Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+/Ca2+ exchanger.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Neurobiology of Disease

• Publication date

  2012-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.nbd.2011.12.051PMID 22249110PMCID PMC3299854
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• KB‐R7943, an inhibitor of the reverse Na+/Ca2+ exchanger, blocks N‐methyl‐D‐aspartate receptor and inhibits mitochondrial complex I

  2011cited by this paper
• Failures and successes of NMDA receptor antagonists: Molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults

  2011influential reference
• Altered calcium currents and axonal growth in Nf1 haploinsufficient mice

  2010cited by this paper
• Calpain activation and Na+/Ca2+ exchanger degradation occur downstream of calcium deregulation in hippocampal neurons exposed to excitotoxic glutamate

  2009cited by this paper
• Role of cyclophilin D-dependent mitochondrial permeability transition in glutamate-induced calcium deregulation and excitotoxic neuronal death.

  2009cited by this paper
• Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity

  2009cited by this paper
• Stimulation of glutamate receptors in cultured hippocampal neurons causes Ca2+-dependent mitochondrial contraction.

  2009cited by this paper
• Excitotoxic and excitoprotective mechanisms

  2007influential reference
• ANNINE-6plus, a voltage-sensitive dye with good solubility, strong membrane binding and high sensitivity

  2007cited by this paper
• Reversed Na+/Ca2+ Exchange Contributes to Ca2+ Influx and Respiratory Burst in Microglia

  2007cited by this paper
• Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity

  2006cited by this paper
• A Selective Inhibitor of Na+/Ca2+ Exchanger, SEA0400, Preserves Cardiac Function and High-Energy Phosphates against Ischemia/Reperfusion Injury

  2006cited by this paper
• Pharmacological intervention at ionotropic glutamate receptor complexes.

  2006cited by this paper
• Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons.

  2006cited by this paper
• Topics on the Na+/Ca2+ exchanger: pharmacological characterization of Na+/Ca2+ exchanger inhibitors.

  2006cited by this paper
• Na(+)/Ca(2+) exchanger expression and function in a rabbit model of myocardial infarction.

  2006cited by this paper
• Na+/Ca2+ Exchanger Expression and Function in a Rabbit Model of Myocardial Infarction

  2006cited by this paper
• The role of excitotoxicity in neurodegeneration.

  2006cited by this paper
• Decreased Neuronal Death in Na+/H+ Exchanger Isoform 1-Null Mice after In Vitro and In Vivo Ischemia

  2005cited by this paper
• Exporting calcium from cells.

  2005cited by this paper
• Ca2+ signals and death programmes in neurons

  2005cited by this paper
• Pharmacology of Brain Na+/Ca2+ Exchanger: From Molecular Biology to Therapeutic Perspectives

  2004cited by this paper
• Role of Na+-Ca2+ exchanger in myocardial ischemia/reperfusion injury: evaluation using a heterozygous Na+-Ca2+ exchanger knockout mouse model.

  2004cited by this paper
• Dearth of glutamate transporters contributes to striatal excitotoxicity.

  2004cited by this paper
• Glutamate-pyruvate transaminase protects against glutamate toxicity in hippocampal slices.

  2003cited by this paper
• The Relationship between Free and Total Calcium Concentrations in the Matrix of Liver and Brain Mitochondria*

  2003cited by this paper
• Instrumental role of Na+ in NMDA excitotoxicity in glucose‐deprived and depolarized cerebellar granule cells

  2002cited by this paper
• Generation, Control, and Processing of Cellular Calcium Signals

  2001cited by this paper
• Important role of reverse Na(+)-Ca(2+) exchange in spinal cord white matter injury at physiological temperature.

  2000cited by this paper
• Inhibitory effect of amiodarone on Na+/Ca2+ exchange current in guinea‐pig cardiac myocytes

  2000cited by this paper
• Enzymatic Degradation Protects Neurons from Glutamate Excitotoxicity

  2000cited by this paper
• Sodium/calcium exchange: its physiological implications.

