Hypoxia-Inducible Factors (HIFs) in the articular cartilage: a systematic review.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  European Review for Medical and Pharmacological Sciences

• Publication date

  2017-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 28682438
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hypoxia-inducible factor 3 biology: complexities and emerging themes.

  2016cited by this paper
• SKELETAL BIOLOGYAND REGULATION ( MR FORWOOD AND A ROBLING , SECTION EDITORS ) Osteoblast-Chondrocyte Interactions in Osteoarthritis

  2016cited by this paper
• Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration.

  2016cited by this paper
• Chondrocytes, Mesenchymal Stem Cells, and Their Combination in Articular Cartilage Regenerative Medicine

  2016cited by this paper
• Hypoxia-inducible factor-2α induces expression of type X collagen and matrix metalloproteinases 13 in osteoarthritic meniscal cells

  2016cited by this paper
• Intra‐articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF‐2α

  2015cited by this paper
• Hypoxia‐inducible factor 3‐alpha expression is associated with the stable chondrocyte phenotype

  2015cited by this paper
• Role of HIF-1α and HIF-2α in osteoarthritis.

  2015cited by this paper
• Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review).

  2015cited by this paper
• Polymorphic variation of hypoxia inducible factor-1 A (HIF1A) gene might contribute to the development of knee osteoarthritis: a pilot study

  2015cited by this paper
• PHDs inhibitor DMOG promotes the vascularization process in the AV loop by HIF-1a up-regulation and the preliminary discussion on its kinetics in rat

  2014cited by this paper
• A Gain-of-Function Mutation in Tnni2 Impeded Bone Development through Increasing Hif3a Expression in DA2B Mice

  2014cited by this paper
• Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia.

  2014cited by this paper
• Caudal Regulates the Spatiotemporal Dynamics of Pair-Rule Waves in Tribolium

  2014cited by this paper
• Signaling Pathways in Cartilage Repair

  2014cited by this paper
• Extracellular matrix production in vitro in cartilage tissue engineering

  2014cited by this paper
• The Hypoxia-Inducible Factor Pathway, Prolyl Hydroxylase Domain Protein Inhibitors, and Their Roles in Bone Repair and Regeneration

  2014cited by this paper
• Toward regeneration of articular cartilage.

  2013cited by this paper
• A hypoxia-inducible factor (HIF)-3α splicing variant, HIF-3α4 impairs angiogenesis in hypervascular malignant meningiomas with epigenetically silenced HIF-3α4.

  2013cited by this paper
• Simvastatin treatment inhibits hypoxia inducible factor 1-alpha-(HIF-1alpha)-prolyl-4-hydroxylase 3 (PHD-3) and increases angiogenesis after myocardial infarction in streptozotocin-induced diabetic rat.

  2013cited by this paper
• PHD4 Stimulates Tumor Angiogenesis in Osteosarcoma Cells via TGF-α

  2013cited by this paper
• Insights on biology and pathology of HIF-1α/-2α, TGFβ/BMP, Wnt/β-catenin, and NF-κB pathways in osteoarthritis.

  2012cited by this paper
• HIF-3α mRNA expression changes in different tissues and their role in adaptation to intermittent hypoxia and physical exercise.

  2012cited by this paper
• Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors.

  2012cited by this paper
• Effects of oxygen and culture system on in vitro propagation and redifferentiation of osteoarthritic human articular chondrocytes

  2012cited by this paper
• Regulation of hypoxia-inducible factor-1α (HIF-1α) expression by interleukin-1β (IL-1β), insulin-like growth factors I (IGF-I) and II (IGF-II) in human osteoarthritic chondrocytes

  2012cited by this paper
• Osteoarthritis year 2012 in review: biology.

  2012cited by this paper
• Molecular characterization and expression analysis of three hypoxia-inducible factor alpha subunits, HIF-1α/2α/3α of the hypoxia-sensitive freshwater species, Chinese sucker.

  2012cited by this paper
• Passing the baton: the HIF switch.

  2012cited by this paper
• HIF-1 versus HIF-2--is one more important than the other?

