Transfer of experimental allergic encephalomyelitis to bone marrow chimeras. Endothelial cells are not a restricting element

The adoptive transfer of clinical and histopathologic signs of experimental allergic encephalomyelitis (EAE) requires MHC compatibility between cell donor and cell recipient. The results of adoptive transfer studies using F1 to parent bone marrow chimeras as recipients of parental-derived BP-sensitive spleen cells indicate that this restriction is not expressed at the level of the endothelial cell but is confined to the cells of bone marrow derivation. Furthermore, these results indicate that the development of EAE is not dependent on the activity of MHC-restricted cytotoxic cells.

• Publication year

  1987

• Venue

  Journal of Experimental Medicine

• Publication date

  1987-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.166.6.1906PMID 3316476PMCID 2188803
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Retinal vascular endothelium expresses fibronectin and class II histocompatibility complex antigens in experimental autoimmune uveitis.

  1987cited by this paper
• Hyperinducibility of Ia antigen on astrocytes correlates with strain-specific susceptibility to experimental autoimmune encephalomyelitis.

  1987cited by this paper
• Interaction between myelin basic protein-sensitized T lymphocytes and murine cerebral vascular endothelial cells.

  1986cited by this paper
• Prazosin treatment suppresses increased vascular permeability in both acute and passively transferred experimental autoimmune encephalomyelitis in the Lewis rat.

  1986cited by this paper
• Prazosin treatment during the effector stage of disease suppresses experimental autoimmune encephalomyelitis in the Lewis rat.

  1986cited by this paper
• Interaction of antigen-specific T cell factors with unique "receptors" on the surface of mast cells: demonstration in vitro by an indirect rosetting technique.

  1986cited by this paper
• Characterization of inflammatory infiltrates in experimental allergic encephalomyelitis

  1986cited by this paper
• Ia expression in chronic relapsing experimental allergic encephalomyelitis induced by long-term cultured T cell lines in mice.

  1986cited by this paper
• The immunopathology of experimental allergic encephalomyelitis (EAE). III. Differential in situ expression of strain 13 Ia on endothelial and inflammatory cells of (strain 2 x strain 13)F1 guinea pigs with EAE.

  1985cited by this paper
• On the presence of Ia-positive endothelial cells and astrocytes in multiple sclerosis lesions and its relevance to antigen presentation.

  1985cited by this paper
• The immunopathology of experimental allergic encephalomyelitis. II. Endothelial cell Ia increases prior to inflammatory cell infiltration.

  1984cited by this paper
• Different mechanisms of release of vasoactive amines by mast cells occur in T cell‐dependent compared to IgE‐dependent cutaneous hypersensitivity responses

  1984cited by this paper
• Recipient contributions to serial passive transfer of experimental allergic encephalomyelitis.

  1984cited by this paper
• Modification of the clinical and histopathologic expression of experimental allergic encephalomyelitis by the vasoactive amine antagonist cyproheptadine.

  1984cited by this paper
• Delayed-type hypersensitivity: activation of mast cells by antigen-specific T-cell factors initiates the cascade of cellular interactions.

  1983cited by this paper
• T cells produce an antigen-binding factor with in vivo activity analogous to IgE antibody

  1983cited by this paper
• Vascular endothelium as a major participant in T-lymphocyte immunity.

  1982cited by this paper
• Acute experimental autoimmune encephalomyelitis in mice. I. Adjuvant action of Bordetella pertussis is due to vasoactive amine sensitization and increased vascular permeability of the central nervous system.

  1982cited by this paper
• Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species.

  1972cited by this paper
• PASSIVE TRANSFER OF ALLERGIC ENCEPHALOMYELITIS BETWEEN INBRED RAT STRAINS: CORRELATION WITH TRANSPLANTATION ANTIGENS

  1967cited by this paper

• The role of autoimmunity after traumatic brain injury

  2020cites this paper
• Cytokines and Chemokines in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

  2020cites this paper
• -Activated SJL/J Astrocytes γ Cells by IFN- T B7-1-Dependent Activation of Encephalitogenic Presentation of Proteolipid Protein Epitopes and

  2013cites this paper
• Pathology Reviews · 1989

  2011cites this paper
• Tissue-Dependent Expression of Estrogen Receptor β in 17β-Estradiol-Mediated Attenuation of Autoimmune CNS Inflammation

  2010cites this paper
• Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

  2009cites this paper
• Pathogenesis of Virus-Induced Demyelination

  2008cites this paper
• Bone marrow lacking integrin expression facilitates an enhanced susceptibility to EAE in the xenogeneic bone marrow chimeras.

  2008cites this paper
• Blood-borne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease

  2007cites this paper
• IFN-beta inhibits T cell activation capacity of central nervous system APCs.

