Runx1 promotes B-cell survival and lymphoma development.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Blood Cells, Molecules & Diseases

• Publication date

  2009-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bcmd.2009.01.013PMID 19269865
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Conditional expression and oncogenicity of c‐myc linked to a CD2 gene dominant control region

  2009cited by this paper
• Gatekeeper function of the RUNX1 transcription factor in acute leukemia.

  2008cited by this paper
• Utilization of pathway signatures to reveal distinct types of B lymphoma in the Emicro-myc model and human diffuse large B-cell lymphoma.

  2008cited by this paper
• Gene array analysis reveals a common Runx transcriptional programme controlling cell adhesion and survival

  2008cited by this paper
• AML1/RUNX1 Works as a Negative Regulator of c-Mpl in Hematopoietic Stem Cells*

  2008cited by this paper
• Runx Expression Is Mitogenic and Mutually Linked to Wnt Activity in Blastula-Stage Sea Urchin Embryos

  2008cited by this paper
• TEL-AML1 preleukemic activity requires the DNA binding domain of AML1 and the dimerization and corepressor binding domains of TEL

  2007cited by this paper
• Five distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemia

  2007cited by this paper
• Isoform-Specific Potentiation of Stem and Progenitor Cell Engraftment by AML1/RUNX1

  2007cited by this paper
• The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells

  2007cited by this paper
• The multi-functional cellular adhesion molecule CD44 is regulated by the 8;21 chromosomal translocation

  2007cited by this paper
• Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo.

  2006cited by this paper
• Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21.

  2006cited by this paper
• AML1 deletion in adult mice causes splenomegaly and lymphomas

  2006cited by this paper
• Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm‐deficient mice

  2006cited by this paper
• Reduction of Runx1 Transcription Factor Activity Up-Regulates Fas and Bim Expression and Enhances the Apoptotic Sensitivity of Double Positive Thymocytes1

  2005cited by this paper
• Role for Runx1 in the Proliferation and Neuronal Differentiation of Selected Progenitor Cells in the Mammalian Nervous System

  2005cited by this paper
• Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice

  2005cited by this paper
• Functional Domains of Runx1 Are Differentially Required for CD4 Repression, TCRβ Expression, and CD4/8 Double-Negative to CD4/8 Double-Positive Transition in Thymocyte Development1

  2005cited by this paper
• Regulation of skeletal development by the Runx family of transcription factors

  2005cited by this paper
• The runx genes: gain or loss of function in cancer

  2005cited by this paper
• The Bone-specific Expression of Runx2 Oscillates during the Cell Cycle to Support a G1-related Antiproliferative Function in Osteoblasts*

  2005cited by this paper
• Localization of the Domains in Runx Transcription Factors Required for the Repression of CD4 in Thymocytes1

  2004cited by this paper
• Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression.

  2004cited by this paper
• Regulation of TGFβ1-mediated growth inhibition and apoptosis by RUNX2 isoforms in endothelial cells

  2004cited by this paper
• RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53

  2004cited by this paper
• AML1/RUNX1 Increases During G1 to S Cell Cycle Progression Independent of Cytokine-dependent Phosphorylation and Induces Cyclin D3 Gene Expression*

  2004cited by this paper
• Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.

  2004cited by this paper
• AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

  2004cited by this paper
• Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia.

  2004cited by this paper
• Runx1 Is Expressed in Adult Mouse Hematopoietic Stem Cells and Differentiating Myeloid and Lymphoid Cells, But Not in Maturing Erythroid Cells

  2004cited by this paper
• Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma.

  2004cited by this paper
• Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis.

  2003cited by this paper
• The Runx genes as dominant oncogenes.

  2003cited by this paper
• Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

  2003cited by this paper
• Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases

  2003cited by this paper
• The role of a Runt domain transcription factor AML1/RUNX1 in leukemogenesis and its clinical implications.

  2003cited by this paper
• Role of AML1/Runx1 in the pathogenesis of hematological malignancies

  2003cited by this paper
• Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts.

  2003cited by this paper
• RUNX/AML and C/EBP factors regulate CD11a integrin expression in myeloid cells through overlapping regulatory elements.

