Phase contrast MRI measurements of net cerebrospinal fluid flow through the cerebral aqueduct are confounded by respiration

Net cerebrospinal fluid (CSF) flow through the cerebral aqueduct may serve as a marker of CSF production in the lateral ventricles, and changes that occur with aging and in disease.

• Publication year

  2018

• Venue

  Journal of Magnetic Resonance Imaging

• Publication date

  2018-05-09

• Fields of study

  Medicine, Physics

• Identifiers
  DOI 10.1002/jmri.26181PMID 29741818PMCID 6519345
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Radiofrequency saturation induced bias in aqueductal cerebrospinal fluid flow quantification obtained using two‐dimensional cine phase contrast magnetic resonance imaging

  2018cited by this paper
• Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET

  2017cited by this paper
• Heart rate and respiration influence on macroscopic blood and CSF flows

  2017cited by this paper
• Identification of the Upward Movement of Human CSF In Vivo and its Relation to the Brain Venous System

  2017cited by this paper
• Characterization of cardiac- and respiratory-driven cerebrospinal fluid motion based on asynchronous phase-contrast magnetic resonance imaging in volunteers

  2017cited by this paper
• Role of choroid plexus in cerebrospinal fluid hydrodynamics.

  2017cited by this paper
• A change in brain white matter after shunt surgery in idiopathic normal pressure hydrocephalus: a tract-based spatial statistics study

  2017cited by this paper
• Quantifying the influence of respiration and cardiac pulsations on cerebrospinal fluid dynamics using real‐time phase‐contrast MRI

  2017cited by this paper
• Fluid and ion transfer across the blood–brain and blood–cerebrospinal fluid barriers; a comparative account of mechanisms and roles

  2016cited by this paper
• Inspiration Is the Major Regulator of Human CSF Flow

  2015cited by this paper
• CSF Flow in the Brain in the Context of Normal Pressure Hydrocephalus

  2015cited by this paper
• The Glymphatic System: A Beginner’s Guide

  2015cited by this paper
• Assessment of blood flow velocity and pulsatility in cerebral perforating arteries with 7‐T quantitative flow MRI

  2015cited by this paper
• Dynamics of respiratory and cardiac CSF motion revealed with real-time simultaneous multi-slice EPI velocity phase contrast imaging

  2015cited by this paper
• A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans.

  2015cited by this paper
• Aqueductal cerebrospinal fluid pulsatility in healthy individuals is affected by impaired cerebral venous outflow

  2014cited by this paper
• Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence

  2014cited by this paper
• Influence of respiration on cerebrospinal fluid movement using magnetic resonance spin labeling

  2013cited by this paper
• Phase contrast MRI quantification of pulsatile volumes of brain arteries, veins, and cerebrospinal fluids compartments: Repeatability and physiological interactions

  2012cited by this paper
• Phase-contrast MR studies of CSF flow rate in the cerebral aqueduct and cervical subarachnoid space with correlation-based segmentation.

  2009cited by this paper
• Magnetic resonance measurement of blood and CSF flow rates with phase contrast--normal values, repeatability and CO2 reactivity.

  2008cited by this paper
• Aging Effects on Cerebral Blood and Cerebrospinal Fluid Flows

  2007cited by this paper
• The pathophysiology of the aqueduct stroke volume in normal pressure hydrocephalus: can co-morbidity with other forms of dementia be excluded?

  2005cited by this paper
• Cerebrospinal fluid flow

  2004cited by this paper
• Relationship Between Cerebrospinal Fluid and Blood Dynamics in Healthy Volunteers and Patients with Communicating Hydrocephalus

  2004cited by this paper
• Supratentorial cerebrospinal fluid production rate in healthy adults: quantification with two-dimensional cine phase-contrast MR imaging with high temporal and spatial resolution.

  2004cited by this paper
• The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type.

  2002cited by this paper
• The Monro–Kellie hypothesis

  2001cited by this paper
• Cerebrospinal Fluid Dynamics and Relation with Blood Flow: A Magnetic Resonance Study with Semiautomated Cerebrospinal Fluid Segmentation

  2001cited by this paper
• The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer’s type

  2001cited by this paper
• Detection of a relation between respiration and CSF pulsation with an echoplanar technique

  2000cited by this paper
• Quantitative assessment of cerebrospinal fluid hydrodynamics using a phase-contrast cine MR image in hydrocephalus

  1999cited by this paper
• Cerebrospinal fluid flow and production in patients with normal pressure hydrocephalus studied by MRI

  1994cited by this paper
• MR Imaging of Cerebrospinal Fluid Dynamics in Health and Disease

  1994cited by this paper
• Cerebrospinal fluid flow measured by phase-contrast cine MR.

  1993cited by this paper
• Circadian variation in human cerebrospinal fluid production measured by magnetic resonance imaging.

