Structural studies of crystalline forms of triamterene with carboxylic acid, GRAS and API molecules

This work discusses the preparation and characterization of crystalline forms of the drug triamterene with various carboxylic acids including Generally Regarded as Safe and Active Pharmaceutical Ingredients using liquid-assisted grinding and solvent-evaporative crystallization; a method of potential benefit to the pharmaceutical industry. Triamterene is selected as an appropriate model compound because it has poor water solubility which can have an impact on its bioavailability as a drug and it contains numerous hydrogen-bonding sites, thereby allowing a study of the competition between the different potential supramolecular synthons. Cambridge Structural Database studies show good agreement between this and previous studies using similar compounds.

• Publication year

  2018

• Venue

  IUCrJ

• Publication date

  2018-04-06

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1107/S2052252518003317PMID 29755747PMCID 5929377
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Saint

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