  2006cites this paper
• IFN-β Inhibits T Cell Activation Capacity of Central Nervous System APCs1

  2006cites this paper
• APC derived from donor splenocytes support retinal autoimmune disease in allogeneic recipients

  2004influential citation
• Immune control of the brain

  2004cites this paper
• Targeting of adoptively transferred experimental allergic encephalitis lesion at the sites of Wallerian degeneration

  2004cites this paper
• Nonmyelin-Specific T Cells Accelerate Development of Central Nervous System APC and Increase Susceptibility to Experimental Autoimmune Encephalomyelitis1

  2003cites this paper
• Autoreactive T cells promote post-traumatic healing in the central nervous system.

  2003cites this paper
• De Novo Central Nervous System Processing of Myelin Antigen Is Required for the Initiation of Experimental Autoimmune Encephalomyelitis1

  2002cites this paper
• Encephalomyelitis Initiation of Experimental Autoimmune of Myelin Antigen Is Required for the De Novo Central Nervous System Processing

  2002cites this paper
• Estrogen inhibits systemic T cell expression of TNF-alpha and recruitment of TNF-alpha(+) T cells and macrophages into the CNS of mice developing experimental encephalomyelitis.

  2002cites this paper
• Estrogen Inhibits Systemic T Cell Expression of TNF-α and Recruitment of TNF-α+ T Cells and Macrophages into the CNS of Mice Developing Experimental Encephalomyelitis

  2002cites this paper
• T Lymphocytes Promote the Development of Bone Marrow-Derived APC in the Central Nervous System1

  2001cites this paper
• Astrocytes and central nervous system endothelial cells do not express B7-1 (CD80) or B7-2 (CD86) immunoreactivity during experimental autoimmune encephalomyelitis.

  2000cites this paper
• Temporal Development of Autoreactive Th1 Responses and Endogenous Presentation of Self Myelin Epitopes by Central Nervous System-Resident APCs in Theiler’s Virus-Infected Mice1

  2000cites this paper
• Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice.

  1999cites this paper
• Beta chemokine expression and regulation of lymphocyte traffic at the blood-brain barrier

  1999cites this paper
• Mechanisms of inflammation in MS tissue: adhesion molecules and chemokines.

  1999cites this paper
• [Blood-brain barrier].

  1999cites this paper
• Transfer of dendritic cells (DC) ex vivo stimulated with interferon‐gamma (IFN‐γ) down‐modulates autoimmune diabetes in non‐obese diabetic (NOD) mice

  1999cites this paper
• Antigen-presenting cells in experimental autoimmune uveoretinitis.

  1998cites this paper
• Microvascular and Cellular Responses in the Optic Nerve of Rats with Acute Experimental Allergic Encephalomyelitis (EAE)

  1998cites this paper
• Microvascular and Cellular Responses in the Retina of Rats with Acute Experimental Allergic Encephalomyelitis (EAE)

  1998cites this paper
• Microglia are more susceptible than macrophages to apoptosis in the central nervous system in experimental autoimmune encephalomyelitis through a mechanism not involving Fas (CD95).

  1998cites this paper
• J Astrocytes γ Cells by IFN-TB 7-1-Dependent Activation of Encephalitogenic Presentation of Proteolipid Protein Epitopes and and

  1998cites this paper
• Presentation of proteolipid protein epitopes and B7-1-dependent activation of encephalitogenic T cells by IFN-gamma-activated SJL/J astrocytes.

  1998cites this paper
• Characterization of and Functional Antigen Presentation by Central Nervous System Mononuclear Cells from Mice Infected with Theiler’s Murine Encephalomyelitis Virus

  1998cites this paper
• Triggers of autoimmune disease in a murine TCR-transgenic model for multiple sclerosis.

  1997cites this paper
• T-lymphocyte activation and regulation in the central nervous system.

  1997cites this paper
• Expression of major histocompatibility complex molecules in rodent retina. Immunohistochemical study.

  1997cites this paper
• Immunoneurology

  1996cites this paper
• Phenotype and function of hematopoietic‐derived cells in the CNS of SCID mouse‐lewis rat bone marrow chimeras

  1996cites this paper
• Regulation and function of central nervous system chemokines

  1995cites this paper
• Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared.

  1995cites this paper
• Encephalitogenic T lymphocytes develop from SJL/J hematopoietic cells transplanted into severe combined immunodeficient (SCID) mice.

  1995cites this paper
• Strain-specific variation in constitutive and inducible expression of MHC class II, class I and ICAM-1 on rat cerebral endothelium.

  1994cites this paper
• Do Chemokines Mediate Inflammatory Cell Invasion of the Central Nervous System Parenchyma?

  1994cites this paper
• Lysis of rat brain microvascular endothelial cells mediated by resting but not activated MBP-specific CD4+ T cell lines.

