Branched-chain amino acid depletion conditions bone marrow for hematopoietic stem cell transplantation avoiding amino acid imbalance-associated toxicity

Highlights • Branched-chain amino acid (BCAA) imbalance (low valine and high isoleucine/leucine) inhibits hematopoietic stem cell (HSC) proliferation and survival.• Low BCAA culture does not block HSC growth but poorly supports HSC maintenance.• Dietary BCAA depletion conditions the mouse bone marrow (BM) for HSC transplantation.• BCAA conditioning improves survival and red blood cell (RBC) counts compared with valine conditioning.

• Publication year

  2018

• Venue

  Experimental Hematology

• Publication date

  2018-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.exphem.2018.04.004PMID 29705267PMCID 6052250
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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