  1992cited by this paper
• Cerebrospinal fluid production is reduced in healthy aging

  1990cited by this paper
• A method for MR quantification of flow velocities in blood and CSF using interleaved gradient-echo pulse sequences.

  1989cited by this paper
• Satellite radar interferometry: Two-dimensional phase unwrapping

  1988cited by this paper
• Human brain motion and cerebrospinal fluid circulation demonstrated with MR velocity imaging.

  1987cited by this paper

• Cerebrospinal Fluid-Mediated Brain Clearance: Insights from Human Studies.

  2026cites this paper
• Cerebrospinal fluid dynamics and brain function regulation: from homeostasis to neurological disorders.

  2026cites this paper
• How brain pulsations drive solute transport in the cranial subarachnoid space: insights from a toy model

  2026cites this paper
• Towards Patient Anatomy-Based Simulation of Net Cerebrospinal Fluid Flow in the Intracranial Compartment

  2026cites this paper
• Simultaneous Real-time Imaging of Neurofluid and Neurovascular Dynamics Using Ultrafast Flow-weighted Echo-Planar Imaging

  2026cites this paper
• Human cerebrospinal fluid net flow enhanced by respiration during the awake state

  2025cites this paper
• Modeling dynamic inflow effects in fMRI to quantify cerebrospinal fluid flow

  2025cites this paper
• Brain fluid physiology in ischaemic stroke; more than just oedema

  2025cites this paper
• Modeling dynamic inflow effects in fMRI to quantify cerebrospinal fluid flow

  2025cites this paper
• Assessing the feasibility of a new approach to measure the full spectrum of cerebrospinal fluid dynamics within the human brain using MRI: insights from a simulation study.

  2025cites this paper
• Simultaneous and synchronous characterization of blood and CSF flow dynamics using multiple Venc PC MRI

  2025cites this paper
• Challenging the classical view of CSF flow: measuring CSF net velocity in the human subarachnoid space with 7T MRI

  2025influential citation
• A review of cerebrospinal fluid circulation with respect to Chiari-like malformation and syringomyelia in brachycephalic dogs

  2025cites this paper
• Electroencephalogram Electrode and Amplifier Temperature Changes During Routine Anatomical and Functional Magnetic Resonance Imaging Sequences at 3 Tesla

  2025cites this paper
• Respiratory influence on cerebral blood flow and blood volume – A 4D flow MRI study

  2025cites this paper
• Measuring CSF net velocity in the human subarachnoid space with 7T MRI: testing the classical view of CSF absorption

  2025influential citation
• Cerebrospinal fluid flow and clearance driven by lateral ventricle volume oscillations

  2025cites this paper
• 3D Quantitative-Amplified Magnetic Resonance Imaging (3D q-aMRI)

  2024influential citation
• NfL concentration in CSF is a quantitative marker of the rate of neurodegeneration in aging and Huntington's disease: a semi-mechanistic model-based analysis

  2024cites this paper
• Reduced cerebrospinal fluid motion in patients with Parkinson’s disease revealed by magnetic resonance imaging with low b-value diffusion weighted imaging

  2024cites this paper
• Total cerebral blood volume changes drive macroscopic cerebrospinal fluid flux in humans

  2024cites this paper
• Clinical magnetic resonance imaging evaluation of glymphatic function

  2024cites this paper
• The impact of body position on neurofluid dynamics: present insights and advancements in imaging

  2024cites this paper
• Significant individual variation in cardiac-cycle-linked cerebrospinal fluid production following subarachnoid hemorrhage

  2024cites this paper
• [Visualization of Cerebrospinal Fluid Dynamics by Respiratory Motion Using Phase Dispersion: Optimization of Spatial and Temporal Resolutions].

  2023cites this paper
• Fluid dynamics in aging-related dementias

  2023cites this paper
• Characterising spinal cerebrospinal fluid flow in the pig with phase-contrast magnetic resonance imaging

  2023cites this paper
• Noninvasive Calculation of Cerebrospinal Fluid Production Using Phase-Contrast Magnetic Resonance Imaging: First Implementation in Augusta, Georgia

  2023cites this paper
• Four‐dimensional flow MRI for quantitative assessment of cerebrospinal fluid dynamics: Status and opportunities

  2023influential citation
• Cerebrospinal fluid turnover as a driver of brain clearance

  2023cites this paper
• Reduced suprasellar cistern cerebrospinal fluid motion in patients with Parkinson’s disease revealed by magnetic resonance imaging with dynamic cycling of diffusion weightings

  2023cites this paper
• Mechanisms of cerebrospinal fluid and brain interstitial fluid production

  2023cites this paper
• Choroid plexus vascular reactivity in moyamoya: Implications for choroid plexus regulation in ischemic stress

  2023cites this paper
• CSF circulation and dispersion yield rapid clearance from intracranial compartments

