The plastic d-serine signaling pathway: Sliding from neurons to glia and vice-versa.

d-Serine is now recognized as the main co-agonist for NMDA receptors. For years it was thought to be exclusively produced by astrocytes and was thus viewed as the archetype of gliotransmitters. Recent research have challenged this long cherished and appealing view by showing that in physiological conditions d-erine would rather originate from neurons but not from glia. In the present review and in the light of the emerging serine shuttle model, we ambition to offer a new reading direction of the glia-neuron cross-talk in shaping the metabolism and the functions of d-serine in cerebral communication in normal and pathological conditions by re-interpretating some seminal findings.

• Publication year

  2019

• Venue

  Neuroscience Letters

• Publication date

  2019-01-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.neulet.2018.05.039PMID 29852209
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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