  2012cited by this paper
• A large‐scale replication study for the association of rs17039192 in HIF‐2α with knee osteoarthritis

  2012cited by this paper
• Hypoxia-inducible factor-1 is a positive regulator of Sox9 activity in femoral head osteonecrosis.

  2011cited by this paper
• Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development

  2011cited by this paper
• Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction

  2011cited by this paper
• Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

  2011cited by this paper
• Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice.

  2011cited by this paper
• HIF-2α as a possible therapeutic target of osteoarthritis.

  2010cited by this paper
• Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

  2010cited by this paper
• Anabolic and catabolic responses of human articular chondrocytes to varying oxygen percentages

  2010cited by this paper
• HIF-2α - a mediator of osteoarthritis?

  2010cited by this paper
• Shifting HIFs in osteoarthritis

  2010cited by this paper
• Hypoxia-inducible factor (HIF)-3alpha is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2.

  2010cited by this paper
• Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

  2010cited by this paper
• Prolyl Hydroxylases and Therapeutics

  2010cited by this paper
• HIF-1 and HIF-2 transcription factors — Similar but not identical

  2010cited by this paper
• Regulation of HIF-1alpha at the transcriptional level.

  2009cited by this paper
• Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy.

  2009cited by this paper
• Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement

  2009cited by this paper
• The Basic Science of Articular Cartilage

  2009cited by this paper
• Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair

  2009cited by this paper
• The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction.

  2009cited by this paper
• Immobilization-Induced Cartilage Degeneration Mediated Through Expression of Hypoxia-Inducible Factor-1α, Vascular Endothelial Growth Factor, and Chondromodulin-I

  2009cited by this paper
• The Physiology and Pathophysiology of the Hyperbaric and Diving Environments Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo

  2009cited by this paper
• Activation of the hypoxia-inducible factor-1α pathway accelerates bone regeneration

  2008cited by this paper
• Role of hypoxia-inducible factor 1alpha in the integrity of articular cartilage in murine knee joints

  2008cited by this paper
• Biology of hypoxia-inducible factor-2α in development and disease

  2008cited by this paper
• Non-hypoxic induction of HIF-3alpha by 2-deoxy-D-glucose and insulin.

  2007cited by this paper
• Hypoxia-inducible factor 1alpha is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes.

  2007cited by this paper
• The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.

  2007cited by this paper
• The role of HIF-1α in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis

  2006cited by this paper
• Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels.

  2006cited by this paper
• Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha.

  2006cited by this paper
• Hypoxia and HIF-1alpha in osteoarthritis.

  2005cited by this paper
• Hypoxia‐inducible factor as a physiological regulator

  2005cited by this paper
• Binding and regulation of hypoxia-inducible factor-1 by the inhibitory PAS proteins.

  2005cited by this paper
• Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis

  2005cited by this paper
• Correction: Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis

  2005cited by this paper
• Genetic variation in the hypoxia-inducible factor-1alpha gene is associated with type 2 diabetes in Japanese.

  2005cited by this paper
• Hypoxia inducible factor-1 alpha expression in human normal and osteoarthritic chondrocytes.

  2004cited by this paper
• [Hypoxia and angiogenesis in rheumatic diseases].

  2003cited by this paper
• Multiple Splice Variants of the Human HIF-3α Locus Are Targets of the von Hippel-Lindau E3 Ubiquitin Ligase Complex*

  2003cited by this paper
• Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model

  2003cited by this paper
• Hypoxia-inducible factor-1alpha polymorphisms associated with enhanced transactivation capacity, implying clinical significance.

  2003cited by this paper
• Expression and Characterization of Hypoxia-Inducible Factor (HIF)-3α in Human Kidney: Suppression of HIF-Mediated Gene Expression by HIF-3α

  2001cited by this paper
• Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival.

  2001cited by this paper
• Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha.

  2001cited by this paper
• HIF-1: mediator of physiological and pathophysiological responses to hypoxia.

  2000cited by this paper
• Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.