  1999cited by this paper
• N-methyl-D-aspartate excitotoxicity: relationships among plasma membrane potential, Na(+)/Ca(2+) exchange, mitochondrial Ca(2+) overload, and cytoplasmic concentrations of Ca(2+), H(+), and K(+).

  1999cited by this paper
• Mitochondrial transport of cations: channels, exchangers, and permeability transition.

  1999cited by this paper
• Mitochondrial dysfunction in Parkinson's disease.

  1999cited by this paper
• Comparison of Na+-Ca2+ exchange current elicited from isolated rabbit ventricular myocytes by voltage ramp and step protocols

  1999cited by this paper
• Bioenergetics in Huntington's Disease

  1999influential reference
• Blockade of NMDA channels in acutely isolated rat hippocampal neurons by the Na+/Ca2+ exchange inhibitor KB-R7943.

  1999cited by this paper
• Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons.

  1998cited by this paper
• Na+-dependent Release of Mg2+ from an Intracellular Pool in Rat Sublingual Mucous Acini*

  1996cited by this paper
• A Novel Isothiourea Derivative Selectively Inhibits the Reverse Mode of Na+/Ca2+ Exchange in Cells Expressing NCX1*

  1996cited by this paper
• Dominant role of mitochondria in clearance of large Ca2+ loads from rat adrenal chromaffin cells.

  1996cited by this paper
• Mitochondria, Calcium Regulation, and Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

  1996cited by this paper
• An obligate role for oxygen in the early stages of glutamate-induced, delayed neuronal death

  1995cited by this paper
• Kinetics of AP5 dissociation from NMDA receptors: evidence for two identical cooperative binding sites.

  1994cited by this paper
• Properties of neuroprotective cell-permeant Ca2+ chelators: effects on [Ca2+]i and glutamate neurotoxicity in vitro.

  1994cited by this paper
• Ion permeation properties of the cloned mouse ϵ2/ζ1 NMDA receptor channel

  1994cited by this paper
• Ion permeation properties of the cloned mouse epsilon 2/zeta 1 NMDA receptor channel.

  1994cited by this paper
• Glutamate impairs neuronal calcium extrusion while reducing sodium gradient.

  1994cited by this paper
• Cell-permeant Ca2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo.

  1993cited by this paper
• Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium

  1993cited by this paper
• Secondary Ca2+ overload indicates early neuronal injury which precedes staining with viability indicators.

  1993cited by this paper
• Intracellular calcium levels during the period of delayed excitotoxicity

  1993cited by this paper
• Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons

  1993cited by this paper
• Calcium-induced actin depolymerization reduces NMDA channel activity.

  1993cited by this paper
• Neuroprotective effects of glutamate antagonists and extracellular acidity.

  1993cited by this paper
• Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

  1992cited by this paper
• Excitotoxic cell death.

  1992cited by this paper
• Voltage‐gated and chemically gated ionic channels in the cultured cochlear ganglion neurone of the chick.

  1990cited by this paper
• Comparison of delayed administration of competitive and uncompetitive antagonists in preventing NMDA receptor‐mediated neuronal death

  1990cited by this paper
• Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro.

  1990cited by this paper
• Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death.

  1989cited by this paper
• Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

  1988cited by this paper
• Permeation and block of N‐methyl‐D‐aspartic acid receptor channels by divalent cations in mouse cultured central neurones.

  1987cited by this paper
• Identification of sodium‐calcium exchange current in single ventricular cells of guinea‐pig.

  1987cited by this paper
• A new generation of Ca2+ indicators with greatly improved fluorescence properties.

  1985cited by this paper
• Magnesium gates glutamate-activated channels in mouse central neurones

  1984cited by this paper
• Ethylisopropyl-amiloride: a new and highly potent derivative of amiloride for the inhibition of the Na+/H+ exchange system in various cell types.

