Parkinsonism in cirrhosis: pathogenesis and current therapeutic options

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Metabolic brain disease

• Publication date

  2013-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s11011-012-9341-7PMID 23086199
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Liver: Risk of falls in cirrhosis predicted by psychometric testing

  2012cited by this paper
• Chronic acquired hepatocerebral degeneration: effects of liver transplantation on neurological manifestations

  2011cited by this paper
• Acquired hepatocerebral degeneration.

  2011cited by this paper
• Parkinsonism in patients with cirrhosis: coincidence or consequence?

  2011cited by this paper
• Acquired hepatocerebral degeneration: clinical characteristics and MRI findings

  2010cited by this paper
• Are Acquired Hepatocerebral Degeneration and Hepatic Myelopathy Reversible?

  2009cited by this paper
• Acquired hepatocerebral degeneration

  2009cited by this paper
• Effect of trientine on manganese intoxication in a patient with acquired hepatocerebral degeneration

  2008cited by this paper
• Neuronal cell death in hepatic encephalopathy

  2007cited by this paper
• Manganese-induced Parkinsonism associated with methcathinone (Ephedrone) abuse.

  2007cited by this paper
• Acquired hepatocerebral degeneration in a patient with HCV cirrhosis: Complete resolution with subsequent recurrence after liver transplantation

  2006cited by this paper
• Neurologic spectrum of chronic liver failure and basal ganglia T1 hyperintensity on magnetic resonance imaging: probable manganese neurotoxicity.

  2005cited by this paper
• Chronic parkinsonism associated with cirrhosis: a distinct subset of acquired hepatocerebral degeneration.

  2003influential reference
• Persistence of mild parkinsonism 4 months after liver transplantation in patients with preoperative minimal hepatic encephalopathy: a study on neuroradiological and blood manganese changes

  2002cited by this paper
• Movement Dysfunction and Hepatic Encephalopathy

  2001cited by this paper
• Magnetic resonance imaging and proton spectroscopic alterations correlate with parkinsonian signs in patients with cirrhosis.

  2000cited by this paper
• Altered striatal dopamine D2 receptor density and dopamine transport in a patient with hepatic encephalopathy

  2000influential reference
• Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction.

  1999cited by this paper
• Diencephalic and cerebellar pathology in alcoholic and nonalcoholic patients with end‐stage liver disease

  1997cited by this paper
• Distinctive pattern of Bergmann glial pathology in human hepatic encephalopathy.

  1997cited by this paper
• Increased Density of Catalytic Sites and Expression of Brain Monoamine Oxidase A in Humans with Hepatic Encephalopathy

  1997cited by this paper
• Presynaptic and postsynaptic striatal dopaminergic function in patients with manganese intoxication

  1997cited by this paper
• Increased blood manganese in cirrhotic patients: Relationship to pallidal magnetic resonance signal hyperintensity and neurological symptoms

  1996cited by this paper
• Accumulation of manganese and copper in pallidum of cirrhotic patients: role in the pathogenesis of hepatic encephalopathy?

  1995cited by this paper
• Manganese toxicity, dopaminergic dysfunction and hepatic encephalopathy

  1995cited by this paper
• Increased activities of MAOA and MAOB in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy.

  1993cited by this paper
• Selective loss of pallidal dopamine D2 receptor density in hepatic encephalopathy.

  1993cited by this paper
• Hyperintense basal ganglia on T1-weighted MR images in patients receiving parenteral nutrition.

  1991cited by this paper
• Portal-systemic encephalopathy: presence of basal ganglia lesions with high signal intensity on MR images.

  1991cited by this paper
• Improvement in chronic hepatocerebral degeneration following liver transplantation.

  1990cited by this paper
• Monoamines and metabolites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy

  1989cited by this paper
• Chronic manganese intoxication.

  1989cited by this paper
• Bromocriptine in the Treatment of Chronic Hepatic Encephalopathy

  1984cited by this paper
• Distribution of cerebral lesions in acquired hepatocerebral degeneration.

  1981cited by this paper
• Treatment of cirrhotic hepatic encephalopathy with L-dopa. A controlled trial.

  1980cited by this paper
• Successful use of bromocriptine in the treatment of chronic hepatic encephalopathy.

  1980cited by this paper
• Treatment of chronic portal systemic encephalopathy with bromocriptine: a double-blind controlled trial.

  1979cited by this paper
• Treatment of chronic hepatic encephalopathy with levodopa 1

  1974cited by this paper
• Chronic manganese intoxication.

  1974cited by this paper
• Treatment of chronic hepatic encephalopathy with levodopa 1

  1974cited by this paper
• A controlled trial

  1971cited by this paper
• Hepatic cirrhosis with post-shunt myelopathy.

  1970cited by this paper

• Rifaximin's therapeutic spectrum: approved indications and experimental insights into emerging uses.

  2026cites this paper
• The role of presynaptic dopaminergic imaging in acquired neurological conditions affecting basal ganglia: a systematic review

  2025cites this paper
• Hepatic Dysfunction and Neuropsychiatric Sequelae Through Manganese Toxicity

  2025cites this paper
• An iPSC-derived neuronal model reveals manganese’s role in neuronal endocytosis, calcium flux and mitochondrial bioenergetics

  2025cites this paper
• Reactive astrocytes targeting with oral vitamin A: Efficient neuronal regeneration for Parkinson's disease treatment and reversal of associated liver fibrosis

  2023cites this paper
• Manganeso asociado con degeneración hepatolenticular no wilsoniana como causa infrecuente de encefalopatía: reporte de caso

  2023cites this paper
• The Combined Inactivation of Intestinal and Hepatic ZIP14 Exacerbates Manganese Overload in Mice

  2022cites this paper
• Manganese efflux transporter SLC30A10 missense polymorphism T95I associated with liver injury retains manganese efflux activity.

  2022cites this paper
• Acquired Hepatocerebral Degeneration After a Splenorenal Shunt in the Sub-Saharan Africa Context: A Case Report and Brief Review of Literature

  2022cites this paper
• Acquired hepatocerebral degeneration in a metastatic neuroendocrine tumor long-term survivor — an update on neuroendocrine neoplasm’s treatment: A case report

  2021cites this paper
• Up-regulation of the manganese transporter SLC30A10 by hypoxia-inducible factors defines a homeostatic response to manganese toxicity

  2021cites this paper
• Neurologic Manifestations of Systemic Disease: Movement Disorders

  2021cites this paper
• Immune checkpoint inhibitor triggered parkinsonism in a patient with metastatic melanoma

  2020cites this paper
• Alpha-Synuclein in Alcohol Use Disorder, Connections with Parkinson’s Disease and Potential Therapeutic Role of 5’ Untranslated Region-Directed Small Molecules

  2020cites this paper
• Manganese, a Likely Cause of 'Parkinson's in Cirrhosis', a Unique Clinical Entity of Acquired Hepatocerebral Degeneration

  2020cites this paper
• Spontaneous portosystemic shunts in liver cirrhosis: new approaches to an old problem

  2020cites this paper
• Maintaining Translational Relevance in Animal Models of Manganese Neurotoxicity.

  2020cites this paper
• New-onset extrapyramidal symptoms in hepatic cirrhosis without neuroimaging signs of encephalopathy.

  2019cites this paper
• Liver Transplantation in Wilson Disease

  2019cites this paper
• Hepatitis B and C virus infection as a risk factor for Parkinson's disease in Israel-A nationwide cohort study.

  2019cites this paper
• Pathophysiology of hepatic encephalopathy and future treatment options

  2019cites this paper
• Pathophysiology of hepatic encephalopathy and future treatment options.

  2019cites this paper
• A discussion of new-onset extrapyramidal syndrome without tremor and neuroimaging signs of encephalopathy following hepatic cirrhosis

  2019cites this paper
• How to approach a patient with parkinsonism - red flags for atypical parkinsonism.

  2019cites this paper
• Sleep in ambulatory patients with stable cirrhosis of the liver.

  2018cites this paper
• Implications of Manganese in Chronic acquired hepatocerebral degeneration.

  2018cites this paper
• SLC30A10 transporter in the digestive system regulates brain manganese under basal conditions while brain SLC30A10 protects against neurotoxicity

  2018cites this paper
• Neurological disorders in liver transplant candidates: Pathophysiology and clinical assessment.

  2017cites this paper
• Deficiency in the manganese efflux transporter SLC30A10 induces severe hypothyroidism in mice

  2017cites this paper
• Toxic-Induced Parkinsonism

  2017cites this paper
• Zebrafish disease models to study the pathogenesis of inherited manganese transporter defects and provide a route for drug discovery

  2017cites this paper
• Anti-ammonia treatment-responsive myoclonus as initial presentation of acquired hepatocerebral degeneration.

  2017cites this paper
• Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production

  2017cites this paper
• 18F-FP-CIT dopamine transporter PET findings in cirrhotic patients with parkinsonism.

  2017cites this paper
• Familial manganese-induced neurotoxicity due to mutations in SLC30A10 or SLC39A14.

  2017cites this paper
• N‐oleoyldopamine modulates activity of midbrain dopaminergic neurons through multiple mechanisms

  2017cites this paper
• Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis

  2017cites this paper
• Inherited Disorders of Manganese Metabolism.

  2017cites this paper
• Recent Updates on Acquired Hepatocerebral Degeneration

  2017cites this paper
• Liver Disease and Neurology

  2017cites this paper
• Structural Elements in the Transmembrane and Cytoplasmic Domains of the Metal Transporter SLC30A10 Are Required for Its Manganese Efflux Activity*

  2016cites this paper
• Neurologic Manifestations of Systemic Disease ( N Scolding and C Rice , Section Editors ) Management of Neurologic Manifestations in Patients with Liver Disease

  2016cites this paper
• Exposure, epidemiology, and mechanism of the environmental toxicant manganese

  2016cites this paper
• Complete title : Parkinsonian Syndrome and Ataxia as a Presenting Finding of Acquired Hepatocerebral Degeneration

  2016cites this paper
• SLC30A10: A novel manganese transporter

  2015cites this paper
• Manganese homeostasis in the nervous system

  2015cites this paper
• Pathogenesis of hepatic encephalopathy in cirrhosis: the concept of synergism revisited

  2015influential citation
• Encephalopathy in Wilson disease: copper toxicity or liver failure?

  2015cites this paper
• Etiology of cirrhosis predicts deterioration of “brain reserve” after hepatic encephalopathy or transjugular intrahepatic portosystemic shunt

  2015cites this paper
• Movement Disorders in Non-Wilsonian Cirrhotic Patients: A Report of the Prevalence and Risk Factors from a Study Done in a Medical School in an Agricultural-Based Community

  2015cites this paper
• Reprint of: Nutrition in the Management of Cirrhosis and its Neurological Complications.

  2015cites this paper
• Nutrition in Chronic Liver Disease

  2015cites this paper
• Hepatobiliary Quiz (Answers)-14 (2015).

  2015cites this paper
• Neurologic Manifestations of Chronic Liver Disease and Liver Cirrhosis.

  2015cites this paper
• Hepatobiliary quiz 11 (2014).

  2014cites this paper
• Parkinsonian syndrome and ataxia as a presenting finding of acquired hepatocerebral degeneration

  2014cites this paper
• Zwyrodnienie wątrobowo-soczewkowe nabyte — obraz kliniczny, diagnostyka i leczenie

  2014influential citation
• Hepatic encephalopathy in alcoholic cirrhosis.

  2014cites this paper
• Puzzles in Practice

  2014cites this paper
• Structural and microstructral imaging of the brain in alcohol use disorders.

  2014influential citation
• SLC30A10 Is a Cell Surface-Localized Manganese Efflux Transporter, and Parkinsonism-Causing Mutations Block Its Intracellular Trafficking and Efflux Activity

  2014cites this paper
• From the liver to the brain: manganese matters

  2014cites this paper
• Hepatic Encephalopathy: A Primary Neurogliopathy

  2014cites this paper
• Nutrition in the management of cirrhosis and its neurological complications.

  2014cites this paper
• Manganese and the brain.

  2013influential citation
• The liver–brain axis in liver failure: neuroinflammation and encephalopathy

  2013cites this paper
• Manganese Associated with Non-Wilsonian Hepatolenticular Degeneration as a Rare Cause of Encephalopathy: Case Report

  year unknowncites this paper