  1994cites this paper
• Towards T cell vaccination in rheumatoid arthritis.

  1994cites this paper
• Immunity to T cell receptor peptides: theory and applications.

  1994cites this paper
• Cell Adhesion Molecules: Novel Therapeutic Targets for Chronic Inflammatory Diseases of the Central Nervous System

  1994cites this paper
• In vivo antigen presentation by both brain parenchymal cells and hematopoietically derived cells during the induction of experimental autoimmune encephalomyelitis.

  1993cites this paper
• Interferon-gamma-inducible endothelial cell class II major histocompatibility complex expression correlates with strain- and site-specific susceptibility to experimental allergic encephalomyelitis.

  1993cites this paper
• Magnetic resonance imaging investigation of blood-brain barrier damage in adoptive transfer experimental autoimmune encephalomyelitis.

  1993cites this paper
• Cellular basis of T-cell autoreactivity in autoimmune diseases

  1993cites this paper
• Homing of T cells to the central nervous system throughout the course of relapsing experimental autoimmune encephalomyelitis in Thy-1 congenic mice.

  1993cites this paper
• Interferon-γ-inducible endothelial cell class II major histocompatibility complex expression correlates with strain- and site-specific susceptibility to experimental allergic encephalomyelitis

  1993cites this paper
• Induction of experimental autoimmune encephalomyelitis in severe combined immunodeficient mice reconstituted with allogeneic or xenogeneic hematopoietic cells.

  1993cites this paper
• Selective localisation of neuro-specific T lymphocytes in the central nervous system.

  1992cites this paper
• Observations, legends, and conjectures concerning restricted T-cell receptor usage and autoimmune disease.

  1992cites this paper
• Autoimmune inflammation of astrocyte transplants

  1992cites this paper
• Myelin specific, autoaggressive T cell clones in the normal immune repertoire: their nature and their regulation.

  1992cites this paper
• Delayed-type hypersensitivity recruitment of T cell subsets via antigen-specific non-IgE factors or IgE antibodies: relevance to asthma, autoimmunity and immune responses to tumors and parasites.

  1992cites this paper
• Preferential increase of IL-2R+ CD4+ T cells and CD45RB- CD4+ T cells in the central nervous system in experimental allergic encephalomyelitis.

  1992cites this paper
• Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system.

  1991cites this paper
• Interactions between endothelial cells and the cells of the immune system.

  1991cites this paper
• Prevention of Insulitis and Diabetes Onset by Treatment With Complete Freund's Adjuvant in NOD Mice

  1991cites this paper
• Migration of Hematogenous Cells Through the Blood‐Brain Barrier and the Initiation of CNS Inflammation

  1991cites this paper
• The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneously diabetic mice.

  1991cites this paper
• Specificity of human T cell clones reactive to immunodominant epitopes of myelin basic protein

  1991cites this paper
• Haplotype-specific inhibition of homing of radiolabeled lymphocytes in experimental allergic encephalomyelitis following treatment with anti-IA antibodies.

  1991cites this paper
• Immunologic interactions of T lymphocytes with vascular endothelium.

  1991cites this paper
• Inflammation in the nervous system. Basic mechanisms and immunological concepts.

  1991cites this paper
• Hypothesis: Antigen-specific T cells prime central nervous system endothelium for recruitment of nonspecific inflammatory cells to effect autoimmune demyelination

  1991cites this paper
• Immune function of the blood-brain barrier: incomplete presentation of protein (auto-)antigens by rat brain microvascular endothelium in vitro

  1990cites this paper
• Antigen-specific damage to brain vascular endothelial cells mediated by encephalitogenic and nonencephalitogenic CD4+ T cell lines in vitro.

  1990cites this paper
• Phosphosugars are potent inhibitors of central nervous system inflammation 1

  1989cites this paper
• Syngeneic t cell transfer of diabetes into nod newborn mice: in situ studies of the autoimmune steps leading to insulin‐producing cell destruction

  1989cites this paper
• The Role of Islet Transplantation in the Treatment of Insulin-dependent Diabetes Mellitus

  1989cites this paper
• The role of mast cells in the elicitation of experimental allergic encephalomyelitis.

  1989cites this paper
• In situ Ia expression on brain cells in the rat: autoimmune encephalomyelitis-resistant strain (BN) and susceptible strain (Lewis) compared.

  1989cites this paper
• Hepatic homing of mononuclear inflammatory cells isolated during murine chronic graft-vs-host disease.

  1989cites this paper
• Expression and Cellular Localization of Major Histocompatibility Complex Antigens in Active Multiple Sclerosis Lesions a

  1988cites this paper
• Role of T helper lymphocytes in autoimmune diseases.

  1988cites this paper
• Intercellular interactions in myelin-specific autoimmunity.

  1988cites this paper