Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by reverse transcription-polymerase chain reaction analysis of IGH-MMSET fusion transcripts.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Cancer Research

• Publication date

  2000-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10945609
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 14q32 translocations and monosomy 13 observed in monoclonal gammopathy of undetermined significance delineate a multistep process for the oncogenesis of multiple myeloma. Intergroupe Francophone du Myélome.

  1999cited by this paper
• Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by double-color fluorescent in situ hybridization.

  1999cited by this paper
• Molecular analysis of 11q13 breakpoints in multiple myeloma.

  1999cited by this paper
• Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma.

  1998cited by this paper
• FGFR3 gene mutations associated with human skeletal disorders occur rarely in multiple myeloma.

  1998cited by this paper
• High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies.

  1998cited by this paper
• The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts.

  1998influential reference
• WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma.

  1998cited by this paper
• Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma

  1997cited by this paper
• Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

  1997cited by this paper
• A novel chromosomal translocation t(4; 14)(p16.3; q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene.

  1997influential reference
• The Ig heavy chain gene is frequently involved in chromosomal translocations in multiple myeloma and plasma cell leukemia as detected by in situ hybridization.

  1997cited by this paper
• Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma.

  1996cited by this paper
• Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.

  1995cited by this paper
• Structural and functional diversity in the FGF receptor multigene family.

  1993influential reference
• A cosmid contig and high resolution restriction map of the 2 megabase region containing the Huntington's disease gene

  1993cited by this paper
• A gene encoding a fibroblast growth factor receptor isolated from the Huntington disease gene region of human chromosome 4.

  1991cited by this paper
• A clinical staging system for multiple myeloma correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival

  1975cited by this paper
• R E V I E W a Rt I C L E

  year unknowncited by this paper

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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
• The proteasome component PSMD14 drives myelomagenesis through a histone deubiquitinase activity.

  2023cites this paper
• The location of the t(4;14) translocation breakpoint within the NSD2 gene identifies a subset of patients with high-risk NDMM

  2022cites this paper
• Single-cell gene fusion detection by scFusion

  2022cites this paper
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  2021cites this paper
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  2020cites this paper
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  2017cites this paper
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  2017cites this paper
• Regulatory mechanisms contributing to the homeostasis of normal and malignant hematopoietic cells

  2016cites this paper
• Severe short stature and Wolf-Hirschhorn syndrome: response to growth hormone in two cases without growth hormone deficiency

  2015cites this paper
• Gain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic intervention

  2015cites this paper
• Epigenetic Modifications in Pediatric Acute Lymphoblastic Leukemia

  2014cites this paper
• Fibroblast growth factor signaling and inhibition in non-small cell lung cancer and their role in squamous cell tumors

  2014cites this paper
• Context-specific regulation of cancer epigenomes by histone and transcription factor methylation

  2014cites this paper
• Can genome array screening replace FISH as a front‐line test in multiple myeloma?

  2014cites this paper
• Transforming acidic coiled-coil proteins (TACCs) in human cancer.

  2013cites this paper
• irrespective of FGFR3 expression In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor

  2013cites this paper
• Integrating empirical data and population genetic simulations to study the genetic architecture of type 2 diabetes

  2013cites this paper
• plasma cell tumors transition and in the intramedullary to extramedullary transition in some Possible roles for activating RAS mutations in the MGUS to MM

  2013cites this paper
• The Translocation t(4;14) Can Be Present Only in Minor Subclones in Multiple Myeloma

  2013cites this paper
• NSD2 is recruited through its PHD domain to oncogenic gene loci to drive multiple myeloma.

  2013cites this paper
• Critical signal transduction pathways in CLL.

  2013cites this paper
• significance Genomic abnormalities in monoclonal gammopathy of undetermined

  2013cites this paper
• characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients Overexpression of transcripts originating from the MMSET locus

  2013cites this paper
• TACC3 promotes epithelial-mesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways.

