Analysis and comparison of the effects of N-BiPAP and Bubble-CPAP in treatment of preterm newborns with the weight of below 1500 grams affiliated with respiratory distress syndrome: A randomised clinical trial

Background: Nowadays, establishment of nCPAP and surfactant administration is considered to be the first level of intervention for newborns engaged in the process of Respiratory Distress Syndrome (RDS). In order to decrease the side effects of the nCPAP management placed in noninvasive-non-cycled respiratory support. Noninvasive-cycled respiratory support mechanism have been developed such as N-BiPAP. Therefore, we compared N-BiPAP with Bubble-CPAP in a clinical trial. Materials and Methods: This research was done as an on newborns weighing less than 1500 grams affiliated with RDS. A3 The total number of newborns was 70. Newborns were divided into two groups with the sample size of 35 patients in each, according to odd and even document numbers. One group was treated with N-BiPAP and the other with Bubble-CPAP. Patients were compared according to the length of treatment with noninvasive respiratory support, length of oxygen intake, number of surfactant doses administered, need for invasive mechanical ventilation, apnea, patent ductus arteriosus (PDA), chronic lung disease, intraventricular hemorrhage, pneumothorax, and death. Data was recorded and compared. Results: The average duration for noninvasive respiratory support and the average time of need to complementary oxygen was not significantly different in both groups (P value > 0.05). Need for invasive ventilation, also chronic lung disease, intraventricular hemorrhage (IVH), pneumothorax, need for the next dose of surfactant, and the death rate did also have no meaningful difference. (P value > 0.05). Conclusion: In this research N-BiPAP did not show any obvious clinical preference over the Bubble-CPAP in treatment of newborns weighing less than 1500 grams and affiliated with RDS.

• Publication year

  2016

• Venue

  Advanced Biomedical Research

• Publication date

  2016-01-27

• Fields of study

  Medicine

• Identifiers
  DOI 10.4103/2277-9175.174965PMID 26955624PMCID 4763565
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nasal CPAP vs Bi-level Nasal CPAP in preterms with RDS: a randomized control study

  2017influential reference
• Prophylactic versus selective use of surfactant in preventing morbidity and mortality in preterm infants.

  2012cited by this paper
• Prophylactic versus Selective Use of Surfactant in Preventing Morbidity and Mortality in Preterm Infants

  2012cited by this paper
• Current methods of non-invasive ventilatory support for neonates.

  2011cited by this paper
• Clinical practice

  2010cited by this paper
• Very Early Surfactant Without Mandatory Ventilation in Premature Infants Treated With Early Continuous Positive Airway Pressure: A Randomized, Controlled Trial

  2009cited by this paper
• Synchronized Nasal Intermittent Positive-Pressure Ventilation and Neonatal Outcomes

  2009cited by this paper
• Non-invasive respiratory support of preterm neonates with respiratory distress: continuous positive airway pressure and nasal intermittent positive pressure ventilation.

  2009cited by this paper
• Early nasal intermittent positive pressure ventilation versus continuous positive airway pressure for respiratory distress syndrome

  2009cited by this paper
• Nasal continuous positive airway pressure (CPAP) versus bi-level nasal CPAP in preterm babies with respiratory distress syndrome: a randomised control trial

  2009cited by this paper
• Nasal CPAP or intubation at birth for very preterm infants.

  2008cited by this paper
• Early surfactant administration with brief ventilation vs selective surfactant and continued mechanical ventilation for preterm infants with or at risk for respiratory distress syndrome.

  2007cited by this paper
• Effects of non‐invasive pressure support ventilation (NI‐PSV) on ventilation and respiratory effort in very low birth weight infants

  2007cited by this paper
• Neonatal nasal intermittent positive pressure ventilation: a survey of practice in England

  2007cited by this paper
• Synchronized nasal intermittent positive pressure ventilation (SNIPPV) decreases work of breathing (WOB) in premature infants with respiratory distress syndrome (RDS) compared to nasal continuous positive airway pressure (NCPAP)

  2006cited by this paper
• Sustainable use of continuous positive airway pressure in extremely preterm infants during the first week after delivery

  2006cited by this paper
• Nasal Bilevel vs. Continuous Positive Airway Pressure in Preterm Infants

  2005influential reference
• Early extubation and nasal continuous positive airway pressure after surfactant treatment for respiratory distress syndrome among preterm infants <30 weeks' gestation.

  2004cited by this paper
• A randomised control study comparing the Infant Flow Driver with nasal continuous positive airway pressure in preterm infants

  2001cited by this paper
• Prophylactic versus selective use of surfactant in preventing morbidity and mortality in preterm infants.

  2001cited by this paper

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• Bubble NIPPV: Guidelines for Use

  2025cites this paper
• Non-invasive respiratory support in preterm infants as primary mode: a network meta-analysis.

  2025cites this paper
• Nasal CPAP and BiPAP as the Initial Respiratory Support in Preterm Infants: A Randomized Controlled Trial

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• Comparison of Effects between Nasal Bi-Level Positive Airway Pressure and Nasal Synchronized Intermittent Mandatory Ventilation in Neonatal Respiratory Distress Syndrome.

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• Application of Respiratory Support Technology in Neonatal Respiratory Distress Syndrome

  2023cites this paper
• Early nasal intermittent positive pressure ventilation (NIPPV) versus early nasal continuous positive airway pressure (NCPAP) for preterm infants.

  2023cites this paper
• Optimising bi-level non-invasive ventilation in preterm neonates: a systematic review

  2023cites this paper
• Nasal Intermittent Positive Pressure Ventilation for Neonatal Respiratory Distress Syndrome.

  2021cites this paper
• Noninvasive Ventilation

  2020cites this paper
• Non-invasive duo positive airway pressure ventilation versus nasal continuous positive airway pressure in preterm infants with respiratory distress syndrome: a randomized controlled trial

  2020influential citation
• Efficacy of noninvasive respiratory support modes for primary respiratory support in preterm neonates with respiratory distress syndrome: Systematic review and network meta‐analysis

  2020cites this paper
• Practical aspects on the use of non-invasive respiratory support in preterm infants

  2020cites this paper
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  2019cites this paper
• Nasal Intermittent Mandatory Ventilation Versus Nasal Continuous Positive Airway Pressure Before and After Invasive Ventilatory Support.

  2019cites this paper
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  2018cites this paper
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  2016cites this paper