Effects of doxycycline on human prostate cancer cells in vitro.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Cancer Letters

• Publication date

  1998-05-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/S0304-3835(98)00003-2PMID 9619856
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of Doxycycline on Cancer Cells in Vitro and in Vivo

  1998cited by this paper
• Inhibition of proliferation and induction of apoptosis by doxycycline in cultured human osteosarcoma cells.

  1997cited by this paper
• High prevalence of bcl-2 oncoprotein expression in small cell lung cancer.

  1995cited by this paper
• Effects of doxycycline on in vitro growth, migration, and gelatinase activity of breast carcinoma cells.

  1995cited by this paper
• Epidermal growth factor-mediated apoptosis of MDA-MB-468 human breast cancer cells.

  1994cited by this paper
• Mediation of c-Myc-induced apoptosis by p53.

  1994cited by this paper
• Activity of type IV collagenases in benign and malignant breast disease.

  1993cited by this paper
• Association of MMP-2 activation potential with metastatic progression in human breast cancer cell lines independent of MMP-2 production.

  1993cited by this paper
• Programmed cell death in an estrogen-independent human breast cancer cell line, MDA-MB-468.

  1992cited by this paper
• Selective endothelial growth inhibition by tetracyclines that inhibit collagenase.

  1992cited by this paper
• Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases.

  1992cited by this paper
• Cleavage of type XI collagen fibers by gelatinase and by extracts of osteoarthritic canine cartilage.

  1991cited by this paper
• Doxycycline inhibits type XI collagenolytic activity of extracts from human osteoarthritic cartilage and of gelatinase.

  1991cited by this paper
• Identification of an inhibitor of neovascularization from cartilage.

  1990cited by this paper
• Metabolism of a cartilage matrix glycoprotein in normal and osteoarthritic canine articular cartilage.

  1986cited by this paper
• Arrest of the proliferation of renal and prostate carcinomas of human origin by inhibition of mitochondrial protein synthesis.

  1986cited by this paper
• Minocycline reduces gingival collagenolytic activity during diabetes. Preliminary observations and a proposed new mechanism of action.

  1983cited by this paper
• Detergent-activation of latent collagenase and resolution of its component molecules.

  1982cited by this paper
• Metastatic potential correlates with enzymatic degradation of basement membrane collagen

  1980cited by this paper

• The Impact of Doxycycline as an Adjunctive Therapy on Prostate-Specific Antigen, Quality of Life, and Cognitive Function in Metastatic Prostate Cancer Patients: A Phase II Randomized Controlled Trial

  2025cites this paper
• FOXP2 suppresses gastric cancer progression by transcriptionally repressing FBXW2 via WASL degradation

  2025cites this paper
• Exopolysaccharides from Bifidobacterium longum supsp. Infantis and Bifidobacterium adolescentis protect gut epithelial cells from antibiotic- induced disruption but do not affect epithelial responses to Escherichia Coli

  2025cites this paper
• Doxycycline-Induced Changes in Circulating MMP or TIMP2 Levels Are Not Associated with Skeletal-Related Event-Free or Overall Survival in Patients with Bone Metastases from Breast Cancer

  2023cites this paper
• Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects

  2023cites this paper
• Repurposed Drugs in Gastric Cancer

  2022cites this paper
• Doxycycline Hydrochloride Regulates Cytoskeletal Rearrangement and Epithelial-To-Mesenchymal Transition in Malignant Rhabdoid Tumour of the Kidney

  2022cites this paper
• Doxycycline Attenuates Cancer Cell Growth by Suppressing NLRP3-Mediated Inflammation

  2021cites this paper
• Anti-cancer potential of some commonly used drugs.

  2021cites this paper
• Doxycycline Changes the Transcriptome Profile of mIMCD3 Renal Epithelial Cells

  2021cites this paper
• Doxycycline at Low Concentrations Could Influence Your Experimental Results When Working With Prostate Cancer Cell Lines

  2020cites this paper
• Therapeutic Efficacy of Antibiotics in the Treatment of Chronic Diseases

  2020cites this paper
• Optimized doxycycline-loaded niosomal formulation for treatment of infection-associated prostate cancer: An in-vitro investigation

  2020cites this paper
• Development of rGO encapsulated polymeric beads as drug delivery system for improved loading and controlled release of doxycycline drug

  2020cites this paper
• Identification of the targeted therapeutic potential of doxycycline for a subset of gastric cancer patients

  2020cites this paper
• HAMPT, A Novel Quadruple Drug Combination Designed for Cancer Metastatic Chemoprevention: From Hypothesis to Proof-of-concept.

  2019cites this paper
• Old wine in new bottles: Drug repurposing in oncology.

  2019cites this paper
• Profilin-1 deficiency leads to SMAD3 upregulation and impaired 3D outgrowth of breast cancer cells

  2018cites this paper
• In vitro anti-cancer activity of Doxycycline on some human cancer cell lines

  2018cites this paper
• Drug repurposing in cancer.

  2017cites this paper
• Doxycycline down-regulates matrix metalloproteinase expression and inhibits NF-κB signaling in LPS-induced PC3 cells.

  2017cites this paper
• Release and cytotoxicity studies of magnetite/Ag/antibiotic nanoparticles: An interdependent relationship.

  2017cites this paper
• Doxycycline protects human intestinal cells from hypoxia/reoxygenation injury: Implications from an in‐vitro hypoxia model

  2017cites this paper
• Doxycycline directly targets PAR1 to suppress tumor progression

  2017cites this paper
• Preclinical trial on the use of doxycycline for the treatment of adenocarcinoma of the duodenum.

  2016cites this paper
• Pharmacodynamic considerations in the use of matrix metalloproteinase inhibitors in cancer treatment

  2016cites this paper
• Sulfur and nitrogen binary doped carbon dots derived from ammonium thiocyanate for selective probing doxycycline in living cells and multicolor cell imaging.

  2016cites this paper
• The genetics of age-related macular degeneration (AMD)--Novel targets for designing treatment options?

  2015cites this paper
• In vitro studies on anti-leukemic effects of tetracycline's analogues and cyclophosphamide

  2015cites this paper
• Low concentrations of doxycycline attenuates FasL-induced apoptosis in HeLa cells

  2015cites this paper
• Doxycycline inhibits leukemic cell migration via inhibition of matrix metalloproteinases and phosphorylation of focal adhesion kinase

  2015cites this paper
• Toxicological Implications and Inflammatory Response in Human Lymphocytes Challenged with Oxytetracycline

  2015cites this paper
• Aspirin, lysine, mifepristone and doxycycline combined can effectively and safely prevent and treat cancer metastasis: prevent seeds from gemmating on soil

  2015cites this paper
• A Role for the Inflammatory Mediators Cox-2 and Metalloproteinases in Cancer Stemness.

  2015cites this paper
• Experimental design for stable genetic manipulation in mammalian cell lines: lentivirus and alternatives

  2015cites this paper
• Mitochondria And Cancer: The Warburg Fact

  2014cites this paper
• Striking growth-inhibitory effects of minocycline on human prostate cancer cell lines.

  2014cites this paper
• Doxycycline Alters Metabolism and Proliferation of Human Cell Lines

  2013cites this paper
• Tetracycline and Glutathione Inhibit Matrix Metalloproteinase Activity: An In Vitro Study Using Cult

  2013cites this paper
• Genotoxic and cytotoxic effects of doxycycline in cultured human peripheral blood lymphocytes

  2012cites this paper
• OTX2 represses myogenic and neuronal differentiation in medulloblastoma cells.

  2012cites this paper
• Tumor and Stem Cell Biology OTX 2 Represses Myogenic and Neuronal Differentiation in Medulloblastoma Cells

  2012cites this paper
• Inhibiting matrix metalloproteinases, an old story with new potentials for cancer treatment.

  2012cites this paper
• Evaluation of bactericidal and fungicidal activity of ferrocenyl or phenyl derivatives in the diphenyl butene series

  2011cites this paper
• Recent developments in patent anti-cancer agents targeting the matrix metalloproteinases (MMPs).

  2010cites this paper
• Doxycycline in mitochondrial mediated pathway of apoptosis: a systematic review.

  2010cites this paper
• Anti-invasion and anti-tumor growth effect of doxycycline treatment for human oral squamous-cell carcinoma--in vitro and in vivo studies.

  2010cites this paper
• Antimetastatic effect of ganoderic acid T in vitro through inhibition of cancer cell invasion

  2010cites this paper
• Doxycycline in Clinical Medicine

  2010cites this paper
• Lowering the apoptotic threshold in colorectal cancer cells by targeting mitochondria

  2010cites this paper
• Doxycycline enhances the Ras‐MAPK signaling and proliferation of mouse thymic epithelial cells

  2009cites this paper
• Doxycycline induces apoptosis in PANC-1 pancreatic cancer cells.

  2009cites this paper
• Doxycycline inhibits the adhesion and migration of melanoma cells by inhibiting the expression and phosphorylation of focal adhesion kinase (FAK).

  2009cites this paper
• Molecular Profiling of Prostate Cancer Patients

  2009cites this paper
• Doxycycline induces caspase‐dependent apoptosis in human pancreatic cancer cells

  2007cites this paper
• Structure-Activity Relationship Investigation of Some New Tetracyclines by Electronic Index Methodology

  2007cites this paper
• Characterization of the RSL1‐dependent conditional expression system in LNCaP prostate cancer cells and development of a single vector format

  2007cites this paper
• Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices.

  2006cites this paper
• Mechanisms of doxycycline-induced cytotoxicity on human bronchial epithelial cells.

  2006cites this paper
• Mitochondria and calpains mediate caspase-dependent apoptosis induced by doxycycline in HeLa cells

  2006cites this paper
• Phase II study of interferon-alpha and doxycycline for advanced renal cell carcinoma

  2006cites this paper
• Acne in adolescence and cause-specific mortality: lower coronary heart disease but higher prostate cancer mortality: the Glasgow Alumni Cohort Study.

  2005cites this paper
• Acne in adolescence and cause-specific mortality: lower coronary heart disease but higher prostate cancer mortality. The Glasgow Alumni Cohort Study

  2005cites this paper
• Doxycycline potentiates antitumor effect of cyclophosphamide in mice.

  2005cites this paper
• Investigation of the effects of HLS5: a novel member of the RBCC family

  2005cites this paper
• Use of Tetracyclines for Bone Metastases

  2005cites this paper
• Inhibition by doxycycline of angiogenesis in the chicken chorioallantoic membrane (CAM)

  2005cites this paper
• Chemically modified tetracyclines as inhibitors of matrix metalloproteinases.

  2004cites this paper
• Influence of chemically modified tetracyclines on proliferation, invasion and migration properties of MDA-MB-468 human breast cancer cells

  2004cites this paper
• Effects of cyclin‐dependent kinase‐5 activity on apoptosis and tau phosphorylation in immortalized mouse brain cortical cells

  2004cites this paper
• Potential Therapeutic Targets for Bone Metastasis

  2004cites this paper
• Stabilization of p53 Is a Novel Mechanism for Proapoptotic Function of NF-κB*

  2004cites this paper
• Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB.

  2004cites this paper
• Doxycycline and other tetracyclines in the treatment of bone metastasis.

  2003cites this paper
• Effect of Combined Cyclooxygenase-2 and Matrix Metalloproteinase Inhibition on Human Sarcoma Xenografts

  2003cites this paper
• Matrix Metalloproteinase Inhibitors in Cancer Therapy

  2003cites this paper
• Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non‐antimicrobial tetracycline analog (COL‐3) in a metastatic prostate cancer model

  2002cites this paper
• Recent advances in inducible expression in transgenic mice.

  2002cites this paper
• Development of matrix metalloproteinase inhibitors in cancer therapy.

  2002cites this paper
• Doxycycline induces apoptosis by way of caspase-3 activation with inhibition of matrix metalloproteinase in human T-lymphoblastic leukemia CCRF-CEM cells.

  2002cites this paper
• Effects of chemically modified tetracyclines (CMTs) in sensitive, multidrug resistant and apoptosis resistant leukaemia cell lines

  2002cites this paper
• Effects of chemically modified tetracyclines (CMTs) in sensitive, multidrug resistant and apoptosis resistant leukaemia cell lines

  2001cites this paper
• Development of matrix metalloproteinase inhibitors in cancer therapy.

  2001cites this paper
• Biological, non-antibiotic properties of semi-synthetic and chemically modified tetracyclines — a structured, annotated bibliography

  2001cites this paper
• Inhibition of mesothelioma cell growth in vitro by doxycycline.

  2001cites this paper
• Tetracyclines induce apoptosis in osteoclasts.

  2000cites this paper
• Effects of tetracyclines on angiogenesis in vitro.

  2000cites this paper
• Doxycycline induces Fas/Fas ligand-mediated apoptosis in Jurkat T lymphocytes.

  1999cites this paper
• Conditional transformation of rat embryo fibroblast cells by a cyclin D1-cdk4 fusion gene

  1999cites this paper
• Role of thymic peptides as transmitters between the neuroendocrine and immune systems.

  1999cites this paper
• MMP Inhibition in Prostate Cancer

  1999cites this paper
• Matrix Metalloproteinase Inhibition: From The Jurassic To The Third Millennium

  1999cites this paper
• Matrix metalloproteinases and their inhibitors in tumour growth and invasion.

  1999cites this paper
• Effects of Doxycycline on Cancer Cells in Vitro and in Vivo

  1998influential citation