  2013cites this paper
• Monoclonal gammopathy of undetermined significance

  2013cites this paper
• Correction: TACC3 Is Essential for EGF-Mediated EMT in Cervical Cancer

  2013cites this paper
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  2013cites this paper
• Therapeutics , Targets , and Chemical Biology NSD 2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma

  2013cites this paper
• Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

  2013cites this paper
• role of NF- k B signaling in multiple myeloma

  2012cites this paper
• Thalidomide consolidation improves progression-free survival in myeloma with normal but not up-regulated expression of fibroblast growth factor receptor 3: analysis from the Australasian Leukaemia and Lymphoma Group MM6 clinical trial

  2012cites this paper
• Three-Dimensional Genome Architecture Influences Partner Selection for Chromosomal Translocations in Human Disease

  2012cites this paper
• Potent, Selective Inhibitors of Fibroblast Growth Factor Receptor Define Fibroblast Growth Factor Dependence in Preclinical Cancer Models

  2011cites this paper
• Comparative pre-clinical evaluation of receptor tyrosine kinase inhibitors for the treatment of multiple myeloma.

  2011cites this paper
• Plasma cell leukemia.

  2011cites this paper
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  2011cites this paper
• ) a asymptomatického mnohopočetného myelómu ( SMM )

  2011cites this paper
• Epigenetic Mechanisms in Cancer Formation and Progression

  2011cites this paper
• CD44 activation in mature B-cell malignancies by a novel recurrent IGH translocation.

  2010cites this paper
• Mieloma Múltiple: Translocaciones más importantes y sus implicaciones en el pronóstico de la enfermedad

  2010cites this paper
• The t(14;20) is a poor prognostic factor in myeloma but is associated with long-term stable disease in monoclonal gammopathies of undetermined significance

  2010cites this paper
• Anormalidades citogenéticas e sua relação com a proliferação e a apoptose celular em portadores de mieloma múltiplo

  2010cites this paper
• Identification of translocation products but not K-RAS mutations in memory B cells from patients with multiple myeloma

  2010cites this paper
• MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells

  2009cites this paper
• The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.

  2008cites this paper
• Aus dem Adolf-Butenandt-Institut für Biochemie der

  2008cites this paper
• Fibroblast Growth Factor Receptor 3 and Multiple Myeloma

  2008cites this paper
• Microfluidic chips for detecting the t(4;14) translocation and monitoring disease during treatment using reverse transcriptase-polymerase chain reaction analysis of IgH-MMSET hybrid transcripts.

  2007cites this paper
• Molecular pathogenesis of multiple myeloma.

  2007cites this paper
• Molecular characterization of human multiple myeloma cell lines by integrative genomics: Insights into the biology of the disease

  2007cites this paper
• Mitogenic signals initiated via interleukin-6 receptor complexes in cooperation with other transmembrane molecules in myelomas.

  2006cites this paper
• CHIR-258 Is Efficacious in A Newly Developed Fibroblast Growth Factor Receptor 3–Expressing Orthotopic Multiple Myeloma Model in Mice

  2006cites this paper
• MUC1 Oncoprotein Functions in Activation of Fibroblast Growth Factor Receptor Signaling

  2006cites this paper
• Mieloma múltiple quiescente: Historia natural y caracterización clínica y citogenética del tipo progresivo

  2006cites this paper
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  2006cites this paper
• Identification of ID‐1 as a potential target gene of MMSET in multiple myeloma

  2005cites this paper
• Genetics of multiple myeloma.

  2005cites this paper
• Possible roles for activating RAS mutations in the MGUS to MM transition and in the intramedullary to extramedullary transition in some plasma cell tumors.

  2005cites this paper
• Transcription repression activity is associated with the type I isoform of the MMSET gene involved in t(4;14) in multiple myeloma

  2005cites this paper
• Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients.

  2005cites this paper
• Characterization of oncogene dysregulation in multiple myeloma by combined FISH and DNA microarray analyses

  2005cites this paper
• Generation of a complete set of human telomeric band painting probes by chromosome microdissection.