  1998cited by this paper
• Purification and Characterization of Hypoxia-inducible Factor 1 (*)

  1995cited by this paper

• Extracellular vesicles originating from induced pluripotent stem cell-derived chondrocytes facilitate the regeneration of osteoarthritic cartilage

  2026cites this paper
• Synergistic Interplay of dECM and Exosomes in Shaping the Cartilage Matrix Microenvironment: A New Paradigm for Regenerative Medicine

  2026cites this paper
• Role of Pyroptosis in the Pathogenesis of Osteoarthritis: An Updated Review

  2025cites this paper
• Tissue stiffness heterogeneity in the jaw and temporomandibular joint: its impact on tumor metabolism and considerations for in vitro model development

  2025cites this paper
• Modeling the role of ATP metabolism in articular cartilage and osteoarthritis

  2025cites this paper
• Biomaterial Strategies in Osteoarthritis: New Insights Bridging Aging Phenotypes and Hypoxic Microenvironment Pathology

  2025cites this paper
• Unraveling the crucial role of SDF-1 in osteoarthritis progression: IL6/HIF-1α positive feedback and chondrocyte ferroptosis.

  2025cites this paper
• Potential role of gut-related factors in the pathology of cartilage in osteoarthritis

  2025cites this paper
• Inter-Effort Recovery Intermittent Hypoxia and Force Parameters in Sprint Interval Exercise

  2025cites this paper
• Microarray analysis of signalling interactions between inflammation and angiogenesis in subchondral bone in temporomandibular joint osteoarthritis

  2024cites this paper
• Cartilage Homeostasis under Physioxia

  2024cites this paper
• Influence on the temporomandibular joint induced by mandibular malpositioning caused by vertical dimension elevation and occlusal loss in adult rats: An imaging, histological and immunohistochemical study.

  2024cites this paper
• Predicting the potential mechanism of Radix Chimonanthi Pracecocis in treating osteoarthritis by network pharmacology analysis combined with experimental validation.

  2024cites this paper
• A Molecular Perspective on HIF-1α and Angiogenic Stimulator Networks and Their Role in Solid Tumors: An Update

  2024cites this paper
• Hypoxic Conditions Modulate Chondrogenesis through the Circadian Clock: The Role of Hypoxia-Inducible Factor-1α

  2024cites this paper
• Therapeutic Targeting of Hypoxia-Inducible Factors in Cancer

  2024cites this paper
• Potential Therapeutic Mechanism of Radix Angelicae Biseratae and Dipsaci Radix Herb Pair against Osteoarthritis: Based on Network Pharmacology and Molecular Docking

  2023cites this paper
• Osteoarthritis: pathogenic signaling pathways and therapeutic targets

  2023cites this paper
• Simulated Altitude Training and Sport Performance: Protocols and Physiological Effects

  2023cites this paper
• Exploration of Simiao-Yongan Decoction on knee osteoarthritis based on network pharmacology and molecular docking

  2023cites this paper
• In vitro and in vivo investigations on arsenic-induced cartilage degeneration in osteoarthritis.

  2023cites this paper
• Mechanism of HIFs in osteoarthritis

  2023cites this paper
• HIPOKSIJOS VAIDMUO OSTEOARTRITO PATOGENEZEI

  2023cites this paper
• Hexavalent Chromium Induces Cartilage Degeneration and Osteoarthritis Pathogenesis

  2022cites this paper
• The essential anti-angiogenic strategies in cartilage engineering and osteoarthritic cartilage repair

  2022influential citation
• Effects of PHD and HSP90 on erythropoietin production in yak (Bos grunniens) renal interstitial fibroblast-like cells under hypoxia

  2022cites this paper
• Cell Signaling Pathways That Promote Radioresistance of Cancer Cells

  2022cites this paper
• Selective Retinoic Acid Receptor γ Antagonist 7C is a Potent Enhancer of BMP-Induced Ectopic Endochondral Bone Formation

  2022cites this paper
• Interaction of Neurovascular Signals in the Degraded Condylar Cartilage

