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Acute and Subacute Toxicity Evaluation of Alkaloids of Peganum harmala L. in Experimental Mice

H. Guergour,R. Allouni,N. Mahdeb,A. Bouzidi

Published 2017 in Phytopathology

ABSTRACT

The objective of the study was to evaluate the acute and subacute toxicity of total alkaloids seeds of Peganum harmala in female mice. All morphological, biochemical, hematological, histopathological changes, in addition to mortality and bodyweight changes were recorded. After acute intraperitoneal administration of dose118 mg/kg, there were no any remarkable changes in general appearance and mortality. After 24h, a significant increase in relative weights of heart and brain with no change in hematological, biochemical parameter compared to the normal group. For 5 days a significant reduction in the relative weights of the kidneys and increase of brain with significant change in hematological (MCHC, MCV) and biochemical parameter (AST, ALP and Urea). Subacute study of dose (18 mg/kg) for 28 days showed no remarkable changes in general appearance and deaths occurred in experimental group. A significant increase in relative weight of brain compared to the normal group was observed. In biochemical parameters, a significant increase was seen in both ALT and AST enzyme activities. There was no significant change in hematological parameters. Histopathological examination revealed a ground glass appearance of hepatocytes and the vascular congestion. Alkaloids seeds of P.harmala showed significant toxicity in female mice.

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