Opposing roles of miR‐294 and MBNL1/2 in shaping the gene regulatory network of embryonic stem cells

No abstract is available for this paper.

• Publication year

  2018

• Venue

  EMBO Reports

• Publication date

  2018-05-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.15252/embr.201745657PMID 29735517PMCID PMC5989781
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Alternative

  2020cited by this paper
• Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors.

  2017cited by this paper
• Alternative splicing as a regulator of development and tissue identity

  2017cited by this paper
• Alternative splicing switches: Important players in cell differentiation

  2017cited by this paper
• Defective control of pre–messenger RNA splicing in human disease

  2016cited by this paper
• Pluripotency-associated miR-290/302 family of microRNAs promote the dismantling of naive pluripotency

  2016cited by this paper
• RNA splicing factors as oncoproteins and tumour suppressors

  2016cited by this paper
• MicroRNAs of the miR-290–295 Family Maintain Bivalency in Mouse Embryonic Stem Cells

  2016cited by this paper
• Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins

  2015cited by this paper
• RNA mis-splicing in disease

  2015cited by this paper
• miR‐290/371‐Mbd2‐Myc circuit regulates glycolytic metabolism to promote pluripotency

  2015influential reference
• Alternative Splicing in the Mammalian Nervous System: Recent Insights into Mechanisms and Functional Roles.

  2015cited by this paper
• Reprogramming of Polycomb-Mediated Gene Silencing in Embryonic Stem Cells by the miR-290 Family and the Methyltransferase Ash1l

  2015cited by this paper
• Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation.

  2015cited by this paper
• Towards a molecular understanding of microRNA-mediated gene silencing

  2015cited by this paper
• Mechanisms and Regulation of Alternative Pre-mRNA Splicing.

  2015cited by this paper
• Regulation of microRNA biogenesis

  2014cited by this paper
• Context-dependent control of alternative splicing by RNA-binding proteins

  2014cited by this paper
• Alternative Splicing of MBD 2 Supports Self-Renewal in Human Pluripotent Stem Cells

  2014cited by this paper
• A census of human RNA-binding proteins

  2014cited by this paper
• Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells.

  2014influential reference
• Molecular ties between the cell cycle and differentiation in embryonic stem cells

  2014cited by this paper
• Suppression of epithelial–mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells

  2014cited by this paper
• Dicer-microRNA-Myc circuit promotes transcription of hundreds of long noncoding RNAs

  2014cited by this paper
• Building robust transcriptomes with master splicing factors.

  2014cited by this paper
• MBNL proteins repress ES-cell-specific alternative splicing and reprogramming

  2013influential reference
• miR-294/miR-302 promotes proliferation, suppresses G1-S restriction point, and inhibits ESC differentiation through separable mechanisms.

  2013influential reference
• Mechanisms and models of somatic cell reprogramming

  2013cited by this paper
• Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2.

  2012cited by this paper
• DGCR8 HITS-CLIP reveals novel functions for the Microprocessor

  2012cited by this paper
• Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins.

  2012cited by this paper
• Transcriptional amplification in tumor cells with elevated c-Myc.

  2012cited by this paper
• c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells.

  2012cited by this paper
• Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells

  2011cited by this paper
• Functional consequences of developmentally regulated alternative splicing

  2011cited by this paper
• Snail and the microRNA-200 Family Act in Opposition to Regulate Epithelial-to-Mesenchymal Transition and Germ Layer Fate Restriction in Differentiating ESCs

  2011cited by this paper
• An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming.

  2011cited by this paper
• A Latent Pro-Survival Function for the Mir-290-295 Cluster in Mouse Embryonic Stem Cells

  2011cited by this paper
• Analysis and design of RNA sequencing experiments for identifying isoform regulation

  2010cited by this paper
• Integrative Modeling Defines the Nova Splicing-Regulatory Network and Its Combinatorial Controls

  2010cited by this paper
• Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation

  2010cited by this paper
• MicroRNAs: Target Recognition and Regulatory Functions

  2009cited by this paper
• Leading Edge Review RNA and Disease

  2009cited by this paper
• Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs.

  2008cited by this paper
• Embryonic Stem Cell Specific MicroRNAs Regulate the G1/S Transition and Promote Rapid Proliferation

  2008influential reference
• Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells.

  2008cited by this paper
• HITS-CLIP yields genome-wide insights into brain alternative RNA processing

  2008cited by this paper
• Tissue-specific splicing factor gene expression signatures

  2008cited by this paper
• RNA sequence analysis defines Dicer's role in mouse embryonic stem cells

  2007cited by this paper
• Diversification of stem cell molecular repertoire by alternative splicing.

  2005cited by this paper
• Variation in alternative splicing across human tissues

  2004cited by this paper
• About the authors

  2004cited by this paper
• Cluster analysis and display of genome-wide expression patterns.

  1998cited by this paper
• Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins

  year unknowncited by this paper

• The Life of MicroRNAs: Biogenesis, Function and Decay in Cancer

  2025cites this paper
• Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection

  2025cites this paper
• AGML: Adaptive Graph-Based Multi-Label Learning for Prediction of RBP and as Event Associations During EMT

  2024cites this paper
• CWF19L2 is Essential for Male Fertility and Spermatogenesis by Regulating Alternative Splicing

  2024cites this paper
• Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection

  2023cites this paper
• Evidence for Functional Roles of MicroRNAs in Lineage Specification During Mouse and Human Preimplantation Development

  2023cites this paper
• Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression

  2023cites this paper
• Alternative RNA splicing in stem cells and cancer stem cells: Importance of transcript-based expression analysis

  2021cites this paper
• MicroRNA-294 Regulates Apoptosis of the Porcine Cerebellum Caused by Selenium Deficiency via Targeting iNOS

  2021cites this paper
• Regulatory Potential of Competing Endogenous RNAs in Myotonic Dystrophies

  2021cites this paper
• The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians

  2021cites this paper
• MBNL1 Regulates the Expression and Alternative Splicing of Genes Enriched in Cell Adhesion and Apoptosis

  2021cites this paper
• MiR-290 family maintains developmental potential by targeting p21 in mouse preimplantation embryos

  2021cites this paper
• The Key Role of MicroRNAs in Self-Renewal and Differentiation of Embryonic Stem Cells

  2020cites this paper
• microRNA regulation of pluripotent state transition.

  2020cites this paper
• Intrinsic Regulatory Role of RNA Structural Arrangement in Alternative Splicing Control

  2020cites this paper
• Dgcr8 knockout approaches to understand microRNA functions in vitro and in vivo

  2019cites this paper
• Nucleoporin insufficiency disrupts a pluripotent regulatory circuit in a pro-arrhythmogenic stem cell line

  2019cites this paper
• Alternatively spliced MBNL1 isoforms exhibit differential influence on enhancing brown adipogenesis.

  2019cites this paper
• World Journal of Stem Cells

  year unknowncites this paper