  1983cited by this paper
• Ion transfer across lipid membranes in the presence of gramicidin A. II. The ion selectivity.

  1972cited by this paper
• Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

  1969cited by this paper

• NMDA‐Type Glutamate Receptor Activation Promotes Ischemic Arrhythmias by Targeting the AKT1–TBX3–Nav1.5 Axis

  2025cites this paper
• Calpain in Traumatic Brain Injury: From Cinderella to Central Player

  2025cites this paper
• A 3D Human Neuron-on-Chip Platform to Monitor Neuronal Injury Responses

  2025cites this paper
• Neuroprotective Effects of Noncanonical PAR1 Agonists on Cultured Neurons in Excitotoxicity

  2024cites this paper
• Regulatory Peptide Pro-Gly-Pro Accelerates Neuroregeneration of Primary Neuroglial Culture after Mechanical Injury in Scratch Test

  2024cites this paper
• Selective inhibitor of sodium-calcium exchanger, SEA0400, affects NMDA receptor currents and abolishes their calcium-dependent block by tricyclic antidepressants

  2024cites this paper
• Peptide and Peptidomimetic Inhibitors Targeting the Interaction of Collapsin Response Mediator Protein 2 with the N-Type Calcium Channel for Pain Relief.

  2024cites this paper
• LPS-Activated Microglial Cell-Derived Conditioned Medium Protects HT22 Neuronal Cells against Glutamate-Induced Ferroptosis

  2023cites this paper
• The Role of Retinal Ganglion Cell Structure and Function in Glaucoma

  2023cites this paper
• Research Progress on the Correlation between Blood Calcium and Hemorrhagic Progression and Neurological Prognosis in Traumatic Brain Injury

  2023cites this paper
• Honey on brain health: A promising brain booster

  2023cites this paper
• Cell specific regulation of NaV1.7 activity and trafficking in rat nodose ganglia neurons

  2022cites this paper
• Insulin Diminishes Superoxide Increase in Cytosol and Mitochondria of Cultured Cortical Neurons Treated with Toxic Glutamate

  2022cites this paper
• Neuroprotection against supra-lethal 'stroke in a dish' insults by an anti-excitotoxic receptor antagonist cocktail.

  2022cites this paper
• Retinal Glutamate Neurotransmission: From Physiology to Pathophysiological Mechanisms of Retinal Ganglion Cell Degeneration

  2022cites this paper
• Tricyclic Antidepressant Structure-Related Alterations in Calcium-Dependent Inhibition and Open-Channel Block of NMDA Receptors

  2022cites this paper
• Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats

  2022cites this paper
• Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15

  2021cites this paper
• Insulin Receptors and Intracellular Ca 2+ Form a Double-Negative Regulatory Feedback Loop Controlling Insulin Sensitivity

  2021cites this paper
• Insulin Normalizes Ionic Homeostasis and the State of Mitochondria after a Mechanical Damage to the Culture of Brain Neurons

  2021cites this paper
• IPSC-Derived Human Neurons with GCaMP6s Expression Allow In Vitro Study of Neurophysiological Responses to Neurochemicals

  2021cites this paper
• Insulin Normalizes Ionic Homeostasis and the State of Mitochondria after a Mechanical Damage to the Culture of Brain Neurons

  2021cites this paper
• Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15

  2021cites this paper
• Agmatine as a novel candidate for rapid-onset antidepressant response

  2021cites this paper
• Fluorescent Analysis Reveals that Insulin Diminishes Superoxide Increase in Neurons Induced with Toxic Glutamate Treatment

  2021cites this paper
• Brain Insulin Resistance: Focus on Insulin Receptor-Mitochondria Interactions

  2021cites this paper
• Insulin Receptors and Intracellular Ca 2+ Form a Double-Negative Regulatory Feedback Loop Controlling Insulin Sensitivity.