  2022cites this paper
• Coupling between cerebrovascular oscillations and CSF flow fluctuations during wakefulness: An fMRI study

  2022cites this paper
• The glymphatic hypothesis: the theory and the evidence

  2022cites this paper
• Cerebrovascular activity is a major factor in the cerebrospinal fluid flow dynamics

  2022cites this paper
• Real-Time Phase Contrast MRI to quantify Cerebral arterial flow change during variations breathing

  2022cites this paper
• Effect of Normal Breathing on the Movement of CSF in the Spinal Subarachnoid Space

  2022cites this paper
• Fluids and flows in brain cancer and neurological disorders

  2022cites this paper
• Influence of the area of the aqueduct and region of interest on quantification of stroke volume in healthy volunteers using phase-contrast cine magnetic resonance imaging

  2022cites this paper
• Choroid plexus perfusion and bulk cerebrospinal fluid flow across the adult lifespan

  2022cites this paper
• Blood and cerebrospinal fluid flow oscillations measured with real-time phase-contrast MRI: breathing mode matters

  2022influential citation
• Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies

  2022cites this paper
• of CSF in the Spinal Subarachnoid Space Effect of Normal Breathing on the Movement

  2022cites this paper
• Evaluating the Effect of Arterial Pulsation on Cerebrospinal Fluid Motion in the Sylvian Fissure of Patients with Middle Cerebral Artery Occlusion Using Low b-value Diffusion-weighted Imaging

  2021cites this paper
• Coupling brain cerebrovascular oscillations and CSF flow during wakefulness: An fMRI

  2021cites this paper
• Upright versus supine MRI: effects of body position on craniocervical CSF flow

  2021cites this paper
• Respiratory-driven Cyclic Cerebrospinal Fluid Motion in the Intracranial Cavity on Magnetic Resonance Imaging: Insights into the Pathophysiology of Neurofluid Dysfunction

  2021cites this paper
• Phase offset between arterial pulsations and subarachnoid space pressure fluctuations are unlikely to drive periarterial cerebrospinal fluid flow

  2021cites this paper
• Advanced Magnetic Resonance Imaging of the Skull Base.

  2021cites this paper
• Using deep learning convolutional neural networks to automatically perform cerebral aqueduct CSF flow analysis.

  2021cites this paper
• Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseases

  2021cites this paper
• Coupling between cerebrovascular oscillations and CSF flow fluctuation during wakefulness: An fMRI study

  2021cites this paper
• Characterization of Cardiac- and Respiratory-driven Cerebrospinal Fluid Motions Using a Correlation Mapping Technique Based on Asynchronous Two-dimensional Phase Contrast MR Imaging

  2021cites this paper
• Compressed-sensing accelerated 4D flow MRI of cerebrospinal fluid dynamics

  2020cites this paper
• Phase‐Contrast MRI Detection of Ventricular Shunt CSF Flow: Proof of Principle

  2020cites this paper
• Vascular origins of low‐frequency oscillations in the cerebrospinal fluid signal in resting‐state fMRI: Interpretation using photoplethysmography

  2020cites this paper
• Fast Phase-Contrast Cine MRI for Assessing Intracranial Hemodynamics and Cerebrospinal Fluid Dynamics

  2020cites this paper
• Longitudinal analysis of cerebral aqueduct flow measures: multiple sclerosis flow changes driven by brain atrophy

  2020cites this paper
• Real-time imaging of cerebrospinal fluid flow physiology at 7T

  2019cites this paper
• Upward movement of cerebrospinal fluid in obstructive hydrocephalus—revision of an old concept

  2019cites this paper
• Clinical Imaging of Choroid Plexus in Health and in Brain Disorders: A Mini-Review

  2019cites this paper
• Opposing CSF hydrodynamic trends found in the cerebral aqueduct and prepontine cistern following shunt treatment in patients with normal pressure hydrocephalus

  2019cites this paper
• Can pulsatile CSF flow across the cerebral aqueduct cause ventriculomegaly? A prospective study of patients with communicating hydrocephalus

  2019cites this paper
• Diffusion tensor imaging in idiopathic normal pressure hydrocephalus: clinical and CSF flowmetry correlations

  2019cites this paper
• Respiratory influence on cerebrospinal fluid flow – a computational study based on long-term intracranial pressure measurements

  2019cites this paper
• Spinal CSF flow in response to forced thoracic and abdominal respiration

  2019cites this paper
• Fluid dynamic principles for analysis of intracranial pressure control : application towards space medicine and hydrocephalus

  2019cites this paper
• “Bucket” cerebrospinal fluid bulk flow—is it a fact or a fiction?

  2018cites this paper
• Cerebrospinal fluid volumetric net flow rate and direction in idiopathic normal pressure hydrocephalus

  2018cites this paper
• Cerebrospinal fluid dynamics and brain function regulation: from homeostasis to neurological disorders

  year unknowncites this paper