  2003cited by this paper
• Upstream and downstream targets of RUNX proteins

  2003cited by this paper
• New genes involved in cancer identified by retroviral tagging

  2002cited by this paper
• High-throughput retroviral tagging to identify components of specific signaling pathways in cancer

  2002cited by this paper
• The Common Retroviral Insertion Locus Dsi1 Maps 30 Kilobases Upstream of the P1 Promoter of the Murine Runx3/Cbfa3/Aml2 Gene

  2002cited by this paper
• Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma.

  2002cited by this paper
• AML1 gene over-expression in childhood acute lymphoblastic leukemia

  2002cited by this paper
• Expression of myeloid-specific genes in childhood acute lymphoblastic leukemia – a cDNA array study

  2002cited by this paper
• Core-binding factors in haematopoiesis and leukaemia

  2002cited by this paper
• Enforced Expression of Runx2 Perturbs T Cell Development at a Stage Coincident with β-Selection1

  2002cited by this paper
• Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis

  2002cited by this paper
• Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

  2002cited by this paper
• Overexpression of AML1 Transcription Factor Drives Thymocytes into the CD8 Single-Positive Lineage1

  2001cited by this paper
• High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2 alpha B gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21.

  2000cited by this paper
• High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2αB gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21

  2000cited by this paper
• Expression of the AML-1 Oncogene Shortens the G1Phase of the Cell Cycle*

  2000cited by this paper
• Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.

  2000cited by this paper
• Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector

  1999cited by this paper
• Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias.

  1999cited by this paper
• A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with MYC

  1999cited by this paper
• Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

  1999cited by this paper
• Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment.

  1999cited by this paper
• Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

  1998cited by this paper
• Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow.

  1998cited by this paper
• Overexpression of AML1 renders a T hybridoma resistant to T cell receptor-mediated apoptosis

  1998cited by this paper
• Acute lymphoblastic leukemia and chromosome 21.

  1997cited by this paper
• Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene.

  1997cited by this paper
• The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

  1996cited by this paper
• AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.

  1996cited by this paper
• Apparent bypass of negative selection in CD8+ tumours in CD2-myc transgenic mice.

  1996cited by this paper
• til-1: a novel proviral insertion locus for Moloney murine leukaemia virus in lymphomas of CD2-myc transgenic mice.

  1996cited by this paper
• Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

  1996cited by this paper
• IgH enhancer deregulated expression of L‐myc: abnormal T lymphocyte development and T cell lymphomagenesis.

  1990cited by this paper
• Strain dependency of B and T lymphoma development in immunoglobulin heavy chain enhancer (E mu)-myc transgenic mice

  1989cited by this paper
• Genetic studies on Emu-myc transgenic mice.

  1988cited by this paper
• Manipulating the mouse embryo: A laboratory manual

  1986cited by this paper
• The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

  1985cited by this paper

• scTELL: a single-cell ATAC-seq tool for locus-specific transposable element identification in chromatin accessibility.

  2026cites this paper
• MYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by suppressing RUNX1 transcription

  2024cites this paper
• Single-cell biological network inference using a heterogeneous graph transformer

  2023cites this paper
• Runx1 Deficiency Promotes M2 Macrophage Polarization Through Enhancing STAT6 Phosphorylation

  2023cites this paper
• NONO regulates B‐cell development and B‐cell receptor signaling

  2023cites this paper
• Oncogenic Runx1-Myc axis in p53-deficient thymic lymphoma.

  2022cites this paper
• DeepMAPS: Single-cell biological network inference using heterogeneous graph

  2021cites this paper
• Reduction of RUNX1 transcription factor activity by a CBFA2T3-mimicking peptide: application to B cell precursor acute lymphoblastic leukemia

  2021cites this paper
• RUNX1 Is a Driver of Renal Cell Carcinoma Correlating with Clinical Outcome

  2020cites this paper
• A Novel AP2/ERF Transcription Factor, OsRPH1, Negatively Regulates Plant Height in Rice

  2020cites this paper
• Collaboration of MYC and RUNX2 in lymphoma simulates T‐cell receptor signaling and attenuates p53 pathway activity

  2019cites this paper
• Interrogation of human hematopoiesis at single-cell and single-variant resolution

  2018cites this paper
• Genetic alterations crossing the borders of distinct hematopoetic lineages and solid tumors: Diagnostic challenges in the era of high-throughput sequencing in hemato-oncology.