  2004cites this paper
• Genetics and Cytogenetics of Multiple Myeloma

  2004cites this paper
• Genetics and Cytogenetics of Multiple Myeloma: A Workshop Report

  2004cites this paper
• A Global Expression-based Analysis of the Consequences of the t(4;14) Translocation in Myeloma

  2004cites this paper
• Heterogeneity of clonal B cells in Multiple Myeloma

  2004cites this paper
• Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma

  2004cites this paper
• Identification of a novel IGH‐MMSET fusion transcript in a human myeloma cell line with the t(4;14)(p16·3;q32) chromosomal translocation

  2004cites this paper
• Occurrence of dysregulated oncogenes in primary plasma cells representing consecutive stages of myeloma pathogenesis: indications for different disease entities

  2003cites this paper
• Usefulness of quantitative assessment of the WT1 gene transcript as a marker for minimal residual disease detection.

  2003cites this paper
• Mutation, SNP, and isoform analysis of fibroblast growth factor receptor 3 (FGFR3) in 150 newly diagnosed multiple myeloma patients.

  2003cites this paper
• In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression.

  2003cites this paper
• Genetics of Sotos syndrome

  2003cites this paper
• The Role of the SWI/SNF Component INI1 in Mammalian Development and Tumorigenesis: a Dissertation

  2003cites this paper
• A pooled analysis of karyotypic patterns, breakpoints and imbalances in 783 cytogenetically abnormal multiple myelomas reveals frequently involved chromosome segments as well as significant age‐ and sex‐related differences

  2003cites this paper
• FGF signaling inhibits the proliferation of human myeloma cells and reduces c-myc expression

  2003cites this paper
• Unsafe SETs: histone lysine methyltransferases and cancer.

  2002cites this paper
• A novel mutation involving the carboxy terminal region of the FGFR3 gene in a multiple myeloma patient with t(4;14)

  2002cites this paper
• Chromosomal and genetic abnormalities in myeloma.

  2002cites this paper
• Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation.

  2002cites this paper
• AINT/ERIC/TACC: An Expanding Family of Proteins with C-terminal Coiled Coil Domains

  2002cites this paper
• Molecular aspects of multiple myeloma

  2002cites this paper
• A molecular study of the t(4;14) in multiple myeloma

  2002cites this paper
• The biology and cytogenetics of multiple myeloma.

  2002cites this paper
• Genomic abnormalities in monoclonal gammopathy of undetermined significance.

  2002influential citation
• Myeloma clonotypic B cells are hampered in their ability to undergo B‐cell differentiation in vitro

  2002cites this paper
• FGFR3 dysregulation in multiple myeloma: frequency and prognostic relevance

  2002influential citation
• The enigma of ectopic expression of FGFR3 in multiple myeloma: a critical initiating event or just a target for mutational activation during tumor progression.

  2002cites this paper
• Atlas of Genetics and Cytogenetics in Oncology and Haematology

  2002cites this paper
• Translocations of 14q32 and deletions of 13q14 are common chromosomal abnormalities in systemic amyloidosis

  2002cites this paper
• Chromosomal and genetic abnormalities in myeloma.

  2002cites this paper
• Translocation T(4;14)(p16.3;q32) is a recurrent genetic lesion in primary amyloidosis.

  2001cites this paper
• Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14)

  2001cites this paper
• Characterization of the t(4;14)(p16.3;q32) in the KMS-18 multiple myeloma cell line

  2001cites this paper
• Biological features of the clone involved in primary amyloidosis (AL)

  2001cites this paper
• Cytogenetic, interphase, and multicolor fluorescence in situ hybridization analyses in primary plasma cell leukemia: a study of 40 patients at diagnosis, on behalf of the Intergroupe Francophone du Myélome and the Groupe Français de Cytogénétique Hématologique.

  2001cites this paper
• Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations

  2001cites this paper