PAT within the QbD Framework: Real-Time End Point Detection for Powder Blends in a Compliant Environment

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Pharmaceutical Innovation

• Publication date

  2012-02-03

• Fields of study

  Medicine, Chemistry, Engineering

• Identifiers
  DOI 10.1007/s12247-012-9119-9
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• A new PAT/QbD approach for the determination of blend homogeneity: combination of on-line NIRS analysis with PC Scores Distance Analysis (PC-SDA).

  2011cited by this paper
• Real-time on-line blend uniformity monitoring using near-infrared reflectance spectrometry: a noninvasive off-line calibration approach.

  2009cited by this paper
• Real-time monitoring of powder mixing in a convective blender using non-invasive reflectance NIR spectrometry.

  2008cited by this paper
• Simple assessment of homogeneity in pharmaceutical mixing processes using a near-infrared reflectance probe and control charts.

  2006cited by this paper
• Caterpillar: an adaptive algorithm for detecting process changes from acoustic emission signals

  2005cited by this paper
• Quantitative in-line monitoring of powder blending by near infrared reflection spectroscopy

  2002cited by this paper
• Monitoring powder blending in pharmaceutical processes by use of near infrared spectroscopy.

  2002cited by this paper
• On-Line Monitoring of Powder Blending with Near-Infrared Spectroscopy

  1998cited by this paper
• Near-infrared spectroscopic characterization of pharmaceutical powder blends.

  1996cited by this paper
• On-line monitoring of powder blend homogeneity by near-infrared spectroscopy.

  1996cited by this paper
• Monitoring powder blending by NIR spectroscopy

  1995cited by this paper

• A Review of Formulation and Process Considerations for Achieving Stability in Solid Dispersions Produced via the Spray Drying Technique

  2025cites this paper
• The role of process systems engineering in applying quality by design (QbD) in mesenchymal stem cell production

  2023cites this paper
• Near infrared spectroscopy for blend uniformity monitoring: An innovative qualitative application based on the coefficient of determination

  2022cites this paper
• Quality by Design (QbD) application for the pharmaceutical development process

  2022cites this paper
• A review of in-line and on-line measurement techniques to monitor industrial mixing processes

  2020cites this paper
• Product Development, Manufacturing, and Packaging of Solid Dosage Forms Under QbD and PAT Paradigm: DOE Case Studies for Industrial Applications

  2019cites this paper
• Raw Material Variability and Its Impact on the Online Adaptive Control of Cohesive Powder Blend Homogeneity Using NIR Spectroscopy

  2019cites this paper
• Control system implementation and plant-wide control of continuous pharmaceutical manufacturing pilot plant (end-to-end manufacturing process)

  2018cites this paper
• Real time release testing of tablet content and content uniformity.

  2018cites this paper
• In-line ATR-UV and Raman Spectroscopy for Monitoring API Dissolution Process During Liquid-Filled Soft-Gelatin Capsule Manufacturing

  2016cites this paper
• In-Process Control Assay of Pharmaceutical Microtablets Using Hyperspectral Imaging Coupled with Multivariate Analysis.

  2016cites this paper
• Blend uniformity evaluation during continuous mixing in a twin screw granulator by in-line NIR using a moving F-test.

  2016cites this paper
• An efficient, maintenance free and approved method for spectroscopic control and monitoring of blend uniformity: The moving F-test.

  2015cites this paper
• Scientific and Regulatory Considerations for Implementing Mathematical Models in the Quality by Design (QbD) Framework

  2014cites this paper
• Process analytical technology (PAT) tools for the cultivation step in biopharmaceutical production

  2013cites this paper
• Use of near-infrared spectroscopy to quantify drug content on a continuous blending process: influence of mass flow and rotation speed variations.

  2013cites this paper
• Batch and continuous blending of particulate material studied by near-infrared spectroscopy

  2013cites this paper