  2020cites this paper
• A Study of Gene Expression Changes in Human Spinal and Oculomotor Neurons; Identifying Potential Links to Sporadic ALS

  2020cites this paper
• Role of NAD+—Modulated Mitochondrial Free Radical Generation in Mechanisms of Acute Brain Injury

  2020cites this paper
• Impaired Glutamate Receptor Function Underlies Early Activity Loss of Ipsilesional Motor Cortex after Closed-Head Mild Traumatic Brain Injury

  2020cites this paper
• TARGETING Kv2.1/SYNTAXIN INTERACTION FOR NEUROPROTECTION

  2019cites this paper
• Insulin Protects Cortical Neurons Against Glutamate Excitotoxicity

  2019influential citation
• Effects of Tualang honey in modulating nociceptive responses at the spinal cord in offspring of prenatally stressed rats.

  2019cites this paper
• Therapeutic Effect of Agmatine on Neurological Disease: Focus on Ion Channels and Receptors

  2019cites this paper
• Inhibition of the Ubc9 E2 SUMO-conjugating enzyme–CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain

  2018cites this paper
• Analyzing the Behavior of Neuronal Pathways in Alzheimer's Disease Using Petri Net Modeling Approach

  2018influential citation
• Study of the Mechanism of the Neuron Sensitization to the Repeated Glutamate Challenge

  2018cites this paper
• Degradomics in Neurotrauma: Profiling Traumatic Brain Injury.

  2017cites this paper
• Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke

  2017cites this paper
• Calcium-mediated mechanisms of retinal ganglion cell degeneration during autoimmune optic neuritis

  2017cites this paper
• Función del intercambiador sodio calcio (NCX) en la hipoxia neuronal y la neuroprotección

  2016cites this paper
• Calcium regulation in mouse mesencephalic neurons-Differential roles of Na(+)/Ca(2+) exchanger, mitochondria and endoplasmic reticulum.

  2016cites this paper
• Protection of curcumin against amyloid-β-induced cell damage and death involves the prevention from NMDA receptor-mediated intracellular Ca2+ elevation

  2015cites this paper
• Prolonged glutamate excitotoxicity increases GluR1 immunoreactivity but decreases mRNA of GluR1 and associated regulatory proteins in dissociated rat retinae in vitro.

  2015cites this paper
• Mitochondrial Permeability Transition

  2015cites this paper
• The δ-Opioid Receptor and Stabilization of Brain Ionic Homeostasis in Hypoxia/Ischemia

  2015cites this paper
• Exploration of novel imaging agents and therapeutic targets for neurotrauma

  2014cites this paper
• Increased calcium influx triggers and accelerates cortical spreading depression in vivo in male adult rats.

  2014cites this paper
• Mechanisms, treatment and prevention of cellular injury and death from delayed events after aneurysmal subarachnoid hemorrhage

  2014cites this paper
• Study on ATP concentration changes in cytosol of individual cultured neurons during glutamate-induced deregulation of calcium homeostasis

  2014cites this paper
• Collapsin Response Mediator Protein 2 (CRMP2) Interacts with N-Methyl-d-aspartate (NMDA) Receptor and Na+/Ca2+ Exchanger and Regulates Their Functional Activity*

  2014influential citation
• In vitro mitochondrial failure and oxidative stress mimic biochemical features of Alzheimer disease.

  2013cites this paper
• Remote ischemic preconditioning as a means to protect the brain against hypothermic circulatory arrest : an experimental study on piglets

  2013cites this paper
• Altered Calcium Signaling Following Traumatic Brain Injury

  2012cites this paper
• Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons.

  2012influential citation
• Dual regulation of voltage- and ligand-gated calcium channels by collapsin response mediator protein 2

  2012cites this paper
• Effects of Tualang Honey on Pain Behaviour and Oxidative Stress in the Thalamus of Prenatally Stressed Rat Offspring

  year unknowncites this paper