  2022cites this paper
• HIF-1α in Osteoarthritis: From Pathogenesis to Therapeutic Implications

  2022cites this paper
• The Metabolic Landscape in Osteoarthritis

  2022cites this paper
• A Novel Hypoxia Related Marker in Blood Link to Aid Diagnosis and Therapy in Osteoarthritis

  2022cites this paper
• Effect of the accordion technique on bone regeneration during distraction osteogenesis: A computational study

  2022cites this paper
• Focusing on the hypoxia-inducible factor pathway: role, regulation, and therapy for osteoarthritis

  2022cites this paper
• Research Progress of Traditional Chinese Medicine Intervention on HIF-2α in the Prevention and Treatment of Knee Osteoarthritis

  2022cites this paper
• Possible Implication of Hypoxia-mediated Incomplete Neutrophil Extracellular Trap Formation in Pneumonia-induced Exacerbation of Lung Diseases

  2021cites this paper
• Hypoxia induces DOT1L in articular cartilage to protect against osteoarthritis

  2021cites this paper
• High expression of NDRG3 in osteoarthritis patients

  2021cites this paper
• SETD7 mediates the vascular invasion in articular cartilage and chondrocytes apoptosis in osteoarthriis

  2021cites this paper
• Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications

  2021influential citation
• Hypoxia induces transcription of DOT1L in articular cartilage to protect against osteoarthritis

  2021cites this paper
• Ex vivo osteochondral test system with control over cartilage defect depth – A pilot study to investigate the effect of oxygen tension and chondrocyte based treatments in chondral and full thickness defects in an organ model

  2021cites this paper
• Association of neutrophil extracellular traps with the development of idiopathic osteonecrosis of the femoral head.

  2020cites this paper
• Casticin suppresses monoiodoacetic acid-induced knee osteoarthritis through inhibiting HIF-1α/NLRP3 inflammasome signaling.

  2020cites this paper
• Triiodothyronine potentiates angiogenesis-related factor expression through PI3K/AKT signaling pathway in human osteoarthritic osteoblasts

  2020cites this paper
• The influence of a sustained 10‐day hypoxic bed rest on cartilage biomarkers and subchondral bone in females: The FemHab study

  2020cites this paper
• Desferoxamine protects against glucocorticoid‐induced osteonecrosis of the femoral head via activating HIF‐1α expression

  2020cites this paper
• Hepatocyte growth factor regulates HIF‐1α‐induced nucleus pulposus cell proliferation through MAPK‐, PI3K/Akt‐, and STAT3‐mediated signaling

  2020cites this paper
• Pro chondrogenic effect of mesenchymal stromal cell-based treatment of chondral defects under physioxia in a novel ex vivo organ model

  2020cites this paper
• The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis.

  2020cites this paper
• Network Pharmacology Approach to Uncover the Mechanism Governing the Effect of Simiao Powder on Knee Osteoarthritis

  2020cites this paper
• Targeting H3K9 methyltransferase G9a and its related molecule GLP as a potential therapeutic strategy for cancer

  2020cites this paper
• The Potential Role of Hepatocyte Growth Factor in Degenerative Disorders of the Synovial Joint and Spine

  2020cites this paper
• Highlight Article: Phagocytosis of monosodium urate crystals by human synoviocytes induces inflammation

  2019cites this paper
• The Importance of Physioxia in Mesenchymal Stem Cell Chondrogenesis and the Mechanisms Controlling Its Response

  2019cites this paper
• Increased HIF-1α in Knee Osteoarthritis Aggravate Synovial Fibrosis via Fibroblast-Like Synoviocyte Pyroptosis

  2019cites this paper
• Regulation of energy metabolism in the growth plate and osteoarthritic chondrocytes

  2018cites this paper
• Interleukin-1β exacerbates the catabolic effects of human nucleus pulposus cells through activation of the Nuclear Factor kappa B signaling pathway under hypoxic conditions.

  2018cites this paper
• Pueraria decoction in the treatment of osteoarthritis: network pharmacology analysis and animal model validation

  year unknowncites this paper