  2018cites this paper
• Runx3 in Immunity, Inflammation and Cancer.

  2017cites this paper
• RUNX‐mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins

  2017cites this paper
• Control of RUNX-induced repression of Notch signaling by MLF and its partner DnaJ-1 during Drosophila hematopoiesis

  2017cites this paper
• Relationship between RUNX1 and AXIN1 in ER-negative versus ER-positive Breast Cancer

  2017cites this paper
• The RUNX Genes as Conditional Oncogenes: Insights from Retroviral Targeting and Mouse Models.

  2017cites this paper
• Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines

  2017cites this paper
• Runx1 Orchestrates Sphingolipid Metabolism and Glucocorticoid Resistance in Lymphomagenesis

  2017cites this paper
• RUNX transcription factors at the interface of stem cells and cancer.

  2017cites this paper
• Roles of RUNX in B Cell Immortalisation.

  2017cites this paper
• asthma and modulated by maternal smoking RUNX transcription factors: association with pediatric

  2016cites this paper
• Addiction to Runx1 is partially attenuated by loss of p53 in the Eμ-Myc lymphoma model

  2016cites this paper
• Quantifying deleterious effects of regulatory variants

  2016cites this paper
• Core binding factor (CBF) is required for Epstein-Barr virus EBNA3 proteins to regulate target gene expression

  2016cites this paper
• Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 expression in hematopoietic cells

  2015cites this paper
• Rôle des protéines AID et Bfl-1 dans les processus d'instabilité génomique et de survie cellulaire induits par l'oncoprotéine Tax au cours de la lymphomagénèse associée à l'infection par HTLV-1

  2014cites this paper
• RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland

  2014cites this paper
• The emerging role of Twist proteins in hematopoietic cells and hematological malignancies

  2014cites this paper
• Aberrant DNA methylation and epigenetic inactivation of hMSH2 decrease overall survival of acute lymphoblastic leukemia patients via modulating cell cycle and apoptosis.

  2014cites this paper
• Insertional Mutagenesis and Deep Profiling Reveals Gene Hierarchies and a Myc/p53-Dependent Bottleneck in Lymphomagenesis

  2014cites this paper
• The emerging role of Twist proteins in hematopoietic cells and hematological malignancies

  2014cites this paper
• RUNX 2 correlates with subtype-specific breast cancer in a human tissue microarray , and ectopic expression of Runx 2 perturbs differentiation in the mouse mammary gland

  2014cites this paper
• B-lineage transcription factors and cooperating gene lesions required for leukemia development

  2013cites this paper
• CEH-20/Pbx and UNC-62/Meis function upstream of rnt-1/Runx to regulate asymmetric divisions of the C. elegans stem-like seam cells

  2013cites this paper
• Runx Transcription Factors Repress Human and Murine c-Myc Expression in a DNA-Binding and C-Terminally Dependent Manner

  2013cites this paper
• RUNX2 in mammary gland development and breast cancer

  2013cites this paper
• The RUNX family in breast cancer: relationships with estrogen signaling

  2013cites this paper
• A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiation.

  2013cites this paper
• ELUCIDATING REGULATORY NETWORKS PROMOTING B-CELL DEVELOPMENT

  2012cites this paper
• Confirmation of a Mutation by Multiple Molecular Approaches

  2012cites this paper
• Epigenetic inactivation of TWIST2 in acute lymphoblastic leukemia modulates proliferation, cell survival and chemosensitivity

  2012cites this paper
• Runx1 C-terminal Domains During Hematopoietic Development and Leukemogenesis: A Dissertation

  2012cites this paper
• RUNX transcription factors: association with pediatric asthma and modulated by maternal smoking.

  2011cites this paper
• Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progression

  2010cites this paper
• Over‐expression of Runx1 transcription factor impairs the development of thymocytes from the double‐negative to double‐positive stages

  2010cites this paper
• Downregulation of RUNX1 by RUNX3 Requires the RUNX3 VWRPY Sequence and Is Essential for Epstein-Barr Virus-Driven B-Cell Proliferation

  2009cites this paper
• RUNX3‐mediated repression of RUNX1 in B cells

  2009cites this paper