The kidney as a source of blood ammonia in patients with liver disease: the effect of acetazolamide.

No abstract is available for this paper.

• Publication year

  1960

• Venue

  Journal of Clinical Investigation

• Publication date

  1960-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1172/JCI104039PMID 14429544PMCID PMC441806
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Biochemical, blood gas and peripheral circulatory alterations in hepatic coma.

  1959cited by this paper
• Non-ionic diffusion and the excretion of weak acids and bases.

  1958cited by this paper
• Peripheral biochemical changes associated with the intravenous administration of ammonium salts in normal subjects.

  1958cited by this paper
• Sites of origin and removal of blood ammonia formed during glycine infusion: effect of L-arginine.

  1958cited by this paper
• Ammonium uptake by the extremities and brain in hepatic coma.

  1958cited by this paper
• Peripheral biochemical changes associated with the intravenous administration of ammonium salts in normal subjects.

  1958cited by this paper
• A colorimetric micromethod for determination of ammonia; the ammonia content of rat tissues and human plasma.

  1957cited by this paper
• The metabolism of ammonia and alpha-keto-acids in liver disease and hepatic coma.

  1957cited by this paper
• The effects of diamox ammonia metabolism in liver disease.

  1957cited by this paper
• Production of Impending Hepatic Coma by a Carbonic Anhydrase Inhibitor, Diamox.∗ †

  1956cited by this paper
• The mechanism of the excretion of ammonia in the dog.

  1956cited by this paper
• The cerebral and peripheral uptake of ammonia in liver disease with an hypothesis for the mechanism of hepatic coma.

  1955cited by this paper
• Changes in free amino acids in the plasma during hepatic coma.

  1955cited by this paper
• Ammonium tolerance in liver disease: observations based on catheterization of the hepatic veins.

  1955cited by this paper
• Acidosis in experimental electrolyte depletion.

  1955cited by this paper
• Regulation of ammonia excretion in the rat.

  1955cited by this paper
• AMMONIA METABOLISM IN MAN

  1954cited by this paper
• Blood ammonia and electrolytes in hepatic coma.

  1953cited by this paper
• Spectrophotometric determination of blood oxygen.

  1949cited by this paper
• THE MEASUREMENT OF GLOMERULAR AND TUBULAR PLASMA FLOW IN THE NORMAL AND DISEASED HUMAN KIDNEY.

  1949cited by this paper
• Renal excretion of acid.

  1948cited by this paper
• The effect of temperature on the pH of blood and plasma in vitro.

  1948cited by this paper
• Measurement of renal blood flow.

  1948cited by this paper
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  1947cited by this paper
• THE ESTIMATION OF HEPATIC BLOOD FLOW IN MAN.

  1945cited by this paper
• Glutamine as source material of urinary ammonia.

  1943cited by this paper
• FUNCTIONAL ACTIVITY OF RENAL EPITHELIUM IN CERTAIN TYPES OF NEPHRITIS: AS INDICATED BY SECRETION OF AMMONIA

  1937cited by this paper
• STUDIES OF GAS AND ELECTROLYTE EQUILIBRIA IN BLOOD: XIII. THE DISTRIBUTION OF CHLORIDE AND BICARBONATE IN THE BLOOD OF NORMAL AND PATHOLOGICAL HUMAN SUBJECTS

  1928cited by this paper
• THE AMMONIA CONTENT OF THE BLOOD, AND ITS BEARING ON THE MECHANISM OF ACID NEUTRALIZATION IN THE ANIMAL ORGANISM

  1921cited by this paper

• Down the road towards hepatic encephalopathy. The elusive ammonia– what determines the arterial concentration?

  2024cites this paper
• Potassium deficiency decreases the capacity for urea synthesis and markedly increases ammonia in rats.

  2021cites this paper
• Studies of the blood ammonia in liver disease. Its diagnostic, prognostic, and therapeutic significance.

  2020cites this paper
• Acetazolamide Causes Renal HCO3‾ Wasting but Inhibits Ammoniagenesis and Prevents the Correction of Metabolic Acidosis by the Kidney.

  2020cites this paper
• Emerging Features of Ammonia Metabolism and Transport in Acid-Base Balance.

  2019cites this paper
• Renal Tubular Acidosis: H+/Base and Ammonia Transport Abnormalities and Clinical Syndromes.

