocaine for irreversible labeling of dopamine transporters: synthesis and covalent binding studies.

  2005cites this paper
• Effects of 4′-Chloro-3α-(diphenylmethoxy)-tropane on Mesostriatal, Mesocortical, and Mesolimbic Dopamine Transmission: Comparison with Effects of Cocaine

  2005cites this paper