Deoxyelephantopin from Elephantopus scaber L. induces cell-cycle arrest and apoptosis in the human nasopharyngeal cancer CNE cells.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2011-07-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bbrc.2011.06.144PMID 21741953
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tumor Immunology

  2018cited by this paper
• 6-O-Angeloylenolin induced cell-cycle arrest and apoptosis in human nasopharyngeal cancer cells.

  2011cited by this paper
• Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cells.

  2010cited by this paper
• Deoxyelephantopin, a novel multifunctional agent, suppresses mammary tumour growth and lung metastasis and doubles survival time in mice

  2010cited by this paper
• Antiproliferative Activities of Five Chinese Medicinal Herbs and Active Compounds in Elephantopus scaber

  2009cited by this paper
• 2β-(Isobutyryloxy)florilenalin, a Sesquiterpene Lactone Isolated from the Medicinal Plant Centipeda minima, Induces Apoptosis in Human Nasopharyngeal Carcinoma CNE Cells

  2009cited by this paper
• Deregulation of the Akt pathway in human cancer.

  2008cited by this paper
• Journal of Translational Medicine Lentivirus-mediated Rnai Silencing Targeting Abcc2 Increasing the Sensitivity of a Human Nasopharyngeal Carcinoma Cell Line against Cisplatin

  2008cited by this paper
• Nasopharyngeal carcinoma—Review of the molecular mechanisms of tumorigenesis

  2008cited by this paper
• Deoxyelephantopin inhibits cancer cell proliferation and functions as a selective partial agonist against PPARgamma.

  2008cited by this paper
• Latent membrane protein 1 of Epstein-Barr virus regulates p53 phosphorylation through MAP kinases.

  2007cited by this paper
• Antitumor activities of the four sesquiterpene lactones from Elephantopus scaber L.

  2006cited by this paper
• The global health burden of infection‐associated cancers in the year 2002

  2006cited by this paper
• [Significance of EGFR and p-ERK expression in nasopharyngeal carcinoma].

  2006cited by this paper
• Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-kappaB (nf-kappaB) activation and nf-kappaB-regulated gene expression.

  2006cited by this paper
• Isodeoxyelephantopin, a Novel Sesquiterpene Lactone, Potentiates Apoptosis, Inhibits Invasion, and Abolishes Osteoclastogenesis through Suppression of Nuclear Factor-κB (NF-κB) Activation and NF-κB-Regulated Gene Expression

  2006cited by this paper
• Mammalian cyclin-dependent kinases.

  2005cited by this paper
• Protein Kinases and Phosphatases: The Yin and Yang of Protein Phosphorylation and Signaling Review

  2004cited by this paper
• Molecular mechanisms of caspase regulation during apoptosis

  2004cited by this paper
• Regulation of apoptosis by Bcl‐2 family proteins

  2003cited by this paper
• The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions.

  2003cited by this paper
• Cell death regulation by the Bcl‐2 protein family in the mitochondria

  2003cited by this paper
• Death and anti-death: tumour resistance to apoptosis

  2002cited by this paper
• Organelle-specific initiation of cell death pathways

  2001cited by this paper
• Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.

  2001cited by this paper
• Long-term survival of nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy.

  2000cited by this paper
• Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099.

  1998cited by this paper
• Caspases: the executioners of apoptosis.

  1997cited by this paper
• Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c.

  1996cited by this paper
• Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling.

  1995cited by this paper
• The mitochondrial permeability transition.

  1995cited by this paper
• Detection of subclinical riasopharyngeal carcinoma by fibreoptic endoscopy and multiple biopsy

  1990cited by this paper
• Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

  1983cited by this paper
• ANTITUMOR AGENTS. XV. DEOXYELEPHANTOPIN, AN ANTITUMOR PRINCIPLE FROM ELEPHANTOPUS CAROLINIANUS

  1976cited by this paper
• Antitumor agents. XV: Deoxyelephantopin, an antitumor principle from Elephantopus carolinianus Willd.

  1975cited by this paper

• Inhibition of the PI3K/AKT signaling pathway contributes to the anti-renal cell carcinoma effects of deoxyelephantopin.

  2025cites this paper
• Phytosesquiterpene lactones deregulate mitochondrial activity and phenotypes associated with triple-negative breast cancer metastasis.

  2024cites this paper
• Deoxyelephantopin induces apoptosis and cell cycle arrest in GL261 glioblastoma cells

  2024cites this paper
• Exploiting new strategies in combating head and neck carcinoma: A comprehensive review on phytochemical approaches passing through PI3K/Akt/mTOR signaling pathway

  2024cites this paper
• Sesquiterpene lactones as emerging biomolecules to cease cancer by targeting apoptosis

  2024cites this paper
• The specialized sesquiterpenoids produced by the genus Elephantopus L.: Chemistry, biological activities and structure-activity relationship exploration.

  2024cites this paper
• Assessing the therapeutic potential of Elephantopus scaber extract in hepatocellular carcinoma by inhibiting the PI3K/Akt pathway

  2024cites this paper
• Sesquiterpenoids from the whole plants of Elephantopus mollis with cytotoxicity activities

  2023cites this paper
• Scabertopin Derived from Elephantopus scaber L. Mediates Necroptosis by Inducing Reactive Oxygen Species Production in Bladder Cancer In Vitro

  2022cites this paper
• Deoxyelephantopin and Its Isomer Isodeoxyelephantopin: Anti-Cancer Natural Products with Multiple Modes of Action

  2022cites this paper
• Deoxyelephantopin Induces Apoptosis and Enhances Chemosensitivity of Colon Cancer via miR-205/Bcl2 Axis

  2022cites this paper
• Targeting thioredoxin reductase by deoxyelephantopin from Elephantopus scaber triggers cancer cell apoptosis.

  2021cites this paper
• The effect of Deoxyelephantopin enhances Doxorubicin Sensitivity to MCF-7 Cancer Cells

  2021cites this paper
• Cinnamomi Ramulus inhibits the growth of colon cancer cells via Akt/ERK signaling pathways

  2021cites this paper
• Synergistic Cytotoxicity between Elephantopus scaber and Tamoxifen on MCF-7-Derived Multicellular Tumor Spheroid

  2021cites this paper
• Prevention and Treatment of Cancer with Alternative Anticancer Approach: Current Scenario

  2020cites this paper
• Deoxyelephantopin induces ROS-mediated autophagy and apoptosis in human colorectal cancer in vitro and in vivo

  2020cites this paper
• Elephantopus mollis Kunth extracts induce antiproliferation and apoptosis in human lung cancer and myeloid leukemia cells.

  2020cites this paper
• Deoxyelephantopin, a novel naturally occurring phytochemical impairs growth, induces G2/M arrest, ROS-mediated apoptosis and modulates lncRNA expression against uterine leiomyoma.

  2020cites this paper
• In vitro and in vivo antitumor activity of deoxyelephantopin from a potential medicinal plant Elephantopus scaber against Ehrlich ascites carcinoma

  2019cites this paper
• Natural Products and Synthetic Analogs as a Source of Antitumor Drugs

  2019cites this paper
• Medicinal Plants Against Cancer

  2018cites this paper
• Microwave assisted green synthesis of silver nanoparticles using leaf extract of elephantopus scaber and its environmental and biological applications

  2018influential citation
• Synthesis and evaluation of new sterol derivatives as potential antitumor agents

  2018cites this paper
• LC-MS/MS determination of deoxyelephantopin, a novel anti-tumor candidate in rat plasma and its application to a pharmacokinetic study in rats

  2018cites this paper
• Molecular mechanisms of anticancer activity of deoxyelephantopin in cancer cells

  2017cites this paper
• Ethyl Caffeate Ameliorates Collagen-Induced Arthritis by Suppressing Th1 Immune Response

  2017cites this paper
• The effects of deoxyelephantopin on the cardiac delayed rectifier potassium channel current (IKr) and human ether-a-go-go-related gene (hERG) expression.

  2017cites this paper
• Deoxyelephantopin induces apoptosis in HepG2 cells via oxidative stress, NF‐&kgr;B inhibition and mitochondrial dysfunction

  2017cites this paper
• Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.

  2017cites this paper
• Deoxyelephantopin and Isodeoxyelephantopin as Potential Anticancer Agents with Effects on Multiple Signaling Pathways

  2017influential citation
• Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop

  2017cites this paper
• Retraction Retracted : The Effect of Elephantopus scaber L . on Liver Regeneration after Partial Hepatectomy Evidence-Based Complementary and Alternative Medicine

  2017cites this paper
• Development of Anticancer Agents from Plant-Derived Sesquiterpene Lactones.

  2016cites this paper
• Chemical Constituents of Elephantopus scaber

  2016cites this paper
• Deoxyelephantopin from Elephantopus scaber Inhibits HCT116 Human Colorectal Carcinoma Cell Growth through Apoptosis and Cell Cycle Arrest

  2016cites this paper
• Novel sesquiterpene lactone analogues as potent anti‐breast cancer agents

  2016cites this paper
• A Novel Plant Sesquiterpene Lactone Derivative, DETD-35, Suppresses BRAFV600E Mutant Melanoma Growth and Overcomes Acquired Vemurafenib Resistance in Mice

  2016cites this paper
• Elephantopus scaber induces apoptosis through ROS-dependent mitochondrial signaling pathway in HCT116 human colorectal carcinoma cells.

  2015cites this paper
• Proteomic Analysis of Anticancer TCMs Targeted at Mitochondria

  2015cites this paper
• Anti-metastatic effect of deoxyelephantopin from Elephantopus scaber in A549 lung cancer cells in vitro

  2015cites this paper
• A REVIEW OF ANTICANCER POTENTIAL OF ELEPHANTOPUS SCABER AND ITS PHYTOCONSTITUENTS

  2015cites this paper
• Traditional Ayurvedic medicines : pathway to develop anti-cancer drugs

  2015cites this paper
• Hepatoprotective Effects of Traditional Chinese Medicine on Liver Fibrosis from Ethanol Administration following Partial Hepatectomy.

  2015cites this paper
• Centipeda minima (Ebushicao) extract inhibits PI3K-Akt-mTOR signaling in nasopharyngeal carcinoma CNE-1 cells

  2015cites this paper
• Elephantopus scaber Linn.: A review on its ethnomedical, phytochemical and pharmacological profile

  2014cites this paper
• A review on pharmacology and toxicology of Elephantopus scaber Linn.

  2014cites this paper
• Deoxyelephantopin impairs growth of cervical carcinoma SiHa cells and induces apoptosis by targeting multiple molecular signaling pathways

  2014cites this paper
• Isodeoxyelephantopin from Elephantopus scaber (Didancao) induces cell cycle arrest and caspase-3-mediated apoptosis in breast carcinoma T47D cells and lung carcinoma A549 cells

  2014cites this paper
• Antineoplastic effects of deoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber, on lung adenocarcinoma (A549) cells.

  2013cites this paper
• Evaluation of in vitro cytochrome P450 induction and inhibition activity of deoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber L.

  2013cites this paper
• Quantitative proteomics characterization on the antitumor effects of isodeoxyelephantopin against nasopharyngeal carcinoma

  2013cites this paper
• The Effect of Elephantopus scaber L. on Liver Regeneration after Partial Hepatectomy

  2013cites this paper
• Elephantopus Species: Traditional Uses, Pharmacological Actions and Chemical Composition.

  2013cites this paper
• Developing Phytocompounds from Medicinal Plants as Immunomodulators

  2012influential citation
• Pleiotrophic effects of natural products in ROS-induced carcinogenesis: the role of plant-derived natural products in oral cancer chemoprevention.

  2012cites this paper
• Anti-proliferative Activity and Apoptotic Potential of Britannin, a Sesquiterpene Lactone from Inula aucheriana

  2012cites this paper