  2018cites this paper
• Ammonia Transporters and Their Role in Acid-Base Balance.

  2017cites this paper
• Roles of renal ammonia metabolism other than in acid–base homeostasis

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• The Role of Sarcopenia and Frailty in Hepatic Encephalopathy Management.

  2015cites this paper
• Central nervous system and pulmonary complications of end‐stage liver disease

  2015cites this paper
• Pharmacotherapy for hyperammonemia

  2014cites this paper
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• Diuretics I: Physiological and Pharmacological Considerations

  2012cites this paper
• Ammonium metabolism in humans.

  2012cites this paper
• Nitric oxide and L-arginine metabolism in a devascularized porcine model of acute liver failure.

  2012cites this paper
• Cerebral metabolism during acute liver failure and the effect of treatment with fractionated plasma separation and

  2011cites this paper
• Interorgan ammonia metabolism in liver failure: the basis of current and future therapies

  2011cites this paper
• Hepatic encephalopathy: the role of inflammation, ammonia andaquaporin expression in the pathogenesis of cerebral oedema

  2010cites this paper
• The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema

  2009cites this paper
• Nitrogen metabolism and hepatocellular injury during liver resection

  2008influential citation
• The gut does not contribute to systemic ammonia release in humans without portosystemic shunting.

  2008cites this paper
• Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failure.

  2006cites this paper
• Ammonia and Hepatic Encephalopathy: The More Things Change, the More They Remain the Same

  2005cites this paper
• Renal metabolism of amino acids: its role in interorgan amino acid exchange.

  2004cites this paper
• Blood ammonia determination in cirrhosis: Still confusing after all these years?

  2003cites this paper
• The kidney plays a major role in the hyperammonemia seen after simulated or actual GI bleeding in patients with cirrhosis

  2003cites this paper
• Interorgan ammonia and amino acid metabolism in metabolically stable patients with cirrhosis and a TIPSS

  2002cites this paper
• Interorgan ammonia metabolism in liver failure.

  2002cites this paper
• Effects of high‐normal and low‐normal serum potassium levels on hepatic encephalopathy: Facts, half‐facts or artifacts?

  1994cites this paper
• The importance of renal ammonia metabolism to whole body acid-base balance: a reanalysis of the pathophysiology of renal tubular acidosis.

  1990cites this paper
• The effect of endurance training on human ammonia metabolism

  1988cites this paper
• Effect of acetazolamide on renal metabolism and ammoniagenesis in the dog.

  1987cites this paper
• Portal systemic encephalopathy (PSE).

  1987cites this paper
• Effects of carbonic anhydrase inhibition on renal ammoniagenesis in the dog.

  1986cites this paper
• [Pathogenesis of urolithiasis].

  1984cites this paper
• Carbonic Anhydrase: Pharmacology of Inhibitors and Treatment of Glaucoma

  1984cites this paper
• Acetazolamide inhibition of renal γ-glutamyl transpeptidase

  1982cites this paper
• Acetazolamide inhibition of renal gamma-glutamyl transpeptidase.

  1982cites this paper
• Ammonia partitioning between glutamine and urea: interorgan participation in metabolic acidosis.

  1981cites this paper
• Ammonia: assessment of its action on postsynaptic inhibition as a cause of convulsions.

  1980cites this paper
• What determines blood ammonia?

  1979cites this paper
• What determines blood ammonia

  1979cites this paper
• Acetazolamide and renal ammoniagenesis.

  1978cites this paper
• Parenteral nutrition in hepatic failure

  1977cites this paper
• Renal glutaminases: Diamox inhibition of glutamyltransferase.

  1975cites this paper
• [Emergency treatment of hepatic coma and porto-caval encephalopathy].

  1973cites this paper
• [Role of the kidney in the regulation of blood glutamine].

  1973cites this paper
• Defect in Urinary Acidification in Cirrhosis: The Role of Excessive Tubular Reabsorption of Sodium in Its Etiology

  1972cites this paper
• [Action of antibiotics on arterial hyperammonemia induced in liver cirrhosis patients by diuretics causing hypokalemia].

  1971cites this paper
• Potassium deficiency and endogenous ammonium overload from kidney.

  1970cites this paper
• Renal Carbonic Anhydrase and the Pharmacology of Sulfonamide Inhibitors

  1969cites this paper
• [Importance of hyperammoniemia of the renal origin in the pathogenesis of hepatic coma released in cirrhotic patients by diuretics generating hypokaliemia].

  1969cites this paper
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  1969cites this paper
• Ammoniak als Lebensmittelbestandteil und als Metabolit

  1969cites this paper
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  1969cites this paper
• [Ammonia as a food constituent and metabolite].

  1969cites this paper
• Pathogenesis of Hepatic Encephalopathy

  1968cites this paper
• Hepatogenic ascites: pathogenesis and management.

  1968cites this paper
• Renal bedingte Störungen des Säure-Basenhaushaltes

  1968cites this paper
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  1967cites this paper
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  1967cites this paper
• Pathogenesis of hepatic coma.

  1966cites this paper
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  1966cites this paper
• Renal ammonia balance. A kinetic treatment.

  1966cites this paper
• Ammonia metabolism in renal failure.

  1966cites this paper
• Renal ammonia excretion during acetazolamide or sodium bicarbonate administration.

  1966cites this paper
• Renal homeostatic mechanisms.

  1966cites this paper
• Relation of potassium depletion to renal ammonium metabolism and hepatic coma.

  1966cites this paper
• Determinants of ammonia tolerance in animals with and without portal systemic shunting.

  1966cites this paper
• [Diminution of the apparent production of ammonia by the kidney and probable augmentation of the medullar pNH3 after intravenous injection of acetazolamide in normal men].

  1965cites this paper
• THE VALUE OF AMMONIA LEVELS AS AN AID IN THE DIAGNOSIS OF URINARY EXTRAVASATION.

  1965cites this paper
• Drugs and liver disease *

  1965cites this paper
• [HYPERAMMONIEMIA OF RESPIRATORY INSUFFICIENCY].

  1964cites this paper
• THE MANAGEMENT OF HEPATIC COMA.

  1964cites this paper
• RENAL PRODUCTION AND EXCRETION OF AMMONIA.

  1964cites this paper
• THE DIAGNOSTIC VALUE OF ABDOMINAL PARACENTESIS WITH SPECIAL REFERENCE TO PERITONEAL FLUID AMMONIA LEVELS.

  1964cites this paper
• Relation of acute potassium depletion to renal ammonium metabolism in patients with cirrhosis.

  1963cites this paper
• DRUGS RELATED TO THE EXACERBATION OR AMELIORATION OF HEPATIC COMA AND THEIR EFFECTS ON AMMONIA TOXICITY.

  1963cites this paper
• Electrolyte complications of drug therapy.

  1963cites this paper
• The Use of Spironolactone and Large Doses of Steroids in the Treatment of Ascites of Liver Disease

  1963cites this paper
• THE METABOLISM OF THE VOLATILE AMINES. IV. THE ROLE OF DRUGS IN THE PATHOGENESIS OF HEPATIC ENCEPHALOPATHY.

  1963cites this paper
• Value of peritoneal fluid ammonia levels in the differential diagnosis of the acute abdomen.

  1962cites this paper
• [Respiration, acid-base equilibrium and ammonia and ammonium in the blood and cerebrospinal fluid in liver cirrhosis].

  1962cites this paper
• The effect of acute alkalosis on renal metabolism of ammonia in cirrhotics.

  1962cites this paper
• The effect of urinary output upon the excretion of ‘ammonia’ in man

  1962cites this paper
• Atmung, Säure-Basen-Gleichgewicht und Ammoniak/Ammonium in Blut und Liquor cerebrospinalis bei Lebercirrhose

  1962cites this paper
• The effect of induced hyperammonemia on renal ammonia metabolism.

  1961cites this paper
• VIII. The Effect of Acidifying Agents on Susceptibility to Infection †

  1961cites this paper
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  1961cites this paper
• The inhibition by acetazoleamide of renal phosphate-activated glutaminase in rats.

  1961cites this paper
• Current concepts in the pathogenesis and management of cirrhotic ascites.

  1961cites this paper
• [The significance of blood ammonia for the pathogenesis of hepatic coma].

  1961cites this paper
• The liver and its diseases.

  1961cites this paper
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  1960cites this paper
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  1960cites this paper
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  1960cites this paper
• Pathogenesis and treatment of hepatic failure.

  1960cites this paper