Chance and necessity in chromosomal gene distributions.

By analyzing the spacing of genes on chromosomes, we find that transcriptional and RNA-processing regulatory sequences outside coding regions leave footprints on the distribution of intergenic distances. Using analogies between genes on chromosomes and one-dimensional gases, we constructed a statistical null model. We used this to estimate typical upstream and downstream regulatory sequence sizes in various species. Deviations from this model reveal bi-directional transcriptional regulatory regions in Saccharomyces cerevisiae and bi-directional terminators in Escherichia coli.

• Publication year

  2008

• Venue

  Trends in Genetics

• Publication date

  2008-03-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.tig.2008.02.004arXiv 0803.1